Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Shu Qiang Sun"'
1
Fibroblast-specific expression of AC6 enhances β-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis
Autor: Shu Qiang Sun, Fengying Li, Louisa Balazs, Muthusamy Thangavel, Joseph Kaminsky, Rennolds S. Ostrom, Xiaoqiu Liu
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 298:L819-L829
Pulmonary fibroblasts regulate extracellular matrix production and degradation and are critical in maintenance of lung structure, function, and repair, but they also play a central role in lung fibrosis. cAMP-elevating agents inhibit cytokine- and gr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd72145701c0b2af23d4d5a3f00d729
https://doi.org/10.1152/ajplung.00429.2009
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2
The C1 and C2 domains target human type 6 adenylyl cyclase to lipid rafts and caveolae
Autor: Shu Qiang Sun, Xiaoqiu Liu, Joseph Kaminsky, Rennolds S. Ostrom, Muthusamy Thangavel
Publikováno v: Cellular Signalling. 21:301-308
Previous data has shown that adenylyl cyclase type 6 (AC6) is expressed principally in lipid rafts or caveolae of cardiac myocytes and other cell types while certain other isoforms of AC are excluded from these microdomains. The mechanism by which AC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6e9b710f43085be68f84d9d15d7051
https://doi.org/10.1016/j.cellsig.2008.10.017
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3
cAMP Inhibits Transforming Growth Factor-β-Stimulated Collagen Synthesis via Inhibition of Extracellular Signal-Regulated Kinase 1/2 and Smad Signaling in Cardiac Fibroblasts
Autor: Aviv I. Hassid, Shu Qiang Sun, Xiaoqiu Liu, Rennolds S. Ostrom
Publikováno v: Molecular Pharmacology. 70:1992-2003
Cardiac fibroblasts produce and degrade extracellular matrix and are critical in regulating cardiac remodeling and hypertrophy. Cytokines such as transforming growth factor-beta (TGF-beta) play a fundamental role in the development of tissue fibrosis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7762bdd3dd0af2857ad972ebea7503ae
https://doi.org/10.1124/mol.106.028951
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4
Adenylyl Cyclase Type VI Gene Transfer Reduces Phospholamban Expression in Cardiac Myocytes via Activating Transcription Factor 3
Autor: Tong Tang, James R. Feramisco, H. Kirk Hammond, Tracy Guo, Mei Hua Gao, Shu Qiang Sun
Publikováno v: Journal of Biological Chemistry. 279:38797-38802
Cardiac-directed expression of adenylyl cyclase type VI (AC(VI)) increases stimulated cAMP production, improves heart function, and increases survival in cardiomyopathy. In contrast, pharmacological agents that increase intracellular levels of cAMP h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252543038da6ab721b0e581fa252e3ea
https://doi.org/10.1074/jbc.m405701200
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5
Adenylyl cyclase type 6 overexpression selectively enhances beta-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts
Autor: Penden Mahautmr, Rennolds S. Ostrom, Shu Qiang Sun, John Hwa, Muthusamy Thangavel, Xiaoqiu Liu, Joseph Kaminsky, Jeremiah Stitham
Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology. 377(4-6)
Cardiac fibroblasts produce and degrade extracellular matrix and are critical in regulating cardiac remodeling and hypertrophy. Fibroblasts are activated by factors such as transforming growth factor beta and inhibited by agents that elevate 3',5'-cy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75631275a4b8e63b832c1827cd14e91
https://pubmed.ncbi.nlm.nih.gov/17934720
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6
TGFß Signaling via ERK1/2 and Smad is Inhibited by cAMP‐Elevating Agents in Rat Cardiac Fibroblasts
Autor: Xiaoqiu Liu, Rennolds S. Ostrom, Shu Qiang Sun
Publikováno v: The FASEB Journal. 20
Cardiac fibroblasts (CF) play a central role in the maintenance of extracellular matrix in the normal heart and in inflammatory and fibrotic myocardial remodeling in the injured or failing heart. C...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93214fe80978d69ea6440bcb06e3d78e
https://doi.org/10.1096/fasebj.20.5.a1465
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9
Fibrotic lung fibroblasts show blunted inhibition by cAMP due to deficient cAMP response element-binding protein phosphorylation
Autor: Xiaoqiu Liu, Shu Qiang Sun, Rennolds S. Ostrom
Publikováno v: The Journal of pharmacology and experimental therapeutics. 315(2)
Pulmonary fibroblasts regulate extracellular matrix production and degradation; thus, they are critical for maintenance of lung structure, function, and repair. In pulmonary fibrosis, fibroblasts produce excess collagen and form fibrotic foci that ev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43bc1ccd330b9812fa3deca63ae48bb
https://pubmed.ncbi.nlm.nih.gov/16079300
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10
Akademický článek
Fibroblast-specific expression of AC6 enhances β-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis.
Autor: Xiaoqiu Liu, Fengying Li, Shu Qiang Sun, Thangavel, Muthusamy, Kaminsky, Joseph, Balazs, Louisa, Ostrom, Rennolds S.
Publikováno v: American Journal of Physiology: Lung Cellular & Molecular Physiology; Jun2010, Vol. 298, pL819-L829, 11p, 1 Color Photograph, 3 Black and White Photographs, 2 Charts, 5 Graphs
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