Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Shu Z. Wiley"'
Autor:
Krishna Sriram, Shu Z. Wiley, Kevin Moyung, Matthew W. Gorr, Cristina Salmerón, Jordin Marucut, Randall P. French, Andrew M. Lowy, Paul A. Insel
Publikováno v:
ACS Omega, Vol 4, Iss 16, Pp 17048-17059 (2019)
Externí odkaz:
https://doaj.org/article/803525e5e05a4f8092a8f081d92b3d70
Autor:
Paul A. Insel, Krishna Sriram, Shu Z. Wiley, Andrea Wilderman, Trishna Katakia, Thalia McCann, Hiroshi Yokouchi, Lingzhi Zhang, Ross Corriden, Dongling Liu, Michael E. Feigin, Randall P. French, Andrew M. Lowy, Fiona Murray
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
G protein-coupled receptors (GPCRs), the largest family of targets for approved drugs, are rarely targeted for cancer treatment, except for certain endocrine and hormone-responsive tumors. Limited knowledge regarding GPCR expression in cancer cells l
Externí odkaz:
https://doaj.org/article/28de7d53db774f9b8b4d7ba1fda6c2d8
Autor:
Eric Greenwald, Clara Posner, Ananya Bharath, Anne Lyons, Cristina Salmerón, Krishna Sriram, Shu Z. Wiley, Paul A. Insel, Jin Zhang
Publikováno v:
ACS Sens
A major limitation of time-lapse microscopy combined with fluorescent biosensors, a powerful tool for quantifying spatiotemporal dynamics of signaling in single living cells, is low-experimental throughput. To overcome this limitation, we created a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d5ac9b73a62d6239c770849267635b
https://doi.org/10.1021/acssensors.2c01341
https://doi.org/10.1021/acssensors.2c01341
Publikováno v:
Future Med Chem
Cells in tumor microenvironments (TMEs) use several mechanisms to sense their low pH (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1367b61d33d1b5bf521c99c02d9798
https://doi.org/10.4155/fmc-2019-0357
https://doi.org/10.4155/fmc-2019-0357
Publikováno v:
Br J Pharmacol
Pancreatic cancer has one of the highest mortality rates (5-year survival ~9%) among cancers. Pancreatic adenocarcinoma (PAAD) is the most common (>80%) and the most lethal type of pancreatic cancer. A need exists for new approaches to treat pancreat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58bd0420076b6fc52f14253d68e357ea
https://europepmc.org/articles/PMC7205828/
https://europepmc.org/articles/PMC7205828/
Autor:
Kevin Moyung, Cristina Salmerón, Jordin Marucut, Krishna Sriram, Paul A. Insel, Andrew M. Lowy, Randall French, Shu Z. Wiley, Matthew W. Gorr
Publikováno v:
ACS Omega, Vol 4, Iss 16, Pp 17048-17059 (2019)
ACS Omega
ACS Omega
G protein-coupled receptors (GPCRs) are the largest family of membrane receptors and targets for approved drugs. Analysis of GPCR expression is thus important for drug discovery and typically involves mRNA-based methods. We compared transcriptomic cD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653968df4f67a23e4b4c5a89590aa6b5
Autor:
Shu Z. Wiley, Matthew W. Gorr, Paul A. Insel, Amy M. Chinn, Alexander V. Michkov, Krishna Sriram, Cristina Salmerón
Publikováno v:
Trends Pharmacol Sci
Trends in pharmacological sciences, vol 40, iss 6
Trends in pharmacological sciences, vol 40, iss 6
G protein-coupled receptors (GPCRs) are targets for ∼35% of approved drugs but only ∼15% of the ∼800 human GPCRs are currently such targets. GPCRomics, the use of unbiased, hypothesis-generating methods [e.g., RNA-sequencing (RNA-seq)], with ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ea9e4c5d7096bac67509e05c91c549
https://pubmed.ncbi.nlm.nih.gov/31078319
https://pubmed.ncbi.nlm.nih.gov/31078319
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8f310c1ee405201d8e574a569232dcc
https://doi.org/10.1096/fasebj.2018.32.1_supplement.695.4
https://doi.org/10.1096/fasebj.2018.32.1_supplement.695.4
Autor:
Shu Z. Wiley, Sarah Chang, Paul A. Insel, Wenjing Liang, Hiroshi Nishihara, Randall French, Thalia McCann, Andrew M. Lowy, Krishna Sriram
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2281d0c0ca35ac4b77f9b67ee466ad0
https://doi.org/10.1096/fasebj.2018.32.1_supplement.695.2
https://doi.org/10.1096/fasebj.2018.32.1_supplement.695.2
GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells
Autor:
Krishna Sriram, Paul A. Insel, Shu Z. Wiley, Jason K. Sicklick, Hiroshi Nishihara, Sarah E. Chang, Randall French, Wenjing Liang, Andrew M. Lowy, Thalia McCann
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(3)
The microenvironment of pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense fibrotic stroma (desmoplasia) generated by pancreatic cancer-associated fibroblasts (CAFs) derived from pancreatic stellate cells (PSCs) and pancreatic fibrob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952f1f482421d8a258302199b44d16ee
https://pubmed.ncbi.nlm.nih.gov/29092903
https://pubmed.ncbi.nlm.nih.gov/29092903