Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Shu‐Heng Jiang"'
Autor:
Jia-Hao Zheng, Yu-Heng Zhu, Jian Yang, Pei-Xuan Ji, Rui-Kang Zhao, Zong-Hao Duan, Hong-Fei Yao, Qin-Yuan Jia, Yi-Fan Yin, Li-Peng Hu, Qing Li, Shu-Heng Jiang, Yan-Miao Huo, Wei Liu, Yong-Wei Sun, De-Jun Liu
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114633- (2024)
Summary: Pancreatic ductal adenocarcinoma (PDAC) features substantial matrix stiffening and reprogrammed glucose metabolism, particularly the Warburg effect. However, the complex interplay between these traits and their impact on tumor advancement re
Externí odkaz:
https://doaj.org/article/3e191bdb041148d8ad4a43c8690cab09
Autor:
Qing Li, Xiao-Xin Zhang, Li-Peng Hu, Bo Ni, Dong-Xue Li, Xu Wang, Shu-Heng Jiang, Hui Li, Min-Wei Yang, Yong-Sheng Jiang, Chun-Jie Xu, Xue-Li Zhang, Yan-Li Zhang, Pei-Qi Huang, Qin Yang, Yang Zhou, Jian-ren Gu, Gary Gui-Shan Xiao, Yong-wei Sun, Jun Li, Zhi-Gang Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Pancreatic ductal adenocarcinoma (PDAC) cells can utilise the tumour microenvironment to metastasise to the liver. Here the authors show that hepatoctyes overexpress SLIT2 to enable premetastatic niche formation for ROBO1-positive PDAC cells to suppo
Externí odkaz:
https://doaj.org/article/c0db6eed419d4fa68ab125432f399435
Autor:
Rongkun Li, Hengchao Li, Lili Zhu, Xiaoxin Zhang, Dejun Liu, Qing Li, Bo Ni, Lipeng Hu, Zhigang Zhang, Yanli Zhang, Xu Wang, Shu-Heng Jiang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-14 (2021)
Abstract Hypoxic microenvironment is common in solid tumors, particularly in pancreatic ductal adenocarcinoma (PDAC). The Warburg effect is known to facilitate cancer aggressiveness and has long been linked to hypoxia, yet the underlying mechanism re
Externí odkaz:
https://doaj.org/article/a9866d1660f44f8aa236aeb1f6f49da1
Autor:
Jian‐Yu Yang, Yan‐Miao Huo, Min‐Wei Yang, Yang Shen, De‐Jun Liu, Xue‐Liang Fu, Ling‐Ye Tao, Rui‐Zhe He, Jun‐Feng Zhang, Rong Hua, Shu‐Heng Jiang, Yong‐Wei Sun, Wei Liu
Publikováno v:
Molecular Oncology, Vol 15, Iss 11, Pp 3076-3090 (2021)
Hot spot gene mutations in splicing factor 3b subunit 1 (SF3B1) are observed in many types of cancer and create abundant aberrant mRNA splicing, which is profoundly implicated in tumorigenesis. Here, we identified that the SF3B1 K700E (SF3B1K700E) mu
Externí odkaz:
https://doaj.org/article/a9c8f091e2da47fb82b13e91b61dc03a
Autor:
Fangyuan Dong, Rongkun Li, Jiaofeng Wang, Yan Zhang, Jianfeng Yao, Shu-Heng Jiang, Xiaona Hu, Mingxuan Feng, Zhijun Bao
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-15 (2021)
Abstract Background Reprogrammed glucose metabolism, also known as the Warburg effect, which is essential for tumor progression, is regarded as a hallmark of cancer. MAP17, a small 17-kDa non-glycosylated membrane protein, is frequently dysregulated
Externí odkaz:
https://doaj.org/article/48224156d91544cea1212f69a50fb5d7
Autor:
Li-Peng Hu, Kai-Xia Zhou, Yan-Miao Huo, De-Jun Liu, Qing Li, Min-Wei Yang, Pei-Qi Huang, Chun-Jie Xu, Guang-Ang Tian, Lin-Li Yao, Xue-Li Zhang, Ya-Hui Wang, Jun Li, Zhi-Gang Zhang, Shu-Heng Jiang, Xin Xing, Xu Wang, Wei-Ting Qin, Qin Yang
Publikováno v:
Oncogenesis, Vol 10, Iss 3, Pp 1-11 (2021)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, which lacks effective treatment strategies. There is an urgent need for the development of new strategies for PDAC therapy. The genetic and phenotypic heterogeneity of
Externí odkaz:
https://doaj.org/article/b390422c94f543ee8980cc467d58e1b0
Autor:
Zi-Yang Zheng, Tao Jiang, Zhen-Fei Huang, Bo Chu, Jun Gu, Xuan Zhao, Hao Liu, Jin Fan, Li-Peng Yu, Shu-Heng Jiang, Qing Li, Li-Peng Hu, Fan-Qi Kong, Lai Zhang, Qi Chen, Jian Chen, Han-Wen Zhang, Guo-Yong Yin, Shu-Jie Zhao
Publikováno v:
Redox Biology, Vol 53, Iss , Pp 102326- (2022)
The nonunion following a fracture is associated with severe patient morbidity and economic consequences. Currently, accumulating studies are focusing on the importance of macrophages during fracture repair. However, details regarding the process by w
Externí odkaz:
https://doaj.org/article/4b8cb90510184e8d9811eb84572c8588
Autor:
Shu-Heng Jiang, Dejun Liu, Li-Peng Hu, Shan Zhang, Yanqiu Yu, Yong-Wei Sun, Jianguang Ji, Zhi-Gang Zhang
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104050- (2022)
Summary: Background: Cancer elicits a complex adaptive response in an organism. Limited information is available for the body-wide effects induced by cancer. Here, we evaluated multiorgan changes in mouse models of pancreatic ductal adenocarcinoma (P
Externí odkaz:
https://doaj.org/article/78a28158243e4b64bca89e839dd3acf5
Autor:
Xu Wang, Li-Peng Hu, Wei-Ting Qin, Qin Yang, De-Yu Chen, Qing Li, Kai-Xia Zhou, Pei-Qi Huang, Chun-Jie Xu, Jun Li, Lin-Li Yao, Ya-Hui Wang, Guang-Ang Tian, Jian-Yu Yang, Min-Wei Yang, De-Jun Liu, Yong-Wei Sun, Shu-Heng Jiang, Xue-Li Zhang, Zhi-Gang Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive metastatic disease characterized by an immunosuppressive microenvironment. Here the authors show that a subset of P2RX1-negative neutrophils with immunosuppressive properties accumulate i
Externí odkaz:
https://doaj.org/article/e5c9f48dd02248afa64c33593ecd5868
Autor:
Zheng Wu, Ying Lin, Li-Min Liu, Yan-Li Hou, Wei-Ting Qin, Lei Zhang, Shu-Heng Jiang, Qin Yang, Yong-Rui Bai
Publikováno v:
Journal of Immunology Research, Vol 2022 (2022)
Background. The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) plays critical functions in innate immune responses via the production of the second messenger cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), which stimulates the ad
Externí odkaz:
https://doaj.org/article/73c7cdbebc9d4377b340a25aa3c46b0e