Výsledky vyhledávání - "Shu Chin Yip"

Data from Activation of Src by Protein Tyrosine Phosphatase 1B Is Required for ErbB2 Transformation of Human Breast Epithelial Cells

Autor: Jonathan Chernoff, Zhong-Yin Zhang, Stephen P. Ethier, Shu-Chin Yip, Olga Villamar-Cruz, Sayanti Saha, Luis E. Arias-Romero

Protein tyrosine phosphatase (PTP) 1B plays a major role in inhibiting signaling from the insulin and leptin receptors. Recently, PTP1B was found to have an unexpected positive role in ErbB2 signaling in a mouse model of breast cancer, but the mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eff3cf13d232493fdb91e4393dd49d0b
https://doi.org/10.1158/0008-5472.c.6499185.v1

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Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1

Autor: Hua Ding, Veda N. Giri, Timothy J. Yen, Alfonso Bellacosa, Robert W. Sobol, Maria Rosaria Bassi, Pietro Mancuso, Luigi Bagella, Emmanuelle Nicolas, Valentina Doneddu, Jonathan Chernoff, Steven H. Seeholzer, Salvatore Cortellino, Shu-Chin Yip, Mara Sannai, Antonio Cigliano, Rebecca Lurie

Publikováno v: DNA Repair (Amst)

The base excision repair DNA N-glycosylase MBD4 (also known as MED1), an interactor of the DNA mismatch repair protein MLH1, plays a central role in the maintenance of genomic stability of CpG sites by removing thymine and uracil from G:T and G:U mis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ca9a0cb8700541e27e4c3f35d8c8d3
https://doi.org/10.1016/j.dnarep.2019.102687

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RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells

Autor: Huan Pang, Mike Lorenz, Klaus M. Hahn, Jonathan M. Backer, John S. Condeelis, Mirvat El-Sibai, Shu Chin Yip, Olivier Pertz, Marc Symons

Publikováno v: Experimental Cell Research. 314:1540-1552

Rho GTPases are versatile regulators of cell shape that act on the actin cytoskeleton. Studies using Rho GTPase mutants have shown that, in some cells, Rac1 and Cdc42 regulate the formation of lamellipodia and filopodia, respectively at the leading e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fd159dc348535732826fb4e368f1d2
https://doi.org/10.1016/j.yexcr.2008.01.016

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The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration

Autor: John S. Condeelis, Robert J. Eddy, Salvatore J. Coniglio, Marc Symons, Shu Chin Yip, Beth E. Drees, Paul O. Neilsen, Sumanta Goswami, Mirvat El-Sibai, Jonathan M. Backer, Ghassan Mouneimne

Publikováno v: Journal of Cell Science. 120:3138-3146

Cell migration involves the localized extension of actin-rich protrusions, a process that requires Class I phosphoinositide 3-kinases (PI 3-kinases). Both Rac and Ras have been shown to regulate actin polymerization and activate PI 3-kinase. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6385ee17a8d57b574cace404ed85008b
https://doi.org/10.1242/jcs.005298

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Over-expression of the p110? but not p110? isoform of PI 3-kinase inhibits motility in breast cancer cells

Autor: Jonathan M. Backer, John S. Condeelis, Karen M. Hill, Haiyan Wu, Shu Chin Yip, Mirvat El-Sibai, Zheng Fu

Publikováno v: Cell Motility and the Cytoskeleton. 59:180-188

Phosphoinositide 3-kinase (PI 3-kinase) activity is required for growth factor-induced cytoskeletal regulation and cell migration. We previously found that in MTLn3 rat adenocarcinoma cells, EGF-stimulated induction of actin barbed ends and lamellipo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664172b742292e618a2415c97af98c77
https://doi.org/10.1002/cm.20032

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Local signaling by the EGF receptor

Autor: Stephan J. Kempiak, Shu Chin Yip, Jeffrey E. Segall, Jonathan M. Backer

Publikováno v: The Journal of Cell Biology

Differing spatial scales of signaling cascades are critical for cell orientation during chemotactic responses. We used biotin EGF bound to streptavidin-coupled magnetic beads to locally stimulate cells overexpressing the EGF receptor. We have found t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3abf6a4d2ce53dadf9716735429ebe6
https://doi.org/10.1083/jcb.200303144

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N-terminal Domains of the Class IA Phosphoinositide 3-Kinase Regulatory Subunit Play a Role in Cytoskeletal but Not Mitogenic Signaling

Autor: Karen M. Hill, Jeffrey E. Segall, Jinghua Yu, Shu Chin Yip, Yuhong Huang, Jonathan M. Backer

Publikováno v: Journal of Biological Chemistry. 276:16374-16378

Phosphoinositide (PI) 3-kinases are required for the acute regulation of the cytoskeleton by growth factors. We have shown previously that in the MTLn3 rat adenocarcinoma cells line, the p85/p110alpha PI 3-kinase is required for epidermal growth fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0b658cf129afeb3eba290aa30370be
https://doi.org/10.1074/jbc.m006985200

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Specific Requirement for the p85-p110α Phosphatidylinositol 3-Kinase during Epidermal Growth Factor-stimulated Actin Nucleation in Breast Cancer Cells

Autor: Karen M. Hill, James Murray, Jonathan M. Backer, Jeffrey E. Segall, Susan Welti, Jinghua Yu, John S. Condeelis, Shu Chin Yip

Publikováno v: Journal of Biological Chemistry. 275:3741-3744

We have studied the role of phosphatidylinositol 3-kinases (PI 3-kinases) in the regulation of the actin cytoskeleton in MTLn3 rat adenocarcinoma cells. Stimulation of MTLn3 cells with epidermal growth factor (EGF) induced a rapid increase in actin p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac6e54ad79b622ca7a1515c15b3907e
https://doi.org/10.1074/jbc.275.6.3741

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