Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Shrouq I, Farah"'
Publikováno v:
Biochemical and Biophysical Research Communications. 591:31-36
2-Arachidonoylglycerol (2-AG) is the most potent and abundant endocannabinoid that acts as a full agonist at the cannabinoid 1 (CB1) and 2 (CB2) receptors. It serves as a substrate for several serine hydrolases, including monoacylglycerol lipase (MGL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4aac30aab0c9d93113a9e13253da18
https://doi.org/10.1016/j.bbrc.2021.12.105
https://doi.org/10.1016/j.bbrc.2021.12.105
Autor:
Shakiru O. Alapafuja, Jodi Anne T. Wood, Dimitrios N. Pelekoudas, Christina Miyabe Shields, Alexandros Makriyannis, Girija Rajarshi, Nicholas Thomas Perry, Spiro Pavlopoulos, Honrao Chandrashekhar, Michael S. Malamas, Khadijah A. Mohammad, Alexander Zvonok, Jay A. A. West, Shrouq I. Farah
Publikováno v:
Journal of Medicinal Chemistry. 64:5956-5972
N-Acylethanolamines are signaling lipid molecules implicated in pathophysiological conditions associated with inflammation and pain. N-Acylethanolamine acid amidase (NAAA) favorably hydrolyzes lipid palmitoylethanolamide, which plays a key role in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84652a99798fe8f73174af31f7603ad9
https://doi.org/10.1021/acs.jmedchem.1c00076
https://doi.org/10.1021/acs.jmedchem.1c00076
Autor:
Michael S, Malamas, Spiro, Pavlopoulos, Shakiru O, Alapafuja, Shrouq I, Farah, Alexander, Zvonok, Khadijah A, Mohammad, Jay, West, Nicholas Thomas, Perry, Dimitrios N, Pelekoudas, Girija, Rajarshi, Christina, Shields, Honrao, Chandrashekhar, Jodi, Wood, Alexandros, Makriyannis
Publikováno v:
Journal of medicinal chemistry. 64(9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fd60869f9a6246787f03aec9443e1e0
https://pubmed.ncbi.nlm.nih.gov/33900772
https://pubmed.ncbi.nlm.nih.gov/33900772
Autor:
Michael S. Malamas, Joseph Anderson, Karen L.G. Farizatto, JodiAnne T. Wood, Alexandros Makriyannis, Michael F. Almeida, Ben A. Bahr, Catherine M. Weerts, Shrouq I. Farah, Manjunath Lamani, Vidyanand G. Shukla
Publikováno v:
Bioorganicmedicinal chemistry. 27(23)
FAAH inhibitors offer safety advantages by augmenting the anandamide levels "on demand" to promote neuroprotective mechanisms without the adverse psychotropic effects usually seen with direct and chronic activation of the CB1 receptor. FAAH is an enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215f978efc5bcb8abf910890d7f20da0
https://pubmed.ncbi.nlm.nih.gov/31629610
https://pubmed.ncbi.nlm.nih.gov/31629610
Autor:
Alex Straiker, Shrouq I. Farah, Khadijah A. Mohammad, Alexandros Makriyannis, Catherine M. Weerts, Michael Speziale, Samantha Hilston, Nikolai Zvonok, Manjunath Lamani, Michael S. Malamas, Honrao Chandrashekhar, Christina Yume Miyabe, Maya Ploss
Publikováno v:
Bioorganic & Medicinal Chemistry. :116244
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fbdb4175ba780f0d4f5591bc121849e
https://doi.org/10.1016/j.bmc.2021.116244
https://doi.org/10.1016/j.bmc.2021.116244
Autor:
Christina Yume Miyabe, Jay A. A. West, Michael S. Malamas, Girija Rajarshi, Dimitrios N. Pelekoudas, Nicholas Thomas Perry, Honrao Chandrashekhar, Manjunath Lamani, Spiro Pavlopoulos, Alexandros Makriyannis, Shrouq I. Farah
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115195
N-acylethanolamine acid amidase (NAAA) inhibition represents an exciting novel approach to treat inflammation and pain. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5aa3e4b1fb2cb8c97076d649464e699
https://doi.org/10.1016/j.bmc.2019.115195
https://doi.org/10.1016/j.bmc.2019.115195
Autor:
Evangelos Theodorou, Jonathan N. Glickman, Katharine A. Germansky, Alan C. Moss, Efi Kokkotou, Shrouq I. Farah, Alexandros Makriyannis, Michael S. Malamas
Publikováno v:
Gastroenterology. 156:S-65
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12f5f8ef7d2d1d0d8063e2657654e966
https://doi.org/10.1016/s0016-5085(19)36948-3
https://doi.org/10.1016/s0016-5085(19)36948-3