Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shreyosree Chatterjee"'
Autor:
Dale L. Boger, Daisuke Ogasawara, Julia M. Bittencourt, Enrique Saez, Shreyosree Chatterjee, C. Godio, Ara Sukiasyan, Andrea Galmozzi, Jerome Eberhardt, Benjamin F. Cravatt, Michael D. Cameron, Stefano Forli, Woojoo Kim, Tyler Johns, Dennis W. Wolan, Seiya Kitamura, Bernard P. Kok, Sean M. Kim, Janice H Xu, Srijana Ghimire
Publikováno v:
Nature chemical biology
Activity-based protein profiling (ABPP) has been used extensively to discover and optimize selective inhibitors of enzymes. Here, we show that ABPP can also be implemented to identify the converse – small-molecule enzyme activators. Using a kinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70dc3c8b39f89d1adac0d0c4f299a568
http://europepmc.org/articles/PMC7442688
http://europepmc.org/articles/PMC7442688
Autor:
Benjamin F. Cravatt, Shreyosree Chatterjee, Dale L. Boger, Srijana Ghimire, Katerina Otrubova
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:1693-1703
A series of N-acyl pyrazoles was examined as candidate serine hydrolase inhibitors in which the active site acylating reactivity and the leaving group ability of the pyrazole could be tuned not only through the nature of the acyl group (reactivity: a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9163729fd60a22e86c6a7617c75bc900
https://doi.org/10.1016/j.bmc.2019.03.020
https://doi.org/10.1016/j.bmc.2019.03.020
Publikováno v:
Tetrahedron Letters. 60:1956-1958
A three-step convergent synthesis of an immunostimulatory oxylipin was developed using an olefin cross metathesis approach. The alkene fragments were prepared in two steps from commercially available starting materials with high stereoselectivity. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce03e650d12cf6ae49b3aa3d7fec1d38
https://doi.org/10.1016/j.tetlet.2019.06.040
https://doi.org/10.1016/j.tetlet.2019.06.040
Publikováno v:
The Journal of Organic Chemistry. 80:9967-9972
2,2,6,6-Tetramethylpiperidinyl-masked 1,2-diols exhibited stereochemistry-dependent hydroxyl proton chemical shifts: ca. 7 ppm for the syn diastereomer and ca. 2 ppm for the anti diastereomer. A computational search for low energy geometries revealed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f589606752a9d986238cede144638f3e
https://doi.org/10.1021/acs.joc.5b01516
https://doi.org/10.1021/acs.joc.5b01516
Publikováno v:
Organic Letters. 16:3248-3251
Differentially protected 1,2-diols were synthesized by enantioselective aldehyde α-oxygenation followed by organomagnesium or -lithium addition. Contrary to a previous report, the resultant diols possess an anti configuration. Good selectivity was a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110a19175760a776b30e383edb9f2fed
https://doi.org/10.1021/ol501263y
https://doi.org/10.1021/ol501263y