Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Shrividhya Srinivasan"'
Autor:
Benjamin Angulo, Shrividhya Srinivasan, Benjamin J Bolival, Gonzalo H Olivares, Allyson C Spence, Margaret T Fuller
Publikováno v:
PLoS Genetics, Vol 15, Iss 6, p e1008187 (2019)
Active adult stem cells maintain a bipotential state with progeny able to either self-renew or initiate differentiation depending on extrinsic signals from the surrounding microenvironment. However, the intrinsic gene regulatory networks and chromati
Externí odkaz:
https://doaj.org/article/89bf95e74aca46b4b0b4e29fef5162f8
Publikováno v:
PLoS Genetics, Vol 9, Iss 11, p e1003903 (2013)
Many tissues are sustained by adult stem cells, which replace lost cells by differentiation and maintain their own population through self-renewal. The mechanisms through which adult stem cells maintain their identity are thus important for tissue ho
Externí odkaz:
https://doaj.org/article/4a7c932db3904ae9abe0669f4fb0bd37
Publikováno v:
PLoS Genetics, Vol 4, Iss 10, p e1000217 (2008)
Polycomb and trithorax group proteins regulate cellular pluripotency and differentiation by maintaining hereditable states of transcription. Many Polycomb and trithorax group proteins have been implicated in the covalent modification or remodeling of
Externí odkaz:
https://doaj.org/article/4fb9d133fd754ef39578729973b12e94
Autor:
Zineb Mounir, Mark R. Lackner, Shih-Min A. Huang, Yannick Waumans, Mark Kockx, Koen M. Marien, Sarah Lynagh, Paul R. McAdam, Max Bylesjo, Adrian R. Carr, Daniel L. Halligan, Sanjeev Mariathasan, Edward E. Kadel, Kobe C. Yuen, Thomas Holcomb, Shrividhya Srinivasan, Joseph Castillo, Marie-Claire Wagle
supplementary tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35073d94791ff25b6df92ad645e456c1
https://doi.org/10.1158/2326-6066.22543155.v1
https://doi.org/10.1158/2326-6066.22543155.v1
Supplementary Fig 1 from Tumor Fusion Burden as a Hallmark of Immune Infiltration in Prostate Cancer
Autor:
Zineb Mounir, Mark R. Lackner, Shih-Min A. Huang, Yannick Waumans, Mark Kockx, Koen M. Marien, Sarah Lynagh, Paul R. McAdam, Max Bylesjo, Adrian R. Carr, Daniel L. Halligan, Sanjeev Mariathasan, Edward E. Kadel, Kobe C. Yuen, Thomas Holcomb, Shrividhya Srinivasan, Joseph Castillo, Marie-Claire Wagle
TMB, TFB and CRPC scores across individual samples and disease stages and crosscorrelation analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9124389488a6abd15abccd6bbf624d28
https://doi.org/10.1158/2326-6066.22543161.v1
https://doi.org/10.1158/2326-6066.22543161.v1
Autor:
Zineb Mounir, Mark R. Lackner, Shih-Min A. Huang, Yannick Waumans, Mark Kockx, Koen M. Marien, Sarah Lynagh, Paul R. McAdam, Max Bylesjo, Adrian R. Carr, Daniel L. Halligan, Sanjeev Mariathasan, Edward E. Kadel, Kobe C. Yuen, Thomas Holcomb, Shrividhya Srinivasan, Joseph Castillo, Marie-Claire Wagle
Prostate cancer is the second leading cause of cancer-related death in men. Despite having a relatively lower tumor mutational burden than most tumor types, multiple gene fusions such as TMPRSS2:ERG have been characterized and linked to more aggressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e25bc093bffce3f195eb2bcc044f33
https://doi.org/10.1158/2326-6066.c.6550161.v1
https://doi.org/10.1158/2326-6066.c.6550161.v1
Autor:
Zineb Mounir, Mark R. Lackner, Jennifer M. Giltnane, Vicki Plaks, Shih-Min A. Huang, Steven Magnuson, F. Anthony Romero, Andrew Glibicky, Thomas Holcomb, Somayeh S. Tarighat, Matthew P. Stokes, Wendell Jones, Katherine E. Hutchinson, Bonnie Liu, Jeffrey Eastham-Anderson, Melissa Gonzalez Edick, Sangeeta Jayakar, Marie-Claire Wagle, Ron McCord, Shrividhya Srinivasan, Christopher Lowe, Esther Wu, Joseph Castillo
Supplementary figure 3 shows H3K27 acetylation ChIPseq QC analyses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477ddd9560eda30f5c026406d5682a9e
https://doi.org/10.1158/0008-5472.22421168.v1
https://doi.org/10.1158/0008-5472.22421168.v1
Autor:
Zineb Mounir, Mark R. Lackner, Jennifer M. Giltnane, Vicki Plaks, Shih-Min A. Huang, Steven Magnuson, F. Anthony Romero, Andrew Glibicky, Thomas Holcomb, Somayeh S. Tarighat, Matthew P. Stokes, Wendell Jones, Katherine E. Hutchinson, Bonnie Liu, Jeffrey Eastham-Anderson, Melissa Gonzalez Edick, Sangeeta Jayakar, Marie-Claire Wagle, Ron McCord, Shrividhya Srinivasan, Christopher Lowe, Esther Wu, Joseph Castillo
Regulatory T cells (Treg) are immunosuppressive and negatively impact response to cancer immunotherapies. CREB-binding protein (CBP) and p300 are closely related acetyltransferases and transcriptional coactivators. Here, we evaluate the mechanisms by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00dfda38464bfe249a1e9c6500c6cdae
https://doi.org/10.1158/0008-5472.c.6510854.v1
https://doi.org/10.1158/0008-5472.c.6510854.v1
Autor:
Thomas Holcomb, F. Anthony Romero, Jeffrey Eastham-Anderson, Shrividhya Srinivasan, Vicki Plaks, Mark R. Lackner, Somayeh S. Tarighat, Esther Wu, Katherine E. Hutchinson, Matthew P. Stokes, Andrew Glibicky, Ron McCord, Wendell D. Jones, Melissa Gonzalez Edick, Bonnie Liu, Sangeeta K. Jayakar, Marie-Claire Wagle, Joseph Castillo, Jennifer M. Giltnane, Christopher Lowe, Steven Magnuson, Zineb Mounir, Shih-Min A. Huang
Publikováno v:
Cancer Research. 79:3916-3927
Regulatory T cells (Treg) are immunosuppressive and negatively impact response to cancer immunotherapies. CREB-binding protein (CBP) and p300 are closely related acetyltransferases and transcriptional coactivators. Here, we evaluate the mechanisms by
Autor:
Minkyu Jung, Robert Piskol, Amanda R. Moore, Frances Shanahan, Jianping Yin, Hye Sook Han, Yong Sang Hong, Hyeong Seok Lim, Thomas Hunsaker, Darlene Dela Cruz, Zora Modrusan, Liangxuan Zhang, Scott E. Martin, Ehud Segal, Nicholas P. D. Liau, Tae Won Kim, Jeeyun Lee, Christiaan Klijn, Munjeong Choi, Sang Joon Shin, Young Su Noh, Soo Jung Lee, Ivana Yen, Malgorzata Nowicka, Avinashnarayan Venkatanarayan, Yibing Yan, Xin Ye, Shrividhya Srinivasan, Kyu Pyo Kim, Seung Tae Kim, Jin-Soo Kim, Matthew T. Chang, Shiva Malek, Yu Jung Kim, Oakpil Han, Eva Lin, Inhwan Bae, Yoon hee Hong, Jawahar Sudhamsu
Publikováno v:
Nature. 594(7863)
Although RAF monomer inhibitors (type I.5, BRAF(V600)) are clinically approved for the treatment of BRAFV600-mutant melanoma, they are ineffective in non-BRAFV600 mutant cells1–3. Belvarafenib is a potent and selective RAF dimer (type II) inhibitor