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Akademický článek

Discovery of novel BTK PROTACs with improved metabolic stability via linker rigidification strategy

Autor: Chen, Song, Chen, Zhendong, Lu, Lixue, Zhao, Yunpeng, Zhou, Ronghui, Xie, Qiong, Shu, Yongzhi, Lin, Jun, Yu, Xufen, Wang, Yonghui

Publikováno v: In European Journal of Medicinal Chemistry 5 July 2023 255

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Akademický článek

Discovery of novel BTK PROTACs for B-Cell lymphomas

Autor: Zhao, Yunpeng, Shu, Yongzhi, Lin, Jun, Chen, Zhendong, Xie, Qiong, Bao, Yanning, Lu, Lixue, Sun, Nannan, Wang, Yonghui

Publikováno v: In European Journal of Medicinal Chemistry 5 December 2021 225

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Targeted selective degradation of Bruton’s tyrosine kinase by PROTACs

Autor: Renjie Yan, Shaodong Liu, Feng Wang, Pei Lin, Shu Yongzhi, Jun Lin, Yang Da

Publikováno v: Medicinal Chemistry Research. 29:802-808

Bruton’s tyrosine kinase (BTK) is critical for B-cell receptor signaling and related to many types of human cancers. However, the drug resistance and off-target effect of present traditional BTK inhibitors occurred over time. As a new strategy for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dade509ed9f01ec75ccb113d3e52bbb6
https://doi.org/10.1007/s00044-020-02526-3

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Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects

Autor: Jun Lin, Shu Yongzhi, Shaodong Liu, Pei Lin, Renjie Yan, Feng Wang, Yang Da

Publikováno v: Medicinal Chemistry Research. 29:334-340

Androgen receptor (AR) reactivation was closely related with the recurrence of human prostate cancer. Currently, several limitations of AR inhibitors impede their application, such as the acquired drug resistance and the potential off-target binding.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77f84c8b7a4e91021e3b92a206343c65
https://doi.org/10.1007/s00044-019-02485-4

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Synthesis and Antitumor Activity of (3-Hydroxyacrylato-O,O′) Diammineplatinum(II)

Autor: Lin Jun, Zhou Bin, Shu Yongzhi, Liu Quanhai, Zhu Baoquan, Hu Haifeng, Dian-Wen Ju

Publikováno v: Pharmaceutical Fronts, Vol 03, Iss 01, Pp e13-e17 (2021)

As an indispensable part of cancer chemotherapy, platinum drugs still play an important role in cancer treatment. In this study, two platinum(II) complexes with Michael acceptor 3-hydroxyacrylic acid as the leaving group were synthesized from cis-dia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8409a439d506231ff9e6cd5976e7ed6f
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1730956

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Akademický článek

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