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Akademický článek

Macrophage IL-1β contributes to tumorigenesis through paracrine AIM2 inflammasome activation in the tumor microenvironment

Autor: Zhi Huan Chew, Jianzhou Cui, Karishma Sachaphibulkij, Isabelle Tan, Shreya Kar, Kai Kiat Koh, Kritika Singh, Hong Meng Lim, Soo Chin Lee, Alan Prem Kumar, Stephan Gasser, Lina H. K. Lim

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Intracellular recognition of self and non-self -nucleic acids can result in the initiation of effective pro-inflammatory and anti-tumorigenic responses. We hypothesized that macrophages can be activated by tumor-derived nucleic acids to induce inflam

Externí odkaz: https://doaj.org/article/0e7c66659b314a1588999179baf5069b

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Akademický článek

Rationally targeted anti-VISTA antibody that blockades the C-C’ loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner

Autor: Dipti Thakkar, Lillian Liu, Bhushan Dharmadhikari, Shalini Paliwal, Siyu Guan, Shreya Kar, Nikhil K Tulsian, Joshua J Gruber, Leah DiMascio, Konrad H Paszkiewicz, Piers J Ingram, Jerome D Boyd-Kirkup

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 2 (2022)

Background Despite significant progress in cancer immunotherapy in recent years, resistance to existing immune checkpoint therapies (ICT) is common. V-domain Ig suppressor of T cell activation (VISTA), a predominantly myeloid immune checkpoint regula

Externí odkaz: https://doaj.org/article/cd225b70fb06436fb4a651f62922015a

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Akademický článek

Primary Ewing's sarcoma/Primitive neuroectodermal tumour of the kidney: Report of four cases from a tertiary care centre.

Autor: Shreya Kar, Saloni Naresh Shah, Maya Menon, N. Geetha

Publikováno v: Current Problems in Cancer: Case Reports, Vol 3, Iss , Pp 100043- (2021)

Ewing's sarcoma /Primitive neuroectodermal tumours (ES/PNET) are categorized as small round cell tumours which commonly occur in bone and soft-tissue. Primary renal ES/PNET are uncommon with less than 150 cases reported till date. We received 1575 tu

Externí odkaz: https://doaj.org/article/86e75a1a7bcb40948863342ae4d2e3b2

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Data from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Metastatic breast cancer is still incurable so far; new specifically targeted and more effective therapies for triple-negative breast cancer (TNBC) are required in the clinic. In this study, our clinical data have established that basal and claudin-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19a0c0e006c3abbabd69d14315bda93e
https://doi.org/10.1158/1535-7163.c.6539263.v1

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Supplementary Figure 1 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 1: High ANXA1 and PPARγ expression levels positively correlates with the invasive, high-grade phenotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796a52bb0d216b583547635ad48b7918
https://doi.org/10.1158/1535-7163.22509319

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Supplementary Figure 2 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 2: ANXA1 expressing TNBC cell lines display greater sensitivity to PPARγ ligands compared to ANXA1 depleted cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48392110051076c68f80b12a3c9855ed
https://doi.org/10.1158/1535-7163.22509316

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Supplemental Data from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary methods and supplementary figure legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a6963a538aeeeffe32e7e217be5f31
https://doi.org/10.1158/1535-7163.22509322.v1

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Supplementary Figure 3 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 3: PPARγ induced expression of ANXA1 and cell death is abrogated in TNBC cells with pre-incubation of a PPARγ-specific antagonist or use of a dominant negative derivative of PPARγ.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0f8a276b53f71a91851a1a8a4f6ab9
https://doi.org/10.1158/1535-7163.22509313.v1

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Supplementary Figure 4 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 4: PPARγ ligand-induced changes in expression of RIP1 and NEMO and therefore NFκB activity are receptor dependent.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970d9325507dd54cc45444196a0bdeaf
https://doi.org/10.1158/1535-7163.22509310

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Akademický článek

ANTXR1 deficiency promotes fibroblast senescence: implications for GAPO syndrome as a progeroid disorder

Autor: Matthias Przyklenk, Shreya Karmacharya, Debora Bonasera, Arthur-Lauri Pasanen-Zentz, Stanislav Kmoch, Mats Paulsson, Raimund Wagener, Gianmaria Liccardi, Alvise Schiavinato

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract ANTXR1 is one of two cell surface receptors mediating the uptake of the anthrax toxin into cells. Despite substantial research on its role in anthrax poisoning and a proposed function as a collagen receptor, ANTXR1’s physiological function

Externí odkaz: https://doaj.org/article/22356ec8dc874494a392ca8895a39007

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