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Hydrolytic and Metabolic Characteristics of the Esters of1-(3′-Hydroxypropyl)-2-methyl-3-hydroxypyridin-4-one (CP41), Potentially Useful Iron Chelators

Autor: Ding Y. Liu, Zu D. Liu, Robert C. Hider, Shu L. Lu

Publikováno v: Pharmacology & Toxicology. 86:228-233

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64454fb58e8dadf4720181a122e2de62
https://doi.org/10.1034/j.1600-0773.2000.pto860506.x

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Hydrolytic and Metabolic Characteristics of the Esters of1-(3'-Hydroxypropyl)-2-methyl-3-hydroxypyridin-4-one (CP41), Potentially Useful Iron Chelators

Autor: Robert C. Hider, Shu L. Lu, Ding Y. Liu, Zu D. Liu

Publikováno v: Pharmacology and Toxicology. 86:228-233

1-(3'-Hydroxypropyl)-2-methyl-3-hydroxypyridin-4-one (CP41) has been extensively investigated as an orally effective iron chelator. In order to improve the pharmacokinetic and metabolic properties of CP41, eleven aromatic esters have been synthesised

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d7c9d0ca8f74aac6ad1645c7aa32ec
https://doi.org/10.1034/j.1600-0773.2000.d01-40.x

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Synthesis, Physicochemical Characterization, and Biological Evaluation of 2-(1‘-Hydroxyalkyl)-3-hydroxypyridin-4-ones: Novel Iron Chelators with Enhanced pFe3+ Values

Autor: Ding Y. Liu, Shu L. Lu, Zu D. Liu, Robert C. Hider, Hicham Khodr

Publikováno v: Journal of Medicinal Chemistry. 42:4814-4823

The synthesis of a range of 2-(1'-hydroxyalkyl)-3-hydroxypyridin-4-ones as bidentate iron(III) chelators with potential for oral administration is described. The pK(a) values of the ligands and the stability constants of their iron(III) complexes hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b21b0de95595bb52be2141775850cd
https://doi.org/10.1021/jm991080o

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Gradient ion-pair high-performance liquid chromatographic method for analysis of 3-hydroxypyridin-4-one iron chelators

Autor: Ding Y. Liu, Shu L. Lu, Robert C. Hider, Zu D. Liu

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 730:135-139

A gradient ion-pair HPLC separation of highly hydrophilic 3-hydroxypyridin-4-one (HPO) iron chelators is described. The ˚ separation of HPOs was performed using a reversed-phase polymer HPLC column (PLRP-S 100 A, 1530.46 cm ID, 5 mm). The ion-pair b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c262e5f23209d77a9ce86a3f7a2965dd
https://doi.org/10.1016/s0378-4347(99)00198-x

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Design, synthesis and evaluation of N-basic substituted 3-hydroxypyridin-4-ones: orally active iron chelators with lysosomotrophic potential

Autor: Shu L. Lu, Robert C. Hider, Zu D. Liu, Hicham Khodr

Publikováno v: The Journal of pharmacy and pharmacology. 52(3)

To investigate the possibility of targeting chelators into the lysosomal iron pool, nine bidentate 3-hydroxypyridin-4-ones with basic chains have been synthesized. As the turnover of ferritin iron is centred in the lysosome, such strategy is predicte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6a21bc3054d3ad2e38088ee5b14529
https://pubmed.ncbi.nlm.nih.gov/10757413

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Liquid extraction and ion-pair HPLC for determination of hydrophilic 3-hydroxypyridin-4-one iron chelators

Autor: Zu D. Liu, Shu L. Lu, Ding Y. Liu, Robert C. Hider

Publikováno v: Journal of pharmaceutical and biomedical analysis. 21(4)

Hydrophilic 3-hydroxypyridin-4-ones (HPOs), such as 1-(2'-carboxyethyl)-2-methyl-3-hydroxypyridin-4-one (CP38), 1-(3'-hydroxypropyl)-2-methyl-3-hydroxypyridin-4-one (CP41) and 1-(2'-hydroxyethyl)-2-ethyl-3-hydroxypyridin-4-one (CP102), are orally act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e219d4eb018dcdc706ef4f826ed510
https://pubmed.ncbi.nlm.nih.gov/10701941

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