Metabolic remodeling in tumor-associated macrophages contributing to antitumor activity of cryptotanshinone by regulating TRAF6-ASK1 axis

Autor: Jia-Hau Yen, Wei-Chieh Huang, Shu-Ching Lin, Yi-Wen Huang, Wan-Ting Chio, Gregory J. Tsay, Mien-Chie Hung, Sheng-Teng Huang

Publikováno v: Molecular Therapy: Oncolytics, Vol 26, Iss , Pp 158-174 (2022)

Dampening tumor growth by converting tumor-associated macrophages (TAMs) from M2/repair-types to M1/kill-types is of high interest. Here, we show that cryptotanshinone (CPT) can function as an antitumor immune modulator that switches TAMs from an M2

Externí odkaz: https://doaj.org/article/eeb1f4dfbe7f4ee19fb174667b0e7c69

Autophagy Upregulates miR-449a Expression to Suppress Progression of Colorectal Cancer

Autor: Sheng-Hui Lan, Shu-Ching Lin, Wei-Chen Wang, Yu-Chan Yang, Jenq-Chang Lee, Pei-Wen Lin, Man-Ling Chu, Kai-Ying Lan, Roberto Zuchini, Hsiao-Sheng Liu, Shan-Ying Wu

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Many studies reported that microRNAs (miRNAs) target autophagy-related genes to affect carcinogenesis, however, autophagy-deficiency-related miRNA dysfunction in cancer development remains poorly explored. During autophagic progression, we identified

Externí odkaz: https://doaj.org/article/d2597a9e82fa4b389240004411da9254

Higher NAFLD fibrosis score is associated with impaired eGFR

Autor: Meng-Hsuan Hsieh, Kuan-Ta Wu, Yi-Yu Chen, Jeng-Fu Yang, Wen-Yi Lin, Ning-Chia Chang, Chia-Yi Lin, Chao-Kuan Huang, Chao-Ling Wang, Hung-Yi Chuang, Shu-Ching Lin, Yu-Kuei Hsu, Yi-Shan Tsai, Wan-Long Chuang, Ming-Lung Yu, Chia-Yen Dai

Publikováno v: Journal of the Formosan Medical Association, Vol 119, Iss 1, Pp 496-503 (2020)

Background/Purpose: Chronic kidney disease (CKD) has become a worldwide health problem, leading to high morbidity and mortality, and non-alcoholic fatty liver disease (NAFLD) is considered a risk factor for CKD. The aim of this study was to explore t

Externí odkaz: https://doaj.org/article/2ff17514de6f4cd68a2026c3095ef519

Dual-acting antibacterial porous chitosan film embedded with a photosensitizer

Autor: Shu-Ching Lin, Pei-Yuan Lee, Gou-Jen Wang, Zi-Lun Lai, Zi-Jun Liu, Cheng-Chung Chang, Ying-Ting Lin

Publikováno v: Science and Technology of Advanced Materials, Vol 21, Iss 1, Pp 562-572 (2020)
Science and Technology of Advanced Materials
article-version (VoR) Version of Record

This study proposes to develop a dual-acting antibacterial film of porous chitosan (Cs) embedded with small molecular compound, which possesses photosensitive characteristics with bactericidal efficacy, to promote the accelerated recovery of infectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca2ef77af7c3d77cdd013fdcd17d772
https://doaj.org/article/a332d9b0ff5f4beb94fedc9acdcf43a5

Investigation of antibacterial property of novel small molecular and its applications on wound dressings

Autor: Shu-Ching Lin, 林淑卿

106
The main purpose of this study is to investigate the antibacterial activity of four synthesized photosensitivity small molecule compounds, which we used to produce antibacterial chitosan porous wound dressings to accelerate wound healing pro

Externí odkaz: http://ndltd.ncl.edu.tw/handle/7a86e4