Zobrazeno 1 - 10
of 678
pro vyhledávání: '"Shrikant, Anant"'
Autor:
David Standing, Prasad Dandawate, Sumedha Gunewardena, Obdulia Covarrubias-Zambrano, Katherine F. Roby, Dineo Khabele, Andrea Jewell, Ossama Tawfik, Stefan H. Bossmann, Andrew K. Godwin, Scott J. Weir, Roy A. Jensen, Shrikant Anant
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-16 (2024)
Abstract Advanced epithelial ovarian cancer (EOC) survival rates are dishearteningly low, with ~25% surviving beyond 5 years. Evidence suggests that cancer stem cells contribute to acquired chemoresistance and tumor recurrence. Here, we show that IRA
Externí odkaz:
https://doaj.org/article/a34cd1f4ae354f69b2bfaed9395015fa
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 1, Pp 20-33 (2024)
Pancreatic cancer remains a serious and deadly disease, impacting people globally. There remain prominent gaps in the current understanding of the disease, specifically regarding the role of the signal transducer and activator of transcription (STAT)
Externí odkaz:
https://doaj.org/article/3c1d10583bd74a18b203b586e15b2602
Autor:
Levi Arnold, Juan Pineda Gomez, Michael Barry, Marrion Yap, Laura Jackson, Thuc Ly, David Standing, Subhash B. Padhye, Bernhard Biersack, Shrikant Anant, Sufi Mary Thomas
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 5, Pp 1104-1121 (2023)
Aim: Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide with a survival rate below fifty percent. Addressing meager therapeutic options, a series of small molecule inhibitors were screened for antitumor efficacy
Externí odkaz:
https://doaj.org/article/ef3a66bf9d4e4aa092912605d8161203
Autor:
Sharon J. Manley, Appolinaire A. Olou, Jarrid L. Jack, Mariana T. Ruckert, R. McKinnon Walsh, Austin E. Eades, Bailey A. Bye, Joe Ambrose, Fanuel Messaggio, Shrikant Anant, Michael N. VanSaun
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-10 (2022)
Abstract Obesity creates a localized inflammatory reaction in the adipose, altering secretion of adipocyte-derived factors that contribute to pathologies including cancer. We have previously shown that adiponectin inhibits pancreatic cancer by antago
Externí odkaz:
https://doaj.org/article/43d48087386f4912a740e0064e1610c6
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
Prolactin (PRL) is a peptide hormone mainly secreted from the anterior pituitary gland. PRL is reported to play a role in pregnancy, mammary gland development, immune modulation, reproduction, and differentiation of islet cells. PRL binds to its rece
Externí odkaz:
https://doaj.org/article/39314eb1c15c4fbe89a35ef0af1b9202
Autor:
Badal C. Roy, Ishfaq Ahmed, Jason Stubbs, Jun Zhang, Thomas Attard, Seth Septer, Danny Welch, Shrikant Anant, Venkatesh Sampath, Shahid Umar
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract Alternative promoter usage generates long and short isoforms (DCLK1-L and DCLK1-S) of doublecortin-like kinase-1 (DCLK1). Tight control of Notch signaling is important to prevent and restitute inflammation in the intestine. Our aim was to in
Externí odkaz:
https://doaj.org/article/d7436833a6ef4b55967dec6aa603e365
Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex
Autor:
Scott J. Weir, Prasad Dandawate, David Standing, Sangita Bhattacharyya, Prabhu Ramamoorthy, Parthasarathy Rangarajan, Robyn Wood, Amanda E. Brinker, Benjamin L. Woolbright, Mehmet Tanol, Tammy Ham, William McCulloch, Michael Dalton, Gregory A. Reed, Michael J. Baltezor, Roy A. Jensen, John A. Taylor, Shrikant Anant
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-20 (2021)
Abstract Ciclopirox (CPX) is an FDA-approved topical antifungal agent that has demonstrated preclinical anticancer activity in a number of solid and hematologic malignancies. Its clinical utility as an oral anticancer agent, however, is limited by po
Externí odkaz:
https://doaj.org/article/d4bbf6c8245447f1b012189797bdb6c4
Autor:
Dharmalingam Subramaniam, Pablo Angulo, Sivapriya Ponnurangam, Prasad Dandawate, Prabhu Ramamoorthy, Pugazhendhi Srinivasan, Tomoo Iwakuma, Scott J. Weir, Katherine Chastain, Shrikant Anant
Publikováno v:
Cell Death and Disease, Vol 11, Iss 2, Pp 1-15 (2020)
Abstract Osteosarcoma (OS) is the most common primary bone tumor that primarily affects children and adolescents. Studies suggested that dysregulation JAK/STAT signaling promotes the development of OS. Cells treated with pimozide, a STAT5 inhibitor s
Externí odkaz:
https://doaj.org/article/5d310a6efbe6464b9de53da6369710ad
Autor:
Badal C. Roy, Ishfaq Ahmed, Jason Stubbs, Jun Zhang, Thomas Attard, Seth Septer, Danny Welch, Shrikant Anant, Venkatesh Sampath, Shahid Umar
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/a94a10ea35b14301b5774411d7344058
Autor:
Sharon J. Manley, Appolinaire A. Olou, Jarrid L. Jack, Mariana T. Ruckert, R. McKinnon Walsh, Austin E. Eades, Bailey A. Bye, Joe Ambrose, Fanuel Messaggio, Shrikant Anant, Michael N. VanSaun
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/6819525613cb489a8f06d4c0d243b2ad