Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Shripad V Bhagwat"'
Autor:
Ying Chen, Jeremy McGee, Xianming Chen, Thompson N Doman, Xueqian Gong, Youyan Zhang, Nicole Hamm, Xiwen Ma, Richard E Higgs, Shripad V Bhagwat, Sean Buchanan, Sheng-Bin Peng, Kirk A Staschke, Vipin Yadav, Yong Yue, Hosein Kouros-Mehr
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98293 (2014)
The Cancer Genome Atlas (TCGA) projects have advanced our understanding of the driver mutations, genetic backgrounds, and key pathways activated across cancer types. Analysis of TCGA datasets have mostly focused on somatic mutations and translocation
Externí odkaz:
https://doaj.org/article/a29e5a4806f34d02a21d59875c6c8e59
Autor:
Irem Ozkan-Dagliyan, J. Nathaniel Diehl, Samuel D. George, Antje Schaefer, Bjoern Papke, Kathleen Klotz-Noack, Andrew M. Waters, Craig M. Goodwin, Prson Gautam, Mariaelena Pierobon, Sen Peng, Thomas S.K. Gilbert, Kevin H. Lin, Onur Dagliyan, Krister Wennerberg, Emanuel F. Petricoin, III, Nhan L. Tran, Shripad V. Bhagwat, Ramon V. Tiu, Sheng-Bin Peng, Laura E. Herring, Lee M. Graves, Christine Sers, Kris C. Wood, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107764- (2020)
Summary: We address whether combinations with a pan-RAF inhibitor (RAFi) would be effective in KRAS mutant pancreatic ductal adenocarcinoma (PDAC). Chemical library and CRISPR genetic screens identify combinations causing apoptotic anti-tumor activit
Externí odkaz:
https://doaj.org/article/5756388e183142489ccb4823f8985e8f
Autor:
Sheng-Bin Peng, Sajan Joseph, Ramon V. Tiu, Gregory D. Plowman, Michael J. Rodriguez, Eunice Yuen, Jennie Walgren, Jason Manro, Andrew J. Dropsey, Denis McCann, Xi Rao, Robert D. Van Horn, Meghann Pogue, Xiu-Juan Yuan, Yan Zhai, Bryan Anderson, Wenjuan Wu, Robert S. Flack, Lisa Kindler, Weihua Shen, Matthew Whitesell, Baohui Zhao, Shufen Cai, William T. McMillen, Shripad V. Bhagwat
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d0dc26b8998855020bf945222d1189
https://doi.org/10.1158/1535-7163.22507273.v1
https://doi.org/10.1158/1535-7163.22507273.v1
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ab9e588f7270d239b69faebcc24e90
https://doi.org/10.1158/1535-7163.22506969.v1
https://doi.org/10.1158/1535-7163.22506969.v1
Autor:
Sheng-Bin Peng, Sajan Joseph, Ramon V. Tiu, Gregory D. Plowman, Michael J. Rodriguez, Eunice Yuen, Jennie Walgren, Jason Manro, Andrew J. Dropsey, Denis McCann, Xi Rao, Robert D. Van Horn, Meghann Pogue, Xiu-Juan Yuan, Yan Zhai, Bryan Anderson, Wenjuan Wu, Robert S. Flack, Lisa Kindler, Weihua Shen, Matthew Whitesell, Baohui Zhao, Shufen Cai, William T. McMillen, Shripad V. Bhagwat
In vivo effect of treatment on body weight loss.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952c561d8520c3c104049374b206e09a
https://doi.org/10.1158/1535-7163.22507276.v1
https://doi.org/10.1158/1535-7163.22507276.v1
Autor:
Jonathan A. Pachter, Peter J. Houghton, Lee D. Arnold, Robert Wild, Neil W. Gibson, David M. Epstein, Lorina Dudkin, Mark Bittner, Jennifer Workman, Jennifer Kahler, Christine Mantis, Yan Yao, Andy Cooke, Andrew P. Crew, Prafulla C. Gokhale, Shripad V. Bhagwat
Supplementary Figures 1-9 and Tables 1-3 from Preclinical Characterization of OSI-027, a Potent and Selective Inhibitor of mTORC1 and mTORC2: Distinct from Rapamycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9ab41947de32aae0fe5fca829aab12
https://doi.org/10.1158/1535-7163.22496358.v1
https://doi.org/10.1158/1535-7163.22496358.v1
Autor:
Sheng-Bin Peng, Sajan Joseph, Ramon V. Tiu, Gregory D. Plowman, Michael J. Rodriguez, Eunice Yuen, Jennie Walgren, Jason Manro, Andrew J. Dropsey, Denis McCann, Xi Rao, Robert D. Van Horn, Meghann Pogue, Xiu-Juan Yuan, Yan Zhai, Bryan Anderson, Wenjuan Wu, Robert S. Flack, Lisa Kindler, Weihua Shen, Matthew Whitesell, Baohui Zhao, Shufen Cai, William T. McMillen, Shripad V. Bhagwat
Summary of antitumor activity of LY3214996 and other MAPK pathway inhibitors in cancer models with dominant MAPK pathway alterations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6c4588b08e0998a9a4807fcc3a711c
https://doi.org/10.1158/1535-7163.22507261.v1
https://doi.org/10.1158/1535-7163.22507261.v1
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Although Aurora A, B, and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell-cycle progression. Aurora A depletion primarily leads to mitotic spindle formation defects and consequently prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0aca539a9e32036f4566410352eeff32
https://doi.org/10.1158/1535-7163.c.6538536.v1
https://doi.org/10.1158/1535-7163.c.6538536.v1
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b687d979fb87e1752e656129b11b4a8
https://doi.org/10.1158/1535-7163.22506966
https://doi.org/10.1158/1535-7163.22506966
Autor:
Jonathan A. Pachter, Peter J. Houghton, Lee D. Arnold, Robert Wild, Neil W. Gibson, David M. Epstein, Lorina Dudkin, Mark Bittner, Jennifer Workman, Jennifer Kahler, Christine Mantis, Yan Yao, Andy Cooke, Andrew P. Crew, Prafulla C. Gokhale, Shripad V. Bhagwat
Supplementary Methods and Figure Legends 1-9 from Preclinical Characterization of OSI-027, a Potent and Selective Inhibitor of mTORC1 and mTORC2: Distinct from Rapamycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a574faa50b2771bf5de2007cc92ce22
https://doi.org/10.1158/1535-7163.22496355.v1
https://doi.org/10.1158/1535-7163.22496355.v1