Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Shrilekha Misra"'
Autor:
Janani Ravikrishnan, Daisy Y. Diaz-Rohena, Elizabeth Muhowski, Xiaokui Mo, Tzung-Huei Lai, Shrilekha Misra, Charmelle D. Williams, John Sanchez, Andrew Mitchell, Suresh Satpati, Elizabeth Perry, Tierney Kaufman, Chaomei Liu, Arletta Lozanski, Gerard Lozanski, KerryA Rogers, Adam S. Kittai, Seema A. Bhat, Mary C. Collins, Matthew S. Davids, Nitin Jain, William G. Wierda, Rosa Lapalombella, John C. Byrd, Fenlai Tan, Yi Chen, Yu Chen, Yue Shen, Stephen P. Anthony, Jennifer A. Woyach, Deepa Sampath
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Patients with chronic lymphocytic leukemia (CLL) respond well to initial treatment with the Bcell lymphoma 2 (BCL2) inhibitor venetoclax. Upon relapse, they often retain sensitivity to BCL2 targeting, but durability of response remains a concern. We
Externí odkaz:
https://doaj.org/article/84739096159249b4b8f8ad48426936e4
Autor:
Elizabeth M. Muhowski, Janani Ravikrishnan, Britten Gordon, Lianbo Yu, Shrilekha Misra, Brandi Walker, Sudharshan Eathiraj, Deepa Sampath, Kerry A. Rogers, John C. Byrd, Jennifer A. Woyach
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-5 (2022)
Abstract Inhibitors of B cell receptor (BCR) signaling such as the Bruton’s tyrosine kinase (BTK) inhibitors are effective therapeutics for chronic lymphocytic leukemia (CLL). The first-in-class covalent BTK inhibitor, ibrutinib, produces durable r
Externí odkaz:
https://doaj.org/article/cbd3349984cb4091abe926011ab6ccf0
Autor:
Rajeswara Rao Arasada, Konstantin Shilo, Tadaaki Yamada, Jianying Zhang, Seiji Yano, Rashelle Ghanem, Walter Wang, Shinji Takeuchi, Koji Fukuda, Nobuyuki Katakami, Keisuke Tomii, Fumitaka Ogushi, Yasuhiko Nishioka, Tiffany Talabere, Shrilekha Misra, Wenrui Duan, Paolo Fadda, Mohammad A. Rahman, Patrick Nana-Sinkam, Jason Evans, Joseph Amann, Elena E. Tchekneva, Mikhail M. Dikov, David P. Carbone
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Treatment of EGFR mutant non-small cell lung cancer (NSCLC) often develops resistance to EGFR TKIs. In this study, the authors discover a non-canonical activation of β-catenin signaling through Notch3 as a mechanism of adaptation to and resistance t
Externí odkaz:
https://doaj.org/article/f0b02e3948464f6081e96b751e406253
Publikováno v:
Electronic Journal of Plant Breeding, Vol 1, Iss 3, Pp 346-350 (2010)
Genetic associations and path-coefficient analysis was performed for the 15 economic traits affecting capsaicin content (%)in 38 elite genetic stocks/accessions of chili (Capsicum annuum). The capsaicin content was significantly associated withnumber
Externí odkaz:
https://doaj.org/article/d69786dd24384dbb8beef3aab51cb39e
Publikováno v:
Oncotarget
Triple-negative breast cancer (TNBC) shows limited therapeutic efficacy. PARP inhibitor has been approved to treat advanced BRCA-mutant breast cancer but shows high resistance. Therefore, the development of new therapeutics that sensitize TNBC irresp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1806ba13aa210307b0e02cd60dac0056
https://doi.org/10.18632/oncotarget.27485
https://doi.org/10.18632/oncotarget.27485
Autor:
Gage S. Black, Xiaomeng Huang, Yi Qiao, Szabolcs Tarapcsak, Kerry A. Rogers, Shrilekha Misra, John C. Byrd, Gabor T. Marth, Deborah M. Stephens, Jennifer A. Woyach
Publikováno v:
Blood. 140(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766eb46db554c41f9cb432b6e6667f63
https://pubmed.ncbi.nlm.nih.gov/35476648
https://pubmed.ncbi.nlm.nih.gov/35476648
Autor:
Rashelle Ghanem, Konstantin Shilo, Seiji Yano, Mikhail M. Dikov, Shinji Takeuchi, Koji Fukuda, Jianying Zhang, Elena E. Tchekneva, Joseph M. Amann, Patrick Nana-Sinkam, Yasuhiko Nishioka, Paolo Fadda, Shrilekha Misra, Wenrui Duan, Tiffany Talabere, Jason V. Evans, Fumitaka Ogushi, David P. Carbone, Walter Wang, Rajeswara Rao Arasada, Keisuke Tomii, Nobuyuki Katakami, Mohammad Alinoor Rahman, Tadaaki Yamada
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
EGFR tyrosine kinase inhibitors cause dramatic responses in EGFR-mutant lung cancer, but resistance universally develops. The involvement of β-catenin in EGFR TKI resistance has been previously reported, however, the precise mechanism by which β-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08427a23184a40b5748ecdb7f53d4aca
https://doaj.org/article/f0b02e3948464f6081e96b751e406253
https://doaj.org/article/f0b02e3948464f6081e96b751e406253
Autor:
Tzung-Huei Lai, Stephen P. Anthony, Yu Chen, Shrilekha Misra, Jennifer A. Woyach, Felai Tan, Elizabeth M. Muhowski, John C. Byrd, Deepa Sampath, Yi Chen, Yue Shen, Janani Ravikrishnan, Daisy Diaz Rohena
Publikováno v:
Blood. 138:679-679
Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia, which is characterized by the accumulation of mature CD19+CD5+ B cells that evade apoptosis by upregulating anti-apoptotic BH3 protein, B cell lymphoma protein 2 (Bcl-2). V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::888176ca87be574a25484fd03ac5bf37
https://doi.org/10.1182/blood-2021-151852
https://doi.org/10.1182/blood-2021-151852
Autor:
Alkesh Hada, Andy Ganapathi, Archana Kumari, Shrilekha Misra, V. G. Malathi, Jeevaraj Theboral, Kondeti Subramanyam
Publikováno v:
Acta Physiologiae Plantarum. 40
In this genomic era, soybean has entrenched genomic database which offer an extensive scope for improvement through genetic manipulation, although demand for transgenics soybean with better production and enhanced quality has been handicapped due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa64ee4e41dd2d6eca0849faa4432eed
https://doi.org/10.1007/s11738-018-2608-9
https://doi.org/10.1007/s11738-018-2608-9
Autor:
Michael Niesman, Deepa Sampath, Sean D. Reiff, Jennifer A. Woyach, Amy Lehman, Shrilekha Misra, Kai Zhang, Elizabeth M. Muhowski, James S. Blachly, Rose Mantel, John C. Byrd, Janani Ravikrishnan
Publikováno v:
Blood. 134:2077-2077
Introduction: Treatment of chronic lymphocytic leukemia (CLL) has been transformed by small molecule inhibitors targeting the B-cell receptor (BCR) signaling cascade. The first-in-class small molecule inhibitor of Bruton's Tyrosine Kinase (BTK), ibru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dad1f678b9b33e6bbe0e9554bd92e65f
https://doi.org/10.1182/blood-2019-128871
https://doi.org/10.1182/blood-2019-128871