Výsledky vyhledávání - "Shrinivas Dumbre"

Synthesis and Structure–Activity Relationship Studies of Benzo[ b ][1,4]oxazin‐3(4 H )‐one Analogues as Inhibitors of Mycobacterial Thymidylate Synthase X

Autor: Michiel Vanmeert, Hannu Myllykallio, Rania Abu El‐Asrar, Jiahong Li, Eveline Lescrinier, Anastasia Parchina, Lia Margamuljana, Hubert F. Becker, Shrinivas Dumbre, Jakub Modranka, Hoai Nguyen, Roeland Vanhoutte, Mayla Salman, Jef Rozenski, Steven De Jonghe, Piet André Maurits Maria Herdewijn

Publikováno v: ChemMedChem
ChemMedChem, Wiley-VCH Verlag, 2019, 14 (6), pp.645-662. ⟨10.1002/cmdc.201800739⟩

Since the discovery of a flavin‐dependent thymidylate synthase (ThyX or FDTS) that is absent in humans but crucial for DNA biosynthesis in a diverse group of pathogens, the enzyme has been pursued for the development of new antibacterial agents aga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bad860f52246e3df6dbc18d33e50352
https://doi.org/10.1002/cmdc.201800739

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