Enhancing saliva diagnostics: The impact of amylase depletion on MALDI-ToF MS profiles as applied to COVID-19

Autor: Zane LaCasse, Prajkta Chivte, Kari Kress, Venkata Devesh R. Seethi, Joshua Bland, Hamed Alhoori, Shrihari S. Kadkol, Elizabeth R. Gaillard

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 31, Iss , Pp 59-71 (2024)

Introduction: Human saliva contains a wealth of proteins that can be monitored for disease diagnosis and progression. Saliva, which is easy to collect, has been extensively studied for the diagnosis of numerous systemic and infectious diseases. Howev

Externí odkaz: https://doaj.org/article/79aa196a1bfd42958c3b3f6f71618f55

NGS Analysis of Clonality and Minimal Residual Disease in a Patient with Concurrent Richter’s Transformation and CLL/SLL

Autor: Shrihari S. Kadkol, Joshua Bland, Ashley Kavanaugh, Hongyu Ni, Vijeyaluxmi Nehru, David Peace

Publikováno v: Case Reports in Hematology, Vol 2021 (2021)

B-cell lymphomas are neoplastic proliferations of clonal B lymphocytes. Clonality is generally determined by PCR amplification of VDJ rearrangements in the IgH heavy chain or VJ rearrangements in Igκ/Igλ light chain genes followed by capillary elec

Externí odkaz: https://doaj.org/article/f68019a3b3ad4bfdb414e46cb2ccec93

MALDI-ToF protein profiling as a potential rapid diagnostic platform for COVID-19

Autor: Pratool Bharti, Prajkta Chivte, Elizabeth R. Gaillard, Venkata Devesh Reddy Seethi, Shrihari S. Kadkol, Zane LaCasse, Joshua Bland

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab
Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 21, Iss, Pp 31-41 (2021)

More than a year after the COVID-19 pandemic was declared, the need still exists for accurate, rapid, inexpensive and non-invasive diagnostic methods that yield high specificity and sensitivity towards the current and newly emerging SARS-CoV-2 strain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577dd0efd6335d910041863dffc117ee
http://europepmc.org/articles/PMC8426322

Tumor stiffness is unrelated to myosin light chain phosphorylation in cancer cells.

Autor: Hui-Jun Yu, Leonid A Serebryannyy, Madeline Fry, Madelyne Greene, Olga Chernaya, Wen-Yang Hu, Teng-Leong Chew, Nadim Mahmud, Shrihari S Kadkol, Sarah Glover, Gail Prins, Zuzana Strakova, Primal de Lanerolle

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79776 (2013)

Many tumors are stiffer than their surrounding tissue. This increase in stiffness has been attributed, in part, to a Rho-dependent elevation of myosin II light chain phosphorylation. To characterize this mechanism further, we studied myosin light cha

Externí odkaz: https://doaj.org/article/b7cdede7dfa544b09dc154618a68221a

Mitogen-Activated Protein Kinase Signaling Pathway in Cutaneous Melanoma: An Updated Review

Autor: Andres M. Acosta, Shrihari S. Kadkol

Publikováno v: Archives of Pathology & Laboratory Medicine. 140:1290-1296

The mitogen-activated protein kinase (MAPK) signaling pathway is a cascade of protein kinases that act in a sequential and predominantly linear fashion, albeit displaying some cross talk with other signaling cascades. Mutations in proteins integral t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9005d8509939231cd7a7d910e28e14
https://doi.org/10.5858/arpa.2015-0475-rs