Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shrenik Mehta"'
Autor:
Elizabeth Sara Hecht, Shrenik Mehta, Aaron T. Wecksler, Ben Aguilar, Nathaniel Swanson, Wilson Phung, Ananya Dubey Kelsoe, W. Henry Benner, Devin Tesar, Robert F. Kelley, Wendy Sandoval, Alavattam Sreedhara
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Detection of host cell protein (HCP) impurities is critical to ensuring that recombinant drug products, including monoclonal antibodies (mAbs), are safe. Mechanistic characterization as to how HCPs persist in drug products is important to refining do
Externí odkaz:
https://doaj.org/article/d0847215cccc4d5da45d73cb8db4ce8f
Autor:
Zephania Kwong Glover, Aaron Wecksler, Baikuntha Aryal, Shrenik Mehta, Melissa Pegues, Wayman Chan, Mari Lehtimaki, Allen Luo, Alavattam Sreedhara, V. Ashutosh Rao
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Biotherapeutics are exposed to common transition metal ions such as Cu(II) and Fe(II) during manufacturing processes and storage. IgG1 biotherapeutics are vulnerable to reactive oxygen species (ROS) generated via metal-catalyzed oxidation reactions.
Externí odkaz:
https://doaj.org/article/dc53b90652ca4eb487b24e5e38890be6
Autor:
Aadithya Kannan, Jamie Giddings, Shrenik Mehta, Tiffany Lin, Anthony Tomlinson, Kyle Ritchie, Ian Shieh, Miguel Saggu, Nidhi Doshi
Publikováno v:
Pharmaceutical Research. 39:563-575
Polysorbates (PS) contain polyoxyethylene (POE) sorbitan/isosorbide fatty acid esters that can partially hydrolyze over time in liquid drug products to generate degradants and a remaining intact PS fraction with a modified ester distribution. The deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6321cd3827aa74bb2b52b436d4bca7a
https://doi.org/10.1007/s11095-022-03217-x
https://doi.org/10.1007/s11095-022-03217-x
Publikováno v:
Pharmaceutical research. 38(8)
To evaluate the physical and chemical degradation of monoclonal antibodies in the presence of ZnA full length IgG1 monoclonal antibody (mAb1) was formulated with various amounts of ZnmAb1 of the IgG1 subclass undergoes aggregation in the presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07b9a81cfa1ac6c61bedb1013854afe4
https://pubmed.ncbi.nlm.nih.gov/34382142
https://pubmed.ncbi.nlm.nih.gov/34382142
Autor:
Shrenik Mehta, Dwayne Lee
Publikováno v:
WCAE
Chip Multi-Threading is the new wave that is sweeping this decade. It is no more a theoretical discussion topic but one where revolutionary products with CMT will permeate every aspect of computing infrastructure. So, how does Academia innovate on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d252583a22e6878239fb55386152330c
https://doi.org/10.1145/1275633.1275647
https://doi.org/10.1145/1275633.1275647
Autor:
Francine Bacchini, Gabe Moretti, Shrenik Mehta, Masayuki Nakamura, Laurent Ducousso, Harry Foster, Janick Bergeron
Publikováno v:
DAC
Few would disagree that verification takes the lion's share of today's project resources. If we examine the available research, we quickly discover that verification is a significant pain point that consumes massive amounts of time and resources acro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::449f2168181b96a97a564a61378434a1
https://doi.org/10.1145/1065579.1065714
https://doi.org/10.1145/1065579.1065714