Quantifying Absolute Neutralization Titers against SARS-CoV-2 by a Standardized Virus Neutralization Assay Allows for Cross-Cohort Comparisons of COVID-19 Sera

Autor: Kasopefoluwa Y. Oguntuyo, Christian S. Stevens, Chuan Tien Hung, Satoshi Ikegame, Joshua A. Acklin, Shreyas S. Kowdle, Jillian C. Carmichael, Hsin-Ping Chiu, Kristopher D. Azarm, Griffin D. Haas, Fatima Amanat, Jéromine Klingler, Ian Baine, Suzanne Arinsburg, Juan C. Bandres, Mohammed N. A. Siddiquey, Robert M. Schilke, Matthew D. Woolard, Hongbo Zhang, Andrew J. Duty, Thomas A. Kraus, Thomas M. Moran, Domenico Tortorella, Jean K. Lim, Andrea V. Gamarnik, Catarina E. Hioe, Susan Zolla-Pazner, Stanimir S. Ivanov, Jeremy P. Kamil, Florian Krammer, Benhur Lee

Publikováno v: mBio, Vol 12, Iss 1 (2021)

Vaccines and antibody-based therapeutics like convalescent-phase plasma therapy are premised upon inducing or transferring neutralizing antibodies that inhibit SARS-CoV-2 entry into cells. Virus neutralization assays (VNAs) for measuring neutralizing

Externí odkaz: https://doaj.org/article/9f425d57749f4d2aabcd8c8d41ea0f24

Tetracistronic minigenomes elucidate a functional promoter for Ghana virus and unveils Cedar virus replicase promiscuity for all henipaviruses.

Autor: Haas GD; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Kowdle S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Schmitz KS; Department of Viroscience, Erasmus MC, Rotterdam, the Netherlands., Azarm KD; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Johnson KN; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA., Klain WR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Freiberg AN; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA., Cox RM; Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA., Plemper RK; Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA., Lee B; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Publikováno v: Journal of virology [J Virol] 2024 Oct 22; Vol. 98 (10), pp. e0080624. Date of Electronic Publication: 2024 Sep 30.

SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses.

Autor: Chiu HP; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Yeo YY; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.; Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA, United States., Lai TY; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Hung CT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Kowdle S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Haas GD; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Jiang S; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.; Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA, United States.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; Department of Pathology, Dana Farber Cancer Institute, Boston, MA, United States.; Broad Institute of Harvard and MIT, Cambridge, MA, United States., Sun W; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Lee B; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 05. Date of Electronic Publication: 2024 Sep 05.

Intranasal SARS-CoV-2 Omicron variant vaccines elicit humoral and cellular mucosal immunity in female mice.

Autor: Slamanig S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands., González-Domínguez I; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chang LA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lemus N; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lai TY; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Martínez JL; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Singh G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dolange V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Abdeljawad A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kowdle S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Noureddine M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Warang P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Singh G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lee B; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Schotsaert M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Palese P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: peter.palese@mssm.edu., Sun W; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: weina.sun@mssm.edu.

Publikováno v: EBioMedicine [EBioMedicine] 2024 Jul; Vol. 105, pp. 105185. Date of Electronic Publication: 2024 Jun 07.

A temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery and gene editing in primary human cells.

Autor: Stevens CS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Carmichael J; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Watkinson R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Kowdle S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Reis RA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Hamane K; UCLA School of Nursing, Los Angeles, California, 90095.; UCLA AIDS Institute, Los Angeles, California, 90095., Jang J; UCLA School of Nursing, Los Angeles, California, 90095.; UCLA AIDS Institute, Los Angeles, California, 90095., Park A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Pernet O; UCLA School of Nursing, Los Angeles, California, 90095.; UCLA AIDS Institute, Los Angeles, California, 90095., Khamaikawin W; UCLA School of Nursing, Los Angeles, California, 90095.; UCLA AIDS Institute, Los Angeles, California, 90095., Hong P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Thibault P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Gowlikar A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029., An DS; UCLA School of Nursing, Los Angeles, California, 90095.; UCLA AIDS Institute, Los Angeles, California, 90095., Lee B; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 05. Date of Electronic Publication: 2024 May 05.