Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Shrijal S. Shah"'
Autor:
Gizelle M. McCarthy, Angelo Blasio, Olivia G. Donovan, Lena B. Schaller, Althea Bock-Hughes, Jose M. Magraner, Jung Hee Suh, Calum F. Tattersfield, Isaac E. Stillman, Shrijal S. Shah, Zsuzsanna K. Zsengeller, Balajikarthick Subramanian, David J. Friedman, Martin R. Pollak
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 8 (2021)
People of recent sub-Saharan African ancestry develop kidney failure much more frequently than other groups. A large fraction of this disparity is due to two coding sequence variants in the APOL1 gene. Inheriting two copies of these APOL1 risk varian
Externí odkaz:
https://doaj.org/article/a287463f226b4e8fbb37835daa607c31
Autor:
Nicholas Mitsiades, Cristian Coarfa, Bin He, Richard Bond, Martin Zimmermann, Sue Anne Chew, Mahitha Rajendran, Warren Fiskus, Christopher Foley, Vijay Kumar Eedunuri, John Shou, Shrijal S. Shah, Kimal Rajapakshe, Chuandong Geng
Reciprocal gene set enrichment analysis reveals that SPOP F102C, F133V, and F133L mutants have similar effects on the PC transcriptome (S1); AR Activity Score of PC cells expressing wt or mutant SPOPs (S2); Effects of wt-SPOP and PC-associated SPOP m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adcc7389b85478b69a7deebb69737ab
https://doi.org/10.1158/0008-5472.22403420.v1
https://doi.org/10.1158/0008-5472.22403420.v1
Autor:
Nicholas Mitsiades, Cristian Coarfa, Bin He, Richard Bond, Martin Zimmermann, Sue Anne Chew, Mahitha Rajendran, Warren Fiskus, Christopher Foley, Vijay Kumar Eedunuri, John Shou, Shrijal S. Shah, Kimal Rajapakshe, Chuandong Geng
Description of additional methods and procedures used in the study. Also includes Supplemental References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474cc917697a851d3cdda471c7d608a0
https://doi.org/10.1158/0008-5472.22403417.v1
https://doi.org/10.1158/0008-5472.22403417.v1
Autor:
Nicholas Mitsiades, Cristian Coarfa, Bin He, Richard Bond, Martin Zimmermann, Sue Anne Chew, Mahitha Rajendran, Warren Fiskus, Christopher Foley, Vijay Kumar Eedunuri, John Shou, Shrijal S. Shah, Kimal Rajapakshe, Chuandong Geng
Legends for Supplemental Figures S1-S12 and Supplemental Table S1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd90c3e3c2df27cd775aafa5fcbf381
https://doi.org/10.1158/0008-5472.22403423.v1
https://doi.org/10.1158/0008-5472.22403423.v1
Autor:
Nicholas Mitsiades, Cristian Coarfa, Bin He, Richard Bond, Martin Zimmermann, Sue Anne Chew, Mahitha Rajendran, Warren Fiskus, Christopher Foley, Vijay Kumar Eedunuri, John Shou, Shrijal S. Shah, Kimal Rajapakshe, Chuandong Geng
Primers used for PCR cloning and qPCR assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abefc9e3b640bfc4f2e69ec96c0d0089
https://doi.org/10.1158/0008-5472.22403414.v1
https://doi.org/10.1158/0008-5472.22403414.v1
Autor:
Daniel Blackler, Martin R. Pollak, Leny Dias, Herbert Lannon, David J. Friedman, Seth L. Alper, Shrijal S Shah
Publikováno v:
Kidney Int
The apolipoprotein L1 (APOL1) risk variants G1 and G2 are associated with high rates of kidney disease in African Americans in genetic studies. However, our understanding of APOL1 biology has lagged far behind. Here we report that engineering G1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35055efd0870ab0496c665141b82975
https://doi.org/10.1016/j.kint.2019.07.010
https://doi.org/10.1016/j.kint.2019.07.010
Autor:
David J. Friedman, Martin R. Pollak, Shrijal S Shah, Seth L. Alper, Herbert Lannon, Leny Dias, Jia-Yue Zhang
Publikováno v:
Journal of the American Society of Nephrology. 30:2355-2368
Background Genetic Variants in Apolipoprotein L1 (APOL1) are associated with large increases in CKD rates among African Americans. Experiments in cell and mouse models suggest that these risk-related polymorphisms are toxic gain-of-function variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe20ec10f494ca57639ecd3bf0d66d14
https://doi.org/10.1681/asn.2019020114
https://doi.org/10.1681/asn.2019020114
Autor:
Shrijal S, Shah, Herbert, Lannon, Leny, Dias, Jia-Yue, Zhang, Seth L, Alper, Martin R, Pollak, David J, Friedman
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Genetic Variants in Apolipoprotein L1 (APOL1) are associated with large increases in CKD rates among African Americans. Experiments in cell and mouse models suggest that these risk-related polymorphisms are toxic gain-of-function variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8f2c17ce2efe3d935e330944b0719c72
https://pubmed.ncbi.nlm.nih.gov/31558683
https://pubmed.ncbi.nlm.nih.gov/31558683
Autor:
Shrijal S. Shah, Junaith S. Mohamed, John Shou, Christopher Foley, Warren Fiskus, Kimal Rajapakshe, Cristian Coarfa, Vijay Kumar Eedunuri, Chuandong Geng, Sue Anne Chew, Nicholas Mitsiades, Bert W. O'Malley
Publikováno v:
Oncogene. 35:2345-2356
MicroRNAs are important epigenetic regulators of protein expression by triggering degradation of target mRNAs and/or inhibiting their translation. Dysregulation of microRNA expression has been reported in several cancers, including prostate cancer (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd7c3a7b8eab17cb582295e4942eaa1
https://doi.org/10.1038/onc.2015.295
https://doi.org/10.1038/onc.2015.295
Autor:
Richard A. Bond, Nicholas Mitsiades, Martin Zimmermann, Sue Anne Chew, Christopher Foley, Vijay Kumar Eedunuri, Shrijal S. Shah, Cristian Coarfa, Warren Fiskus, Chuandong Geng, Kimal Rajapakshe, John Shou, Mahitha Rajendran, Bin He
Publikováno v:
Cancer Research. 74:5631-5643
Somatic missense mutations in the substrate-binding pocket of the E3 ubiquitin ligase adaptor SPOP are present in up to 15% of human prostate adenocarcinomas, but are rare in other malignancies, suggesting a prostate-specific mechanism of action. SPO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e4d584adaf5614486976ee1626f426
https://doi.org/10.1158/0008-5472.can-14-0476
https://doi.org/10.1158/0008-5472.can-14-0476