Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Shreedhara Gupta"'
Autor:
Andrés Alloatti, Shreedhara Gupta, Melisa Gualdrón-López, Mariana Igoillo-Esteve, Paul A Nguewa, Gladys Deumer, Pierre Wallemacq, Silvia G Altabe, Paul A M Michels, Antonio D Uttaro
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14239 (2010)
BackgroundTrypanosomes can synthesize polyunsaturated fatty acids. Previously, we have shown that they possess stearoyl-CoA desaturase (SCD) and oleate desaturase (OD) to convert stearate (C18) into oleate (C18:1) and linoleate (C18:2), respectively.
Externí odkaz:
https://doaj.org/article/a57c90e94fae4e52835dda6138b4d99d
Autor:
Shreedhara Gupta, M. Cristina Nonato, Antonio J. Costa-Filho, Patricia R. Feliciano, Marcelo Dias-Baruffi, Paul A.M. Michels, Fabio Henrique Dyszy
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Fumarate hydratases (FHs; EC 4.2.1.2) are enzymes that catalyze the reversible hydration of fumarate to S-malate. Parasitic protists that belong to the genus Leishmania and are responsible for a complex of vector-borne diseases named leishmaniases po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c32cc4def16869c86dda0f19c556df
https://doi.org/10.1016/j.ijbiomac.2012.04.025
https://doi.org/10.1016/j.ijbiomac.2012.04.025
Autor:
Paul A.M. Michels, Domantas Motiejunas, Véronique Hannaert, M. Paola Costi, Samuele Calò, Erika Nerini, Shreedhara Gupta, Alberto Venturelli, Stefan Henrich, Sandra Lazzari, Rosaria Luciani, Stefania Ferrari, Rebecca C. Wade, Federica Morandi
Publikováno v:
ResearcherID
Folate analogue inhibitors of Leishmania major pteridine reductase (PTR1) are potential antiparasitic drug candidates for combined therapy with dihydrofolate reductase (DHFR) inhibitors. To identify new molecules with specificity for PTR1, we carried
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30939b1c3bce24ea0e6f8146e0af3aa4
https://doi.org/10.1021/jm1010572
https://doi.org/10.1021/jm1010572
Publikováno v:
Experimental Parasitology. 123:140-145
Reason for post-kala-azar dermal leishmaniasis (PKDL) is yet to be established. Earlier it was observed that morphology and biochemical properties of host peroxisomes were impaired during Leishmania infection. As peroxisome is known to be involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea5979021d9f9fcb4f35f39a0a93b97
https://doi.org/10.1016/j.exppara.2009.06.013
https://doi.org/10.1016/j.exppara.2009.06.013
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1760:989-992
We have examined fura 2-loaded purified peroxisomes under confocal microscope to prove that this mammalian organelle is a store of intracellular calcium pool. Presence of calcium channel and vanadate sensitive Ca2+-ATPase in the purified peroxisomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf19f202a628d3c6741bfb4490c984d
https://doi.org/10.1016/j.bbagen.2006.02.022
https://doi.org/10.1016/j.bbagen.2006.02.022
Publikováno v:
Analytical Biochemistry. 332:404-408
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40959afbb42936eab9e4d637f445a72
https://doi.org/10.1016/j.ab.2004.05.031
https://doi.org/10.1016/j.ab.2004.05.031
Autor:
Andrea Cavalli, Véronique Hannaert, Shreedhara Gupta, Federica Gibellini, Paola Corona, Paul A.M. Michels, Antonio Carta, Stefania Ferrari, Puneet Saxena, Paola M. Costi, Erika Nerini, Giuseppe Paglietti, Davide Guerrieri, Mario Loriga, Rosaria Luciani
The upregulation of pteridine reductase (PTR1) is a major contributor to antifolate drug resistance in Leishmania spp., as it provides a salvage pathway that bypasses dihydrofolate reductase (DHFR) inhibition. The structure-based optimization of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73077160a6047018fb3658aa3297cdbe
http://www.ncbi.nlm.nih.gov/pubmed/22946585
http://www.ncbi.nlm.nih.gov/pubmed/22946585
Publikováno v:
Advances in the Study of Genetic Disorders
The leishmaniasis is a group of diseases caused by protozoan haemoflagelates of the genus Leishmania1,2. These parasites belong to the family of the Trypanosomatidae (order Kinetoplastida) and are closely related to the Trypanosomes3. Despite enormou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b72e191dbcde68d172569b47a22c0f
https://doi.org/10.5772/23985
https://doi.org/10.5772/23985
Autor:
Andrés Alloatti, Paul A.M. Michels, Pierre Wallemacq, Paul Nguewa, Silvia Altabe, Gladys Deumer, Antonio D. Uttaro, Shreedhara Gupta, Melisa Gualdrón-López
Publikováno v:
Biochemical and biophysical research communications. 412(2)
Trypanosoma brucei, the etiologic agent of sleeping sickness, is exposed to important changes in nutrients and temperature during its life cycle. To adapt to these changes, the fluidity of its membranes plays a crucial role. This fluidity, mediated b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdff9ffc4d6d5390d99c7d94cb2144b
https://pubmed.ncbi.nlm.nih.gov/21820408
https://pubmed.ncbi.nlm.nih.gov/21820408
Publikováno v:
Molecular Biology International
In trypanosomatids, glucose-6-phosphate dehydrogenase (G6PDH), the first enzyme of the pentosephosphate pathway, is essential for the defense of the parasite against oxidative stress. Trypanosoma brucei, Trypanosoma cruzi, and Leishmania mexicana G6P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5edf4cda40df1f317e151b9ee1d906f
https://pubmed.ncbi.nlm.nih.gov/22091394
https://pubmed.ncbi.nlm.nih.gov/22091394