Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Shruthi Viswanath"'
Autor:
Vikas Tiwari, Shruthi Viswanath
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract IFITM3 is a transmembrane protein that confers innate immunity. It has been established to restrict entry of multiple viruses. Overexpression of IFITM3 has been shown to be associated with multiple cancers, implying IFITM3 to be good therape
Externí odkaz:
https://doaj.org/article/87745169507e48a1af750d3d55fe52c8
CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation
Autor:
Axel F Brilot, Andrew S Lyon, Alex Zelter, Shruthi Viswanath, Alison Maxwell, Michael J MacCoss, Eric G Muller, Andrej Sali, Trisha N Davis, David A Agard
Publikováno v:
eLife, Vol 10 (2021)
Microtubule (MT) nucleation is regulated by the γ-tubulin ring complex (γTuRC), conserved from yeast to humans. In Saccharomyces cerevisiae, γTuRC is composed of seven identical γ-tubulin small complex (γTuSC) sub-assemblies, which associate hel
Externí odkaz:
https://doaj.org/article/d01c66d5a03743a7bf70f392cb7c8a89
Autor:
Satwik Pasani, Shruthi Viswanath
Publikováno v:
Life, Vol 11, Iss 11, p 1183 (2021)
Integrative modeling of macromolecular assemblies requires stochastic sampling, for example, via MCMC (Markov Chain Monte Carlo), since exhaustively enumerating all structural degrees of freedom is infeasible. MCMC-based methods usually require tunin
Externí odkaz:
https://doaj.org/article/146a89bf19c14d43b278ae360592ade9
Publikováno v:
Bioinformatics. 38:3837-3839
Integrative modeling of macromolecular structures usually results in an ensemble of models that satisfy the input information. The model precision, or variability among these models is estimated globally, i.e., a single precision value is reported fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68027ec6ca3145d8dc42a3ef06fc1ebd
https://doi.org/10.1093/bioinformatics/btac400
https://doi.org/10.1093/bioinformatics/btac400
Autor:
Andrej Sali, Ignacia Echeverria, Shruthi Viswanath, Ilan E. Chemmama, Daniel J. Saltzberg, Ben Webb
Publikováno v:
Protein Sci
Biology is advanced by producing structural models of biological systems, such as protein complexes. Some systems are recalcitrant to traditional structure determination methods. In such cases, it may still be possible to produce useful models by int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259e47087338ec788b222ff90d8de0fa
https://doi.org/10.1002/pro.3995
https://doi.org/10.1002/pro.3995
Autor:
Michael J. Landsberg, Matthew J Jackman, Jason Low, Shreyas Mahesh Arvindekar, Shruthi Viswanath, Joel P. Mackay
Publikováno v:
Protein science : a publication of the Protein Society. 31(9)
The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin-modifying assembly that regulates gene expression and DNA damage repair. Despite its importance, limited structural information describing the complete NuRD complex is available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80574d0e5ec160b6adc3b490412d7ad
https://pubmed.ncbi.nlm.nih.gov/36040254
https://pubmed.ncbi.nlm.nih.gov/36040254
Optimizing model representation for integrative structure determination of macromolecular assemblies
Autor:
Shruthi Viswanath, Andrej Sali
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 2
Integrative structure determination of macromolecular assemblies requires specifying the representation of the modeled structure, a scoring function for ranking alternative models based on diverse types of data, and a sampling method for generating t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb986ce3d787b8aa631b0be6575ea1f2
https://doi.org/10.1073/pnas.1814649116
https://doi.org/10.1073/pnas.1814649116
CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation
Autor:
Andrew S. Lyon, Michael J. MacCoss, Eric G D Muller, Alex Zelter, Shruthi Viswanath, Axel F. Brilot, Trisha N. Davis, David A. Agard, Andrej Sali, Alison M Maxwell
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Microtubule (MT) nucleation is regulated by the γ-tubulin ring complex (γTuRC), conserved from yeast to humans. In Saccharomyces cerevisiae, γTuRC is composed of seven identical γ-tubulin small complex (γTuSC) sub-assemblies, which associate hel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdb76111604271b162ae2cec9ef0f6d
https://elifesciences.org/articles/65168
https://elifesciences.org/articles/65168
Autor:
Axel F. Brilot, Michael J. MacCoss, David A. Agard, Andrej Sali, Andrew S. Lyon, Trisha N. Davis, Shruthi Viswanath, Alex Zelter, Eric G D Muller, Alison M Maxwell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaa3efd620e3497d9fd2618a633ee619
https://doi.org/10.7554/elife.65168.sa2
https://doi.org/10.7554/elife.65168.sa2
Publikováno v:
Biophysical journal, vol 113, iss 11
Modeling of macromolecular structures involves structural sampling guided by a scoring function, resulting in an ensemble of good-scoring models. By necessity, the sampling is often stochastic, and must be exhaustive at a precision sufficient for acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69add8a1199a499324e70c1bc976b6ff
https://doi.org/10.1016/j.bpj.2017.10.005
https://doi.org/10.1016/j.bpj.2017.10.005