Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Shrestha, Priyadarsini"'
Publikováno v:
Cells, Vol 11, Iss 2, p 224 (2022)
The growth and maintenance of nearly every tissue in the body is influenced by systemic hormones during embryonic development through puberty and into adulthood. Of the ~130 different hormones expressed in the human body, steroid hormones and peptide
Externí odkaz:
https://doaj.org/article/759924f4c1044c84873d1f7c1f81de44
Publikováno v:
Cells, Vol 10, Iss 8, p 2076 (2021)
Keratoconus (KC) is a common corneal ectatic disease that affects 1:500–1:2000 people worldwide and is associated with a progressive thinning of the corneal stroma that may lead to severe astigmatism and visual deficits. Riboflavin-mediated collage
Externí odkaz:
https://doaj.org/article/08ec240b7f1b4b188769f91a3c150162
Autor:
Hui Qi, Shrestha Priyadarsini, Sarah E. Nicholas, Akhee Sarker-Nag, Jeremy Allegood, Charles E. Chalfant, Nawajes A. Mandal, Dimitrios Karamichos
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 4, Pp 636-648 (2017)
The pathophysiology of human keratoconus (KC), a bilateral progressive corneal disease leading to protrusion of the cornea, stromal thinning, and scarring, is not well-understood. In this study, we investigated a novel sphingolipid (SPL) signaling pa
Externí odkaz:
https://doaj.org/article/f49e47c6a60f4fdfa022c91ad2ee9d5e
Publikováno v:
Journal of Functional Biomaterials, Vol 6, Iss 2, Pp 422-438 (2015)
Keratoconus (KC) is a progressive disease linked to defects in the structural components of the corneal stroma. The extracellular matrix (ECM) is secreted and assembled by corneal keratocytes and regulated by transforming growth factor-β (TGF-β). W
Externí odkaz:
https://doaj.org/article/e9144a000f1049e09a4af7955d6c9eaa
Publikováno v:
Cells, Vol 8, Iss 10, p 1239 (2019)
Collagen crosslinking provides the mechanical strength required for physiological maintenance of the extracellular matrix in most tissues in the human body, including the cornea. Aging and diabetes mellitus (DM) are processes that are both associated
Externí odkaz:
https://doaj.org/article/120d13a04fcd40a38c18be1f5b3f5c86
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176017 (2017)
Keratoconus (KC) is a progressive corneal ectasia linked to thinning of the central cornea. Hard contact lenses, rigid gas permeable lenses, and scleral lenses are the primary treatment modalities for early to mid- stages of KC to correct refractive
Externí odkaz:
https://doaj.org/article/9f1dee0763534d868d5d192cb22c1834
Autor:
Sarah E Nicholas, Tyler G Rowsey, Shrestha Priyadarsini, Nawajes A Mandal, Dimitrios Karamichos
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182390 (2017)
To delineate the role of Sphingolipids (SPLs) in the human cornea and their cross-talks with transforming growth factor beta (TGF-β) in order to develop novel, non-invasive therapies.Human corneal fibroblasts (HCFs) were harvested from healthy donor
Externí odkaz:
https://doaj.org/article/93dd6d9cb89c452d8e98887939e5a40d
Autor:
Dimitrios Karamichos, Kamran M. Riaz, Amy Whelchel, Shrestha Priyadarsini, Sarah E. Nicholas, Rabab Sharif
Publikováno v:
Surv Ophthalmol
Ocular complications from diabetes mellitus are common. Diabetic keratopathy, the most frequent clinical condition affecting the human cornea, is a potentially sight-threatening condition caused mostly by epithelial disturbances that are of clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34c5ad8a3d6647a74140b02ed5e3947
https://doi.org/10.1016/j.survophthal.2020.02.005
https://doi.org/10.1016/j.survophthal.2020.02.005
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168845 (2016)
To establish an in vitro model that would mirror the in vivo corneal stromal environment in diabetes (DM) patients.Human corneal fibroblasts from Healthy (HCFs), Type 1DM (T1DM) and Type 2DM (T2DM) donors were isolated and cultured for 4 weeks with V
Externí odkaz:
https://doaj.org/article/6b057d7905754a3ca6c7af0e87b4986a
Autor:
Shrestha Priyadarsini, Jesper Hjortdal, Akhee Sarker-Nag, Henrik Sejersen, John M Asara, Dimitrios Karamichos
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113310 (2014)
Keratoconus (KC) is a bilateral degenerative disease of the cornea characterized by corneal bulging, stromal thinning, and scarring. The etiology of the disease is unknown. In this study, we identified a new biomarker for KC that is present in vivo a
Externí odkaz:
https://doaj.org/article/310993a9ea5141da8b921041ca28c718