Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Shri N. Giri"'
Publikováno v:
Pharmacology & Pharmacy. :238-247
Tumor necrosis factor-alpha (TNF-α) is a potent inflammatory cytokine and its exaggerated production has been implicated in acute, chronic and autoimmune inflammatory diseases. Proteinaceous and non-proteinaceous anti-TNF-α agents have been develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9299a220fb9a70142f9a28c32048c83
https://doi.org/10.4236/pp.2011.24031
https://doi.org/10.4236/pp.2011.24031
Autor:
Ken J. Grattendick, Amy E Poulin Braim, Melinda H. MacDonald, M. L. Bruss, Solomon B. Margolin, Shri N. Giri
Publikováno v:
American Journal of Veterinary Research. 70:1031-1042
Objective—To characterize effects of IV administration of pirfenidone on clinical, biochemical, and hematologic variables and circulating tumor necrosis factor (TNF)-α concentrations in horses after infusion of a low dose of endotoxin. Animals—1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4643231896f99d4e3b5bcd459fe8168f
https://doi.org/10.2460/ajvr.70.8.1031
https://doi.org/10.2460/ajvr.70.8.1031
Autor:
Shri N. Giri, Scott D Stanley, Jill K Giri, Melinda H. MacDonald, Amy E Poulin Braim, M. L. Bruss
Publikováno v:
American Journal of Veterinary Research. 69:952-960
Objective—To characterize the plasma pharmacokinetics and clinical effects of pirfenidone administered IV in healthy horses. Animals—6 adult horses. Procedures—A 15 mg/kg dose of pirfenidone was administered IV over 5 minutes. Physical variable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740269a5d87b1b45d54d80f15818a470
https://doi.org/10.2460/ajvr.69.7.952
https://doi.org/10.2460/ajvr.69.7.952
Autor:
Kendra C. Decile, Shri N. Giri, Edward S. Schelegle, Kent E. Pinkerton, Jim K. Mansoor, Jennifer M. Bratt, William F. Walby, Harinder Grewal, Solomon B. Margolin
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 20:660-668
Pirfenidone was administered to sensitized Brown Norway rats prior to a series of ovalbumin challenges. Airway hyperresponsiveness, inflammatory cell infiltration, mucin and collagen content, and the degree of epithelium and smooth muscle staining fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08297f341ce8289fc751f62760703b3d
https://doi.org/10.1016/j.pupt.2006.07.005
https://doi.org/10.1016/j.pupt.2006.07.005
Publikováno v:
Multiple Sclerosis Journal. 11:149-158
Currently, there are no approved treatments for secondary progressive multiple sclerosis (MS) that stabilize or reverse the neurological disabilities associated with this disease. Oral pirfenidone was found to stabilize and overcome the disabilities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3668c2095a36b31cab48b0639f3075b1
https://doi.org/10.1191/1352458505ms1134oa
https://doi.org/10.1191/1352458505ms1134oa
Publikováno v:
Biochemical Pharmacology. 64:517-525
Renal fibrosis is a complication of kidney injury and can contribute to organ failure. Currently, there are no drugs for the treatment of renal fibrosis. Pirfenidone (PD) has been proven to have antifibrotic effects in animal models of fibrosis. We t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cff3a1f1c428d45c207154ab4c8bf4
https://doi.org/10.1016/s0006-2952(02)01213-3
https://doi.org/10.1016/s0006-2952(02)01213-3
Publikováno v:
Experimental Lung Research. 28:405-417
Transforming growth factor-beta (TGF-beta) plays a pivotal role in an exaggerated synthesis and accumulation of collagen in fibrotic disorders of many organs. We have previously demonstrated that repeated intratracheal (IT) instillation of TGF-beta s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2400b2ca3b31906b8e3e36246b440f57
https://doi.org/10.1080/01902140290096700
https://doi.org/10.1080/01902140290096700
Autor:
Solomon B. Margolin, Jozsef Lango, Alan R. Buckpitt, Dexter Morin, Yan Xie, Qingjian Wang, Shri N. Giri
Publikováno v:
Biopharmaceutics & Drug Disposition. 23:203-211
The present study describes the pharmacokinetics and metabolism of pirfenidone (PD), a compound which has been shown to have significant antifibrotic effects in rodent models of pulmonary and cardiac fibrosis. Despite the fact that this compound is c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3b83cc9198b2cad5f6ad7266932b80
https://doi.org/10.1002/bdd.311
https://doi.org/10.1002/bdd.311
Publikováno v:
Research communications in molecular pathology and pharmacology.
Septic shock results from a systemic host response to infection, in particular, and is associated with multiorgan dysfunction (MOD). Effective preventive measures against organ failure are essential as it is the cumulative burden of MOD that invariab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::413c861b3b3a2eb4d51b3f13e8a4203d
https://pubmed.ncbi.nlm.nih.gov/25022029
https://pubmed.ncbi.nlm.nih.gov/25022029
Publikováno v:
Archives of Biochemistry and Biophysics. 379:109-118
The ryanodine-sensitive calcium channels, also called ryanodine receptors, are intracellular Ca(2+)-release channels that have been shown to bind the neutral plant alkaloid ryanodine with nanomolar affinity. The activity of the skeletal muscle (RyR1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098e9867202a449aa4b0435ebed012be
https://doi.org/10.1006/abbi.2000.1850
https://doi.org/10.1006/abbi.2000.1850