Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Shruti, Lal"'
Autor:
Weiqun Liu, Meredith Leong, Evan McCartney-Melstad, Colin McKinlay, Adrienne Sallets, Samuel Deutsch, Gunasekaran Kannan, Gowrisudha Adusumilli, Srinivasa Bandi, Shruti Lal, Ray Low, Ole Audun Haabeth, Pei-Ken Hsu, Kimmy Ferry, Anustha Sharma, Jenna Triplett
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/ef4bd54da34f407b9342f695526b3476
Autor:
Jonathan R. Brody, Zhihao Zhuang, Janet A. Sawicki, Jordan M. Winter, Andrew Napper, Matthew Gehrmann, Charles J. Yeo, Agnieska K. Witkiewicz, Joseph A. Cozzitorto, Shruti Lal, Kathy Miller, Yongxing Ai, Qin Liang, Vanessa A. Talbott, Renée M. Tholey, Zoë A. Norris, Yu Peng, Richard A. Burkhart
PDF file - 59K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6065f2d773f29c29792c0beabd9cf72a
https://doi.org/10.1158/1541-7786.22509771.v1
https://doi.org/10.1158/1541-7786.22509771.v1
Autor:
Jonathan R. Brody, Zhihao Zhuang, Janet A. Sawicki, Jordan M. Winter, Andrew Napper, Matthew Gehrmann, Charles J. Yeo, Agnieska K. Witkiewicz, Joseph A. Cozzitorto, Shruti Lal, Kathy Miller, Yongxing Ai, Qin Liang, Vanessa A. Talbott, Renée M. Tholey, Zoë A. Norris, Yu Peng, Richard A. Burkhart
PDF file - 28K, S1. Cell growth in a high USP11 expression cell line (PL5) following siRNA treatment targeting USP11.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56828542c7b6db72d2b4961f3ceb462b
https://doi.org/10.1158/1541-7786.22509774
https://doi.org/10.1158/1541-7786.22509774
Autor:
Jonathan R. Brody, Dan A. Dixon, Jordan M. Winter, Paul M. Campbell, Charles J. Yeo, Avinoam Nevler, Cinthya Y. Lowder, Austin Goetz, Eric Londin, Matthew C. Stout, Carmella Romeo, Nicole C. Mambelli-Lisboa, Saswati N. Chand, Ranjan Preet, Mahsa Zarei, Edwin C. Cheung, Shruti Lal
Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States, whereas colorectal cancer is the third most common cancer. The RNA-binding protein HuR (ELAVL1) supports a pro-oncogenic network in gastr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893d87f75b99f780caa6bbbab5107d71
https://doi.org/10.1158/1541-7786.c.6540345
https://doi.org/10.1158/1541-7786.c.6540345
Autor:
Jordan M. Winter, Jonathan R. Brody, Christian M. Metallo, Erin L. Seifert, Eric R. Londin, Charles J. Yeo, Wei Jiang, Joseph A. Cozzitorto, Masaya Jimbo, Saswati N. Chand, Fernando F. Blanco, Cynthia Moffat, Nicole C. Mambelli-Lisboa, Katerina Dukleska, Ali Vaziri-Gohar, Avinoam Nevler, Seth J. Parker, Shruti Lal, Mahsa Zarei
Table S5: Results of RNA sequencing in PDA cell lines (HS-766T and MiaPaCa2) with each modulated by CRISPR/Cas9 to delete HuR expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407575c68ba038659eca4790c467ac6a
https://doi.org/10.1158/0008-5472.22414922
https://doi.org/10.1158/0008-5472.22414922
Autor:
Jordan M. Winter, Jonathan R. Brody, Christian M. Metallo, Erin L. Seifert, Eric R. Londin, Charles J. Yeo, Wei Jiang, Joseph A. Cozzitorto, Masaya Jimbo, Saswati N. Chand, Fernando F. Blanco, Cynthia Moffat, Nicole C. Mambelli-Lisboa, Katerina Dukleska, Ali Vaziri-Gohar, Avinoam Nevler, Seth J. Parker, Shruti Lal, Mahsa Zarei
Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived microenvironment. Here we illustrate how such conditions promote chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC). Glucose or glutamine withdr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fca4173cfff5730bbe12fdcc153e4f7
https://doi.org/10.1158/0008-5472.c.6509120.v1
https://doi.org/10.1158/0008-5472.c.6509120.v1
Autor:
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand
PARG rescue in HuR silenced cells restores PARPi resistance. Small-molecule inhibition of HuR prevents its cytoplasmic accumulation, abrogates PARG mRNA regulation and increases PARPi sensitivity, independent of DDR status.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceb7e3ef902e2e70ae482b29c4ff897
https://doi.org/10.1158/0008-5472.22416705
https://doi.org/10.1158/0008-5472.22416705
Autor:
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand
Doxycycline induction of HuR silencing in MIA PaCa-2 cells (sh290) downregulates PARG expression in vitro and tumor growth in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cbca6f975a7e2018f6b0b818443577
https://doi.org/10.1158/0008-5472.22416702.v1
https://doi.org/10.1158/0008-5472.22416702.v1
Autor:
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand
HuR silencing results in downregulation of PARG expression, which prevents efficient removal of PAR polymers with or without PARPi stress. Expression and function of other PAR removing enzymes is not affected with HuR silencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d30a8c36dd805071ddb659360d7ff19
https://doi.org/10.1158/0008-5472.22416711
https://doi.org/10.1158/0008-5472.22416711
Autor:
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand
HuR directly binds and regulates poly-ADP ribose glycohydrolase mRNA expression particularly under PARPi stress, but doesn't affect expression of other PAR polymerases or hydrolyzing enzymes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391bd3a9966c19991c83d520996223e4
https://doi.org/10.1158/0008-5472.22416717.v1
https://doi.org/10.1158/0008-5472.22416717.v1