The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels.

Autor: Erik Axelsson, Ingrid Ljungvall, Priyasma Bhoumik, Laura Bas Conn, Eva Muren, Åsa Ohlsson, Lisbeth Høier Olsen, Karolina Engdahl, Ragnvi Hagman, Jeanette Hanson, Dmytro Kryvokhyzha, Mats Pettersson, Olivier Grenet, Jonathan Moggs, Alberto Del Rio-Espinola, Christian Epe, Bruce Taillon, Nilesh Tawari, Shrinivas Mane, Troy Hawkins, Åke Hedhammar, Philippe Gruet, Jens Häggström, Kerstin Lindblad-Toh

Publikováno v: PLoS Genetics, Vol 17, Iss 9, p e1009726 (2021)

Selective breeding for desirable traits in strictly controlled populations has generated an extraordinary diversity in canine morphology and behaviour, but has also led to loss of genetic variation and random entrapment of disease alleles. As a conse

Externí odkaz: https://doaj.org/article/bc00abd03f7a4a5eb45034df9811c21d

The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels

Autor: Shrinivas Mane, Alberto Del Rio-Espinola, Åsa Ohlsson, Åke Hedhammar, Philippe Gruet, Jens Häggström, Mats E. Pettersson, Nilesh R. Tawari, Erik Axelsson, Troy Hawkins, Karolina Engdahl, Lisbeth H. Olsen, Ingrid Ljungvall, Ragnvi Hagman, Dmytro Kryvokhyzha, Olivier Grenet, Jeanette Hanson, Eva Murén, Jonathan G. Moggs, Kerstin Lindblad-Toh, Priyasma Bhoumik, Laura Bas Conn, Christian Epe, Bruce Taillon

Publikováno v: Axelsson, E, Ljungvall, I, Bhoumik, P, Conn, L B, Muren, E, Ohlsson, Å, Olsen, L H, Engdahl, K, Hagman, R, Hanson, J, Kryvokhyzha, D, Pettersson, M, Grenet, O, Moggs, J, Del Rio-Espinola, A, Epe, C, Taillon, B, Tawari, N, Mane, S, Hawkins, T, Hedhammar, Å, Gruet, P, Häggström, J & Lindblad-Toh, K 2021, ' The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels : [+ correction] ', PLOS Genetics, vol. 17, no. 9, e1009726 . https://doi.org/10.1371/journal.pgen.1009726
PLoS Genetics, 17 (9)
PLoS Genetics
PLoS Genetics, Vol 17, Iss 9, p e1009726 (2021)

Selective breeding for desirable traits in strictly controlled populations has generated an extraordinary diversity in canine morphology and behaviour, but has also led to loss of genetic variation and random entrapment of disease alleles. As a conse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da38d6d836f08dd0ce14e097ac93696

The genetic consequences of dog breed formation—Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels.

Autor: Axelsson, Erik¹ (AUTHOR) erik.axelsson@imbim.uu.se, Ljungvall, Ingrid² (AUTHOR), Bhoumik, Priyasma³ (AUTHOR), Conn, Laura Bas¹ (AUTHOR), Muren, Eva¹ (AUTHOR), Ohlsson, Åsa⁴ (AUTHOR), Olsen, Lisbeth Høier⁵ (AUTHOR), Engdahl, Karolina² (AUTHOR), Hagman, Ragnvi² (AUTHOR), Hanson, Jeanette² (AUTHOR), Kryvokhyzha, Dmytro¹ (AUTHOR), Pettersson, Mats¹ (AUTHOR), Grenet, Olivier³ (AUTHOR), Moggs, Jonathan³ (AUTHOR), Del Rio-Espinola, Alberto³ (AUTHOR), Epe, Christian⁶ (AUTHOR), Taillon, Bruce⁶ (AUTHOR), Tawari, Nilesh⁶ (AUTHOR), Mane, Shrinivas⁶ (AUTHOR), Hawkins, Troy⁶ (AUTHOR)

Publikováno v: PLoS Genetics. 9/2/2021, Vol. 17 Issue 9, p1-34. 34p.