Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shrusti S. Patel"'
Autor:
Ella N. Hoogenboezem, Shrusti S. Patel, Justin H. Lo, Ashley B. Cavnar, Lauren M. Babb, Nora Francini, Eva F. Gbur, Prarthana Patil, Juan M. Colazo, Danielle L. Michell, Violeta M. Sanchez, Joshua T. McCune, Jinqi Ma, Carlisle R. DeJulius, Linus H. Lee, Jonah C. Rosch, Ryan M. Allen, Larry D. Stokes, Jordan L. Hill, Kasey C. Vickers, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The high potential of siRNAs to silence oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, divalent lipid-conjugated siRNAs are optimized for in situ binding to albumin to improve pharmacokinetics
Externí odkaz:
https://doaj.org/article/a8ad79f8d57c45aeac75fe1a848bd947
Autor:
Ella N. Hoogenboezem, Shrusti S. Patel, Ashley B. Cavnar, Justin H. Lo, Lauren M. Babb, Nora Francini, Prarthana Patil, Juan M. Colazo, Danielle L. Michell, Violeta M. Sanchez, Joshua T. McCune, Jinqi Ma, Carlisle R. DeJulius, Linus H. Lee, Jonah C. Rosch, Ryan M. Allen, Larry D. Stokes, Jordan L. Hill, Kasey C. Vickers, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
bioRxiv
The high potential for therapeutic application of siRNAs to silence traditionally undruggable oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, siRNAs were optimized forin situbinding to albumin through C1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed437d3b4e1884a99c1762f14a4e284b
https://doi.org/10.1101/2023.02.14.528574
https://doi.org/10.1101/2023.02.14.528574
Autor:
Shrusti S. Patel, Ella N. Hoogenboezem, Fang Yu, Carlisle R. DeJulius, R. Brock Fletcher, Alex G. Sorets, Fiona K. Cherry, Justin H. Lo, Mariah G. Bezold, Nora Francini, Richard d’Arcy, Jordan E. Brasuell, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
Biomaterials. 297:122098
Autor:
Shrusti S. Patel, Ella N. Hoogenboezem, Fang Yu, Alex G. Sorets, Fiona K. Cherry, Justin H. Lo, Nora Francini, Richard A. d'Arcy, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
Cancer Research. 83:2706-2706
Triple negative breast cancers (TNBCs) are aggressive malignancies with a high rate of recurrence even after neoadjuvant chemotherapy (NAC) and resection. Nearly 50% of NAC-treated TNBC patients harboring residual disease display mutations in the pho
Autor:
Adam Hartstone-Rose, Ann F. Ramsdell, Shrusti S. Patel, Anna Dvorkin-Gheva, John A. Hassell, Daping Fan, Huda I Atiya, Rachel L Parker, Johnie Hodge
Publikováno v:
Anticancer Res
Background Low success rates in oncology drug development are prompting re-evaluation of preclinical models, including orthotopic tumor engraftment. In breast cancer models, tumor cells are typically injected into mouse mammary fat pads (MFP). Howeve
Autor:
Evan B. Glass, Allyson R. King, Isom B. Kelly, Alyssa M. Hasty, Prarthana Patil, Todd D. Giorgio, Bryan R. Dollinger, Fang Yu, Sean K. Bedingfield, Rachel E. Miles, Shrusti S. Patel, Meredith A. Jackson, Danielle D. Liu, Ella N. Hoogenboezem, Craig L. Duvall, Matthew A. Cottam
Publikováno v:
Biomaterials
In vivonanocarrier-associated toxicity is a significant and poorly understood hurdle to clinical translation of siRNA nanomedicines. In this work, we demonstrate that platelet activating factor (PAF), an inflammatory lipid mediator, plays a key role
Autor:
Atiya HI; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, U.S.A., Dvorkin-Gheva A; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, ON, Canada., Hassell J; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, ON, Canada., Patel S; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, U.S.A., Parker RL; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, U.S.A., Hartstone-Rose A; Department of Biological Sciences, North Carolina State University, Raleigh, NC, U.S.A., Hodge J; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, U.S.A., Fan D; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, U.S.A., Ramsdell AF; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, U.S.A. ann.ramsdell@uscmed.sc.edu.; Program in Women's and Gender Studies, College of Arts and Sciences, University of South Carolina, Columbia, SC, U.S.A.; Department of Regenerative Medicine and Cell Biology, and Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, U.S.A.
Publikováno v:
Anticancer research [Anticancer Res] 2019 May; Vol. 39 (5), pp. 2277-2287.