Echinocandin Resistance in Has Broad Implications for Membrane Lipid Perturbations That Influence Drug-Target Interactions

Autor: Shruthi Satish, David S Perlin

Publikováno v: Microbiology Insights, Vol 12 (2019)

Echinocandin drugs target the fungal enzyme β-(1,3)-glucan synthase (GS), which is required for the synthesis of cell wall component β-(1,3)- d -glucan. They are first-line therapy for Candida infections but are increasingly used as second-line the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::1b10b3c1c0d157209323b550df9f76f2
https://doaj.org/article/6a8af8caaa1a44f9a9dda6bbc07ec991

Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)- d -Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus

Autor: Olaf Kniemeyer, Cristina Jiménez-Ortigosa, Thomas Krüger, Shruthi Satish, Yanan Zhao, Steven Park, David W. Denning, Min Hee Lee, Enriko Dolgov, David S. Perlin, Axel A. Brakhage

Publikováno v: mBio, Vol 10, Iss 3 (2019)
mBio, Vol 10, Iss 3, p e00779-19 (2019)
Satish, S, Jiménez-Ortigosa, C, Zhao, Y, Lee, M H, Dolgov, E, Krüger, T, Park, S, Denning, D W, Kniemeyer, O, Brakhage, A A & Perlin, D S 2019, ' Stress-induced changes in the lipid microenvironment of β-(1,3)-d-glucan synthase cause clinically important echinocandin resistance in Aspergillus fumigatus ', mBio, vol. 10, no. 3, e00779-19 . https://doi.org/10.1128/mBio.00779-19
mBio

Resistance to first-line triazole antifungal agents among Aspergillus species has prompted the use of second-line therapy with echinocandins. As the number of Aspergillus-infected patients treated with echinocandins is rising, clinical observations o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f59c14f85bb200ade739c790f7b854
https://doi.org/10.1128/mbio.00779-19

Discovery of MRSA active antibiotics using primary sequence from the human microbiome

Autor: Henry Zebroski, Joel S. Freundlich, Xavier Vila-Farrés, Boojala Vijay B. Reddy, David S. Perlin, Shruthi Satish, Mark Jaskowski, Daigo Inoyama, Louis J. Cohen, Emma A. Gordon, Zachary Charlop-Powers, Ricardo Gallardo-Macias, Melinda A. Ternei, John Chu, Steven Park, Sean F. Brady

Publikováno v: Nature chemical biology

Here we present a natural product discovery approach, whereby structures are bioinformatically predicted from primary sequence and produced by chemical synthesis (synthetic-bioinformatic natural products, syn-BNPs), circumventing the need for bacteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d68a6056a5768d19b384cb075149fea
https://doi.org/10.1038/nchembio.2207

Echinocandin Resistance in Aspergillus fumigatus Has Broad Implications for Membrane Lipid Perturbations That Influence Drug-Target Interactions

Autor: Shruthi Satish, David S. Perlin

Publikováno v: Microbiology Insights. 12:117863611989703

Echinocandin drugs target the fungal enzyme β-(1,3)-glucan synthase (GS), which is required for the synthesis of cell wall component β-(1,3)-d-glucan. They are first-line therapy for Candida infections but are increasingly used as second-line thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b70bc83f1a0f67fbaf693d11ad9fde62
https://doi.org/10.1177/1178636119897034

Abstract 2712: ISC-4, a novel inhibitor of hedgehog-Gli signaling, inhibits growth of CSC and CTC of melanoma patients

Autor: Deepkamal N. Karelia, Shantu Amin, Arun Sharma, Jay Sharma, Natalee Amezcua, Patrick Cleary, Esteban Gomez, Cristian Sharma, Shruthi Satish, Mariam Navel, Michael Sharma, Dhimant Desai, Jitesh P. Jani, Michael Prez

Publikováno v: Cancer Research. 74:2712-2712

Melanoma is one of the most aggressive cancers, and its incidence and mortality rate are on rise since no treatment options are available for metastatic disease. Recent evidences from in vitro and in vivo studies have demonstrated that aberrant react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ca638de0fc629356f982a81ad16fe2a
https://doi.org/10.1158/1538-7445.am2014-2712