Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Shrujna Patel"'
Autor:
Erica Tsang, Velda X. Han, Chloe Flutter, Sarah Alshammery, Brooke A. Keating, Tracey Williams, Brian S. Gloss, Mark E. Graham, Nader Aryamanesh, Ignatius Pang, Melanie Wong, David Winlaw, Michael Cardamone, Shekeeb Mohammad, Wendy Gold, Shrujna Patel, Russell C. Dale
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105156- (2024)
Summary: Background: Kabuki syndrome (KS) is a genetic disorder caused by DNA mutations in KMT2D, a lysine methyltransferase that methylates histones and other proteins, and therefore modifies chromatin structure and subsequent gene expression. Keton
Externí odkaz:
https://doaj.org/article/706dcecdfb3d41058e9433023d709cb7
Autor:
Russell C. Dale, Terrence Thomas, Shrujna Patel, Velda X. Han, Kavitha Kothur, Christopher Troedson, Sachin Gupta, Deepak Gill, Stephen Malone, Michaela Waak, Sophie Calvert, Gopinath Subramanian, P. Ian Andrews, Tejaswi Kandula, Manoj P. Menezes, Simone Ardern‐Holmes, Shekeeb Mohammad, Sushil Bandodkar, Jingya Yan
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 8, Pp 1417-1432 (2023)
Abstract Objective Infection‐triggered encephalopathy syndromes (ITES) are potentially devastating neuroinflammatory conditions. Although some ITES syndromes have recognisable MRI neuroimaging phenotypes, there are otherwise few biomarkers of disea
Externí odkaz:
https://doaj.org/article/1c41c2d648974bcc8a098e644408d090
Autor:
Jingya Yan, Kavitha Kothur, Shekeeb Mohammad, Jason Chung, Shrujna Patel, Hannah F. Jones, Brooke A. Keating, Velda X. Han, Richard Webster, Simone Ardern-Holmes, Jayne Antony, Manoj P. Menezes, Esther Tantsis, Deepak Gill, Sachin Gupta, Tejaswi Kandula, Hugo Sampaio, Michelle A. Farrar, Christopher Troedson, P Ian Andrews, Sekhar C. Pillai, Benjamin Heng, Gilles J. Guillemin, Anna Guller, Sushil Bandodkar, Russell C. Dale
Publikováno v:
EBioMedicine, Vol 91, Iss , Pp 104589- (2023)
Summary: Background: Defining the presence of acute and chronic brain inflammation remains a challenge to clinicians due to the heterogeneity of clinical presentations and aetiologies. However, defining the presence of neuroinflammation, and monitori
Externí odkaz:
https://doaj.org/article/f3f98b36f0cb49b9aa7418bacef1fbf5
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2023)
Mental health and neurodevelopmental disorders are extremely common across the lifespan and are characterized by a complicated range of symptoms that affect wellbeing. There are relatively few drugs available that target disease mechanisms for any of
Externí odkaz:
https://doaj.org/article/5c6b64a4cc094bc593e4a27bad65cbe0
Autor:
Sarah Alshammery, Shrujna Patel, Hannah F. Jones, Velda X. Han, Brian S. Gloss, Wendy A. Gold, Russell C. Dale
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Neurodevelopmental disorders (NDDs), including autism-spectrum disorders (ASD) and Tourette syndrome (TS) are common brain conditions which often co-exist, and have no approved treatments targeting disease mechanisms. Accumulating literature implicat
Externí odkaz:
https://doaj.org/article/c2b7ea73d2c447baa2bd6de608a8ae36
Autor:
Jingya Yan, Kavitha Kothur, Emily A. Innes, Velda X. Han, Hannah F. Jones, Shrujna Patel, Erica Tsang, Richard Webster, Sachin Gupta, Christopher Troedson, Manoj P. Menezes, Jayne Antony, Simone Ardern-Holmes, Esther Tantsis, Shekeeb Mohammad, Louise Wienholt, Ananda S. Pires, Benjamin Heng, Gilles J. Guillemin, Anna Guller, Deepak Gill, Sushil Bandodkar, Russell C. Dale
Publikováno v:
EBioMedicine, Vol 84, Iss , Pp 104280- (2022)
Summary: Background: Epileptic (previously infantile) spasms is the most common epileptic encephalopathy occurring during infancy and is frequently associated with abnormal neurodevelopmental outcomes. Epileptic spasms have a diverse range of known (
Externí odkaz:
https://doaj.org/article/a996c30a8b944c29b682c22fe3ffea37
Autor:
Velda X. Han, Shrujna Patel, Hannah F. Jones, Timothy C. Nielsen, Shekeeb S. Mohammad, Markus J. Hofer, Wendy Gold, Fabienne Brilot, Samantha J. Lain, Natasha Nassar, Russell C. Dale
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Inflammation is increasingly recognized as a cause or consequence of common problems of humanity including obesity, stress, depression, pollution and disease states such as autoimmunity, asthma, and infection. Maternal immune activation (MIA
Externí odkaz:
https://doaj.org/article/c22563d0167e48929f5f14fb25cecc6a
Autor:
Shrujna Patel, Sandra Y Y Fok, Holly Stefen, Tamara Tomanić, Esmeralda Parić, Rosanna Herold, Merryn Brettle, Aleksandra Djordjevic, Thomas Fath
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187979 (2017)
Genetically encoded filamentous actin probes, Lifeact, Utrophin and F-tractin, are used as tools to label the actin cytoskeleton. Recent evidence in several different cell types indicates that these probes can cause changes in filamentous actin dynam
Externí odkaz:
https://doaj.org/article/8daefc42a1734114af745acf474d542a
Autor:
Charlotte E. Verrall, Shrujna Patel, Leksi Travitz, Jason Tchieu, Russel C. Dale, Nadine A. Kasparian, David S. Winlaw, Gillian M. Blue
Publikováno v:
Translational Pediatrics. 12:768-786
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d35e94625b29a0e597a2649f13c213ee
https://doi.org/10.21037/tp-22-687
https://doi.org/10.21037/tp-22-687
Publikováno v:
Nature Reviews Neurology. 17:564-579
Maternal health during pregnancy plays a major role in shaping health and disease risks in the offspring. The maternal immune activation hypothesis proposes that inflammatory perturbations in utero can affect fetal neurodevelopment, and evidence from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6a6ec8d58a66e7716f06c7c1a41e743
https://doi.org/10.1038/s41582-021-00530-8
https://doi.org/10.1038/s41582-021-00530-8