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Both lymphatic and distant metastases arise through cancer cell migration and colonization of ectopic sites. Nonetheless, the two metastasis types are associated with significantly different clinical outcomes, suggesting that distinct biological mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f01fe0eff84360f8b998e0fd081385
https://doi.org/10.1101/828913
https://doi.org/10.1101/828913
Autor:
I-Hsiu Lee, Alexander A. Farahani, Gang Liu, Jochen K. Lennerz, Emma C. E. Wassenaar, Simon R.V. Knott, Wei-Ting Hung, Peter Giunta, Johannes G. Reiter, Onno Kranenburg, Hetal D. Marble, Sebastian Degner, Kamila Naxerova, Shriya Nagpal, Martin S. Taylor, William R. Jeck
Publikováno v:
Nat Genet
Nature genetics
Nature genetics
Genetic diversity among metastases is poorly understood but contains important information about disease evolution at secondary sites. Here we investigate inter- and intra-lesion heterogeneity for two types of metastases that associate with different