Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Shreeram C. Nallar"'
Autor:
Artur Javmen, Jun Zou, Shreeram C. Nallar, Henryk Szmacinski, Joseph R. Lakowicz, Andrew T. Gewirtz, Vladimir Y. Toshchakov
Publikováno v:
The Journal of Immunology. 210:1419-1427
TLR5, which is activated by flagellin, plays an important role in initiating immune response to a broad spectrum of motile bacterial pathogens. TLRs induce intracellular signaling via dimerization of their TIR domains followed by adapter recruitment
Publikováno v:
FASEB J
Although the innate immune receptor protein, Receptor for Advanced Glycation End products (RAGE), has been extensively studied, there has been renewed interest in RAGE for its potential role in sepsis, along with a host of other inflammatory diseases
Autor:
Daniel Prantner, Stefanie N. Vogel, David Spiegel, Katharina Richard, Shreeram C. Nallar, Kim D. Collins
Publikováno v:
J Leukoc Biol
The highly reactive compound methylglyoxal (MG) can cause direct damage to cells and tissues by reacting with cellular macromolecules. MG has been identified as a biomarker associated with increased sepsis-induced mortality. Patients undergoing septi
Autor:
Daniel J. Lindner, Edward R. Hofmann, Shreeram C. Nallar, Dhananjaya V. Kalvakolanu, Jonathan D'Cunha, Xiao Weihua, Limei Lin
Publikováno v:
Journal of Cell Science. 134
Using a genome-wide technical knockout, we isolated a newly identified set of GRIM (genes associated with retinoid-interferon-induced mortality) genes; GRIM genes mediate IFN- and retinoic-acid (RA)-induced cell death. Here, we describe the isolation
Autor:
W.Y.C. Lai, Shreeram C. Nallar, Darren J. Perkins, Stefanie N. Vogel, Katharina Richard, Anne Marie Hansen, Beverly H. Koller
Publikováno v:
Nature immunology
The unique cell biology of Toll-like receptor 4 (TLR4) allows it to initiate two signal-transduction cascades: a signal dependent on the adaptors TIRAP (Mal) and MyD88 that begins at the cell surface and regulates proinflammatory cytokines, and a sig
Autor:
Rachel Fanaroff, Alexandra Vlk, Kari Ann Shirey, W.Y.C. Lai, Darren J. Perkins, Chiguang Feng, Shreeram C. Nallar, Stefanie N. Vogel, Vladimir Y. Toshchakov, Andrei E. Medvedev, Kurt H. Piepenbrink, Katharina Richard, Daniel Prantner, Jorge C. G. Blanco, Archana Gopalakrishnan
Publikováno v:
The Journal of Experimental Medicine
We developed mice expressing Tlr4 SNPs homologous to those expressed in humans and associated with infectious and inflammatory diseases. Cellular and molecular analyses of TLR4 signaling in wild-type vs. TLR4-SNP mice revealed novel mechanisms of LPS
Autor:
Yang Song, Robert K. Ernst, Stefanie N. Vogel, W.Y.C. Lai, Darren J. Perkins, Shreeram C. Nallar, Lynn D. Hawkins, Kari Ann Shirey, Erin Harberts, Anup Mahurkar, Katharina Richard, Archana Gopalakrishnan, Alexandra Vlk
Publikováno v:
Vaccine
Toll-like receptors (TLRs), a family of "pattern recognition receptors," bind microbial and host-derived molecules, leading to intracellular signaling and proinflammatory gene expression. TLR4 is unique in that ligand-mediated activation requires the
Autor:
Shreeram C Nallar, Limei Lin, Varsha Srivastava, Padmaja Gade, Edward R Hofmann, Hafiz Ahmed, Sekhar P Reddy, Dhananjaya V Kalvakolanu
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24082 (2011)
We have recently isolated novel IFN-inducible gene, Gene associated with Retinoid-Interferon-induced Mortality-1 (GRIM-1), using a genetic technique. Moderate ectopic expression of GRIM-1 caused growth inhibition and sensitized cells to retinoic acid
Externí odkaz:
https://doaj.org/article/a6bbe6d88a6946c99961188ff56f603f
Autor:
Ying Zhou, Ying Wei, Jing Zhu, Qingyuan Wang, Liang Bao, Yang Ma, Yu Chen, Dingqing Feng, Aijin Zhang, Jie Sun, Shreeram C Nallar, Keng Shen, Dhananjaya V Kalvakolanu, Weihua Xiao, Bin Ling
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22065 (2011)
Our previous studies showed a down-regulation of GRIM-19 in primary human cervical cancers, and restoration of GRIM-19 induced tumor regression. The induction of tumor suppressor protein p53 ubiquitination and degradation by E6 oncoportein of high ri
Externí odkaz:
https://doaj.org/article/5b23af71b5c4411da9360c10caa69264
Publikováno v:
Molecular Carcinogenesis. 56:1687-1702
p16INK4A and p53 are two important tumor suppressor proteins that play essential roles during cell proliferation and aging through regulating the expression of several genes. Here, we report that p16INK4A and p53 co-regulate a plethora of transcripts