Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shruti Gaggar"'
Autor:
Susanne Brix, Ismail Gögenur, Mustafa Bulut, Lasse Bremholm Hansen, Mikail Gögenur, Lukas Balsevicius, Nesibe Colak, Tobias Freyberg Justesen, Anne-Marie Kanstrup Fiehn, Marianne Bøgevang Jensen, Kathrine Høst-Rasmussen, Britt Cappelen, Shruti Gaggar, Asma Tajik, Jawad Ahmad Zahid, Astrid Louise Bjørn Bennedsen, Tommaso Del Buono D’Ondes, Hans Raskov, Susanne Gjørup Sækmose, Ali Salanti
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background In colorectal cancer, the effects of immune checkpoint inhibitors are mostly limited to patients with deficient mismatch repair tumors, characterized by a high grade infiltration of CD8+T cells. Interventions aimed at increasing intratumor
Externí odkaz:
https://doaj.org/article/94c6d0a449c0483fae25a919b3acb501
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-16 (2022)
Abstract Neutrophils are central mediators of innate and adaptive immunity and first responders to tissue damage. Although vital to our health, their activation, function, and resolution are critical to preventing chronic inflammation that may contri
Externí odkaz:
https://doaj.org/article/7eaa2f78c92445f3bac313b5e7e77672
Publikováno v:
Cancers, Vol 15, Iss 7, p 2057 (2023)
As the core component of all organs, the extracellular matrix (ECM) is an interlocking macromolecular meshwork of proteins, glycoproteins, and proteoglycans that provides mechanical support to cells and tissues. In cancer, the ECM can be remodelled i
Externí odkaz:
https://doaj.org/article/74c17c94f8bf4f90863b772f35237fe4
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Our understanding of the tumor microenvironment (TME), including the interplay between tumor cells, stromal cells, immune cells, and extracellular matrix components, is mandatory for the innovation of new therapeutic approaches in cancer. The cell-ce
Externí odkaz:
https://doaj.org/article/40dcc8a4cb1b4a96b0ec8b91f459a3e8
Publikováno v:
Raskov, H, Gaggar, S, Tajik, A, Orhan, A & Gögenur, I 2023, ' Metabolic switch in cancer – Survival of the fittest ', European Journal of Cancer, vol. 180, pp. 30-51 . https://doi.org/10.1016/j.ejca.2022.11.025
Cell metabolism is characterised by the highly coordinated conversion of nutrients into energy and biomass. In solid cancers, hypoxia, nutrient deficiencies, and tumour vasculature are incompatible with accelerated anabolic growth and require a rewir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee2a32d390ab2fe17f31707a55280b8
https://curis.ku.dk/portal/da/publications/metabolic-switch-in-cancer--survival-of-the-fittest(ca442500-a65e-4c85-bca8-b0b426521cf8).html
https://curis.ku.dk/portal/da/publications/metabolic-switch-in-cancer--survival-of-the-fittest(ca442500-a65e-4c85-bca8-b0b426521cf8).html
Autor:
Mikail Gögenur, Lukas Balsevicius, Mustafa Bulut, Nesibe Colak, Tobias Freyberg Justesen, Anne-Marie Kanstrup Fiehn, Marianne Bøgevang Jensen, Kathrine Høst-Rasmussen, Britt Cappelen, Shruti Gaggar, Asma Tajik, Jawad Ahmad Zahid, Astrid Louise Bjørn Bennedsen, Tommaso Del Buono D’Ondes, Hans Raskov, Susanne Gjørup Sækmose, Lasse Bremholm Hansen, Ali Salanti, Susanne Brix, Ismail Gögenur
Publikováno v:
Gögenur, M, Balsevicius, L, Bulut, M, Colak, N, Justesen, T F, Fiehn, A-M K, Jensen, M B, Høst-Rasmussen, K, Cappelen, B, Gaggar, S, Tajik, A, Zahid, J A, Bennedsen, A L B, D'Ondes, T D B, Raskov, H, Sækmose, S G, Hansen, L B, Salanti, A, Brix, S & Gögenur, I 2023, ' Neoadjuvant intratumoral influenza vaccine treatment in patients with proficient mismatch repair colorectal cancer leads to increased tumor infiltration of CD8+ T cells and upregulation of PD-L1: a phase 1/2 clinical trial ', Journal for ImmunoTherapy of Cancer, vol. 11, no. 5, e006774 . https://doi.org/10.1136/jitc-2023-006774
BackgroundIn colorectal cancer, the effects of immune checkpoint inhibitors are mostly limited to patients with deficient mismatch repair tumors, characterized by a high grade infiltration of CD8+T cells. Interventions aimed at increasing intratumora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f85e690fee350b864f70c666637cc7
https://orbit.dtu.dk/en/publications/53ac1b78-d29d-4cff-95bd-e42a69c92f71
https://orbit.dtu.dk/en/publications/53ac1b78-d29d-4cff-95bd-e42a69c92f71
Publikováno v:
Cancer Letters. 520:233-242
The detection and killing of neoplastic cells require coordination of a variety of antitumor effector cells. Natural killer (NK) cells of the innate immune system are at the forefront of the body's defense systems and evidence suggests that the infil