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Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus

Autor: Dzyurkevich M., Babkov D., Shtyrlin N., Mayka O., Iksanova A., Vassiliev P., Balakin K., Spasov A., Tarasov V., Barreto G., Shtyrlin Y., Aliev G.

Publikováno v: SCOPUS-2017-7-1-SID85034806962

© 2017 The Author(s). Glucokinase is one of the promising targets for glucose-lowering agents, and the development of GK activators are now considered as one of the most promising strategies for the treatment of type 2 diabetes mellitus. In this wor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::66ecfccfca75a6166039096ec6ee38d9
https://openrepository.ru/article?id=706156

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Wittig reactions of a bis-triphenylphosphonium pyridoxine derivative

Autor: Pugachev M., Bulatov T., Nguyen T., Pavelyev R., Gnezdilov O., Lodochnikova O., Islamov D., Kataeva O., Balakin K., Shtyrlin Y.

Publikováno v: SCOPUS00404039-2017-58-8-SID85009865424

© 2017 Elsevier LtdWittig reactions of a bis-triphenylphosphonium pyridoxine derivative with five aromatic and aliphatic aldehydes led to a series of mono- and bis-alkenyl substituted products. The reactions also demonstrated unusual reactivity patt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::34986a1ce761bae673a3069143bb4a5f
https://openrepository.ru/article?id=221657

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Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans -Stilbenes

Autor: Pugachev M., Nguyen T., Bulatov T., Pavelyev R., Iksanova A., Bondar O., Balakin K., Shtyrlin Y.

Publikováno v: SCOPUS20909063-2017-2017-SID85024475756

© 2017 Mikhail V. Pugachev et al. A series of trans-6-phenylethenyl substituted pyridoxine derivatives, novel bioisosteric analogs of drugs based on trans-stilbene scaffold, were synthesized using the Wittig reaction of a bis-triphenylphosphonium py

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::579e375cf0cf170733715c5247ddf913
https://openrepository.ru/article?id=706293

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Synthesis and antitumor activity of pyridoxine monoalkenyl derivatives

Autor: Pugachev M., Pavelyev R., Nguyen T., Iksanova A., Lodochnikova O., Shtyrlin Y.

Publikováno v: SCOPUS10665285-2016-65-2-SID85013778759

© 2016, Springer Science+Business Media New York.A convenient method for the synthesis of pyridoxine alkenyl derivatives by the Wittig reaction of [(2,8-dimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl]triphenylphosphonium chloride with aldehydes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::16fa1488b6b5e3c8067d9322f64a8595
https://openrepository.ru/article?id=62103

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Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets?

Autor: Nikitina E., Zeldi M., Pugachev M., Sapozhnikov S., Shtyrlin N., Kuznetsova S., Evtygin V., Bogachev M., Kayumov A., Shtyrlin Y.

Publikováno v: SCOPUS-2016-32-1-SID84988809971
SCOPUS09593993-2016-32-1-SID84951972923

© 2015, Springer Science+Business Media Dordrecht. We studied the effects of quaternary bis-phosphonium and bis-ammonium salts of pyridoxine with lipophilic substituents on the survival and morphology of Staphylococcus aureus cells. We found that, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1b5978a2fe41258933334f39ec8f1c8d
https://openrepository.ru/article?id=61005

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Synthesis of a new quaternary phosphonium salt: NMR study of the conformational structure and dynamics

Autor: Aganova O., Galiullina L., Aganov A., Shtyrlin N., Pugachev M., Strel'nik A., Koshkin S., Shtyrlin Y., Klochkov V.

Publikováno v: SCOPUS07491581-2016-54-4-SID84959467804
SCOPUS07491581-2015-SID84949968526

Copyright © 2015 John Wiley & Sons, Ltd.A novel phosphonium salt based on pyridoxine was synthesized. Conformational analysis of the compound in solution was performed using dynamic NMR experiments and calculations. The obtained results revealed som

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7c4dedce6e3c454a33639e7011b7d366
https://openrepository.ru/article?id=51931

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Stereochemistry of hexachlorocyclopentadiene [4+2]-cycloaddition to 2-substituted 4,7-dihydro-1,3-dioxepins

Autor: Pavelyev R., Vafina R., Lodochnikova O., Galiullina A., Romanova E., Balakin K., Shtyrlin Y.

Publikováno v: SCOPUS00404039-2016-57-35-SID84979754048

© 2016 Elsevier LtdExperimental investigation of hexachlorocyclopentadiene [4+2]-cycloaddition to 2-substituted 4,7-dihydro-1,3-dioxepins revealed an atypical stereochemical effect. Clear experimental evidence was obtained that more bulky C2 substit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4869c8fb8fb7c378d1e5eab76b881dc4
https://openrepository.ru/article?id=678266

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