Výsledky vyhledávání - "Shruti D. Raut"

Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers

Autor: Marlene C. Hinton, Hua Zhou, Dongyu Sun, Ulrike Philippar, Peter Spacciapoli, Hongmin Chen, Shruti D. Raut, G. Naumov, Joey L. Methot, Alessia Petrocchi, Alan Hruza, My Sam Mansueto, Jongwon Lim, Joon Jung, Elizabeth Helen Kelley, Susan E. Hill, Phieng Siliphaivanh, John Maclean

Publikováno v: Journal of Medicinal Chemistry. 59:6501-6511

The ERK/MAPK pathway plays a central role in the regulation of critical cellular processes and is activated in more than 30% of human cancers. Specific BRAF and MEK inhibitors have shown clinical efficacy in patients for the treatment of BRAF-mutant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fbdf8648dfc5a05619ca77897359083
https://doi.org/10.1021/acs.jmedchem.6b00708

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Fibrin-mediated lentivirus gene transfer: implications for lentivirus microarrays

Autor: Shruti D. Raut, Stelios T. Andreadis, Pedro Lei, Roshan M. Padmashali

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 144(2)

We employed fibrin hydrogel as a bioactive matrix for lentivirus mediated gene transfer. Fibrin-mediated gene transfer was highly efficient and exhibited strong dependence on fibrinogen concentration. Efficient gene transfer was achieved with fibrino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be0c6b48f0b2364d86ddadddc85b369
https://pubmed.ncbi.nlm.nih.gov/20153386

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