Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shruti, Athale"'
Autor:
Swati Patel, Moti Chapagain, Clifford Mason, Matthew Gingrich, Shruti Athale, Wendy Ribble, Teresa Hoang, Joshua Day, Xicheng Sun, Thale Jarvis, Urs A Ochsner, David Howe, Tawanda Gumbo
Publikováno v:
Journal of Antimicrobial Chemotherapy. 77:2876-2885
Background Listeriosis is an orphan disease, which is nevertheless fatal in immunocompromised people. CRS0540 is a novel PolC DNA polymerase inhibitor that has demonstrated good in vitro and in vivo activity against Listeria monocytogenes. Methods Ro
Autor:
Moti, Chapagain, Jotam G, Pasipanodya, Shruti, Athale, Claude, Bernal, Rachel, Trammell, David, Howe, Tawanda, Gumbo
Publikováno v:
Journal of Antimicrobial Chemotherapy. 77:1694-1705
Objectives The standard of care (SOC) for the treatment of pulmonary Mycobacterium avium complex (MAC) disease (clarithromycin, rifabutin, and ethambutol) achieves sustained sputum conversion rates of only 54%. Thus, new treatments should be prioriti
Autor:
Julia H Shin, Steven A. Gilbert, Vikram R. Rao, Betsy J. Barnes, Lih-Ling Lin, Ken Dower, Virginia Pascual, Bruce A. Jacobson, Iain Kilty, Jean J Beebe, Tatyana Andreyeva, Bruce L. Homer, Joanne Brodfuehrer, Weiyong Sun, Martin Hegen, Simeon Ramsey, M Nusrat Sharif, Margaret Fleming, Mera Tilley, Heng Liu, Aaron Winkler, Aiping Jiao, Saurav De, Shruti Athale, Peter T. Symanowicz, Ju Wang, Spencer I. Danto
Publikováno v:
Arthritis & Rheumatology. 73:2206-2218
Objective To investigate the role of PF-06650833, a highly potent and selective small-molecule inhibitor of interleukin-1-associated kinase 4 (IRAK4), in autoimmune pathophysiology in vitro, in vivo, and in the clinical setting. Methods Rheumatoid ar
Publikováno v:
Open Forum Infectious Diseases. 9
Background Based on meta-analyses the current standard-of-care regimen (SOC) for Mycobacterium avium complex (MAC) lung disease achieves a sustained sputum conversion rate of ∼54% at best. Epetraborole (EBO) is a boron-containing oral inhibitor of
Autor:
Devyani Deshpande, Jotam G. Pasipanodya, Thearith Koeuth, John F. Antiabong, Tawanda Gumbo, Katherine R Martin, Shruti Athale, Shashikant Srivastava, Pooi S Lee, Keertan Dheda, Johanna S. van Zyl
Publikováno v:
The Journal of Infectious Diseases. 219:975-985
Drug-resistant tuberculosis represents a global emergency, requiring new drugs. We found that minocycline was highly potent in laboratory strains of Mycobacterium tuberculosis and that 30 drug-susceptible and multidrug/extensively drug-resistant clin
Autor:
Manjari Chandra, Bojana Domic, Virginia Pascual, Simone Caielli, Lorien Nassi, Cheng-han Chung, Preetha Balasubramanian, Hideki Ueno, Romain Banchereau, Shruti Athale, Julie Fuller, Joseph X. Zhou, Zhaohui Xu, Elise Murat, Tracey Wright, Marilynn Punaro, Diogo Troggian Veiga, Jacques Banchereau, Jeanine Baisch, Duygu Ucar, Katie Stewart, Lynnette Walters
Publikováno v:
Nature Medicine. 25:75-81
Understanding the mechanisms underlying autoantibody development will accelerate therapeutic target identification in autoimmune diseases such as systemic lupus erythematosus (SLE)1. Follicular helper T cells (TFH cells) have long been implicated in
Autor:
Yuanyuan Wang, LuAnn Thompson-Snipes, Virginia Pascual, Jacques Banchereau, Shruti Athale, Karolina Palucka, Romain Banchereau
Publikováno v:
Science Translational Medicine. 9
Human dendritic cells (DCs) play a fundamental role in the initiation of long-term adaptive immunity during vaccination against influenza. Understanding the early response of human DCs to vaccine exposure is thus essential to determine the nature and
Autor:
Jacques Banchereau, Jeanine Baisch, Elise Murat, Marilynn Punaro, Sandra Clayton, Shruti Athale, Cristiana Guiducci, Romain Banchereau, Karolina Palucka, Kate Phelps, Simone Caielli, Tracey Wright, Bojana Domic, Virginia Pascual, Manjari Chandra, Mei Gong
Publikováno v:
The Journal of experimental medicine. 213(5)
Autoantibodies against nucleic acids and excessive type I interferon (IFN) are hallmarks of human systemic lupus erythematosus (SLE). We previously reported that SLE neutrophils exposed to TLR7 agonist autoantibodies release interferogenic DNA, which
Publikováno v:
Nature Medicine. 16:224-227
Smallpox was eradicated by vaccination with a related poxvirus, vaccinia virus, which was applied to superficially injured skin in a process called scarification. Recombinant poxvirus–based vaccines are attractive candidates for protecting against
Autor:
Damien Chaussabel, Abhilasha Cheruku, Chun I. Yu, Hui Xu, Ingrid Gayet, Karolina Palucka, Gerlinde Obermoser, Jacques Banchereau, Isabelle Berthier, Nicole Baldwin, Yaming Xue, Romain Banchereau, Shruti Athale, Sangkon Oh, Octavio Ramilo, Alma-Martina Cepika, Virginia Pascual, Derek Blankenship, Marina Ohouo, Lu Ann Snipes, Yuanyuan Wang, Patrick Metang
Publikováno v:
Nature Communications
The mechanisms by which microbial vaccines interact with human APCs remain elusive. Herein, we describe the transcriptional programs induced in human DCs by pathogens, innate receptor ligands and vaccines. Exposure of DCs to influenza, Salmonella ent