Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Shu‐Leong Ho"'
Autor:
Eunice Eun-Seo Chang, Huifang Liu, Zoe Yuen-Kiu Choi, Yasine Malki, Steffi Xi-Yue Zhang, Shirley Yin-Yu Pang, Michelle Hiu-Wai Kung, David B. Ramsden, Shu-Leong Ho, Philip Wing-Lok Ho
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Stress-induced activation of ERK/Drp1 serves as a checkpoint in the segregation of damaged mitochondria for autophagic clearance (mitophagy). Elevated cytosolic calcium (Ca2+) activates ERK, which is pivotal to mitophagy initiatio
Externí odkaz:
https://doaj.org/article/982bf080882144a892ab9cf7094a418c
Autor:
Philip Wing-Lok Ho, Eunice Eun-Seo Chang, Chi-Ting Leung, Huifang Liu, Yasine Malki, Shirley Yin-Yu Pang, Zoe Yuen-Kiu Choi, Yingmin Liang, Weng Seng Lai, Yuefei Ruan, Kenneth Mei-Yee Leung, Susan Yung, Judith Choi-Wo Mak, Michelle Hiu-Wai Kung, David B. Ramsden, Shu-Leong Ho
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-22 (2022)
Abstract Parkinson’s disease (PD) is characterized by dopaminergic neurodegeneration in nigrostriatal and cortical brain regions associated with pathogenic α-synuclein (αSyn) aggregate/oligomer accumulation. LRRK2 hyperactivity is a disease-modif
Externí odkaz:
https://doaj.org/article/2e279dd54a294707af03424d9d6a60c0
Autor:
Eunice Eun Seo Chang, Philip Wing-Lok Ho, Hui-Fang Liu, Shirley Yin-Yu Pang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, David Boyer Ramsden, Shu-Leong Ho
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-19 (2022)
Abstract Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are one of the most frequent genetic causes of both familial and sporadic Parkinson’s disease (PD). Mounting evidence has demonstrated pathological similarities between LRRK2-assoc
Externí odkaz:
https://doaj.org/article/06ce894a7bfb40c5b4c49bef2bb50a60
Autor:
Shirley Yin-Yu Pang, Rachel Cheuk Nam Lo, Philip Wing-Lok Ho, Hui-Fang Liu, Eunice Eun Seo Chang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, Wing Yan Wong, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong Ho
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-14 (2022)
Abstract Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are a
Externí odkaz:
https://doaj.org/article/b6fc3201296c4ede996e68a53646446e
Autor:
Philip Wing‐Lok Ho, Lingfei Li, Hui‐Fang Liu, Zoe Yuen‐Kiu Choi, Eunice Eun Seo Chang, Shirley Yin‐Yu Pang, Yasine Malki, Chi‐Ting Leung, Michelle Hiu‐Wai Kung, David Boyer Ramsden, Shu‐Leong Ho
Publikováno v:
Brain and Behavior, Vol 13, Iss 2, Pp n/a-n/a (2023)
Abstract Background Leucine‐rich repeat kinase 2 (LRRK2) mutation is a common genetic risk factor of Parkinson's disease (PD). Presynaptic dysfunction is an early pathogenic event associated with dopamine (DA) dysregulation in striatum of the brain
Externí odkaz:
https://doaj.org/article/2ee981caa3584b2cabee05ffa1a8e5db
Autor:
Juan Pablo Castello, Kay‐Cheong Teo, Jessica R. Abramson, Sophia Keins, Courtney E. Takahashi, Ian Y. H. Leung, William C. Y. Leung, Yujie Wang, Christina Kourkoulis, Evangelos Pavlos Myserlis, Andrew D. Warren, Jonathan Henry, Koon‐Ho Chan, Raymond T. F. Cheung, Shu‐Leong Ho, M. Edip Gurol, Anand Viswanathan, Steven M. Greenberg, Christopher D. Anderson, Kui‐Kai Lau, Jonathan Rosand, Alessandro Biffi
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 6 (2022)
Background Survivors of intracranial hemorrhage (ICH) are at increased risk for major adverse cardiovascular and cerebrovascular events (MACCE), in the form of recurrent stroke and myocardial Infarction. We investigated whether long‐term blood pres
Externí odkaz:
https://doaj.org/article/99a20019d4af4faa887d60e310a05936
Autor:
Alessandro Biffi, Kay‐Cheong Teo, Juan Pablo Castello, Jessica R. Abramson, Ian Y. H. Leung, William C. Y. Leung, Yujie Wang, Christina Kourkoulis, Evangelos Pavlos Myserlis, Andrew D. Warren, Jonathan Henry, Koon‐Ho Chan, Raymond T. F. Cheung, Shu‐Leong Ho, Christopher D. Anderson, M. Edip Gurol, Anand Viswanathan, Steven M. Greenberg, Kui‐Kai Lau, Jonathan Rosand
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 11 (2021)
Background Survivors of intracerebral hemorrhage (ICH) are at high risk for recurrent stroke, which is associated with blood pressure control. Because most recurrent stroke events occur within 12 to 18 months of the index ICH, rapid blood pressure co
Externí odkaz:
https://doaj.org/article/e908d8ed84ee4ce1ae40653e46e63e14
Autor:
Shirley Yin-Yu Pang, Philip Wing-Lok Ho, Hui-Fang Liu, Chi-Ting Leung, Lingfei Li, Eunice Eun Seo Chang, David Boyer Ramsden, Shu-Leong Ho
Publikováno v:
Translational Neurodegeneration, Vol 8, Iss 1, Pp 1-11 (2019)
Abstract Background Parkinson’s disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB). During the course of disease, misfolded α-synuclein, the major
Externí odkaz:
https://doaj.org/article/43d50c8ae87c483988f526d2505c7897
Autor:
Shirley Yin-Yu Pang, Kay-Cheong Teo, Jacob Shujui Hsu, Richard Shek-Kwan Chang, Miaoxin Li, Pak-Chung Sham, Shu-Leong Ho
Publikováno v:
Translational Neurodegeneration, Vol 6, Iss 1, Pp 1-11 (2017)
Abstract The clinical diagnosis of neurodegenerative disorders based on phenotype is difficult in heterogeneous conditions with overlapping symptoms. It does not take into account the disease etiology or the highly variable clinical course even among
Externí odkaz:
https://doaj.org/article/b3d43f28d09044c598ac8af8ada40da3
Autor:
Kui-Kai Lau, Yuen-Kwun Wong, Kay-Cheong Teo, Richard Shek-Kwan Chang, Sonny Fong-Kwong Hon, Koon-Ho Chan, Raymond Tak-Fai Cheung, Leonard Sheung-Wai Li, Hung-Fat Tse, Shu-Leong Ho, Chung-Wah Siu
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88283 (2014)
BACKGROUND AND PURPOSE: Cancer patients are at increased risk of cardiovascular and cerebrovascular events. It is unclear whether cancer confers any additional risk for recurrent stroke or cardiovascular mortality after stroke. METHODS: This was a si
Externí odkaz:
https://doaj.org/article/a16ad2d8e70e4ccca9da9c5c5dbb2594