Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Shree Ram Singh"'
Autor:
Kentaro Igarashi, Kei Kawaguchi, Ming Zhao, Tasuku Kiyuna, Kentaro Miyake, Masuyo Miyake, Scott D. Nelson, Sarah M. Dry, Yunfeng Li, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Takashi Higuchi, Shree Ram Singh, Hiroyuki Tsuchiya, Robert M. Hoffman
Publikováno v:
Translational Oncology, Vol 13, Iss 2, Pp 393-400 (2020)
Adult pleomorphic rhabdomyosarcoma (RMS) is a rare and malignant mesenchymal tumor. Recently, we developed a patient-derived orthotopic xenograft (PDOX) model of adult pleomorphic RMS. In the present study, we evaluated the efficacy of tumor-targetin
Externí odkaz:
https://doaj.org/article/cddf69c1a2c246edb97111bbb042292c
Autor:
Takashi Higuchi, Norihiko Sugisawa, Kentaro Miyake, Hiromichi Oshiro, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, Michael Bouvet, Shree Ram Singh, Hiroyuki Tsuchiya, Robert M. Hoffman
Publikováno v:
Translational Oncology, Vol 12, Iss 9, Pp 1257-1263 (2019)
Chemotherapy-resistant osteosarcoma is a recalcitrant disease. It is a frequent cause of death to the patients who are usually adolescent or young adults. The goal of the present study was to determine the efficacy of the combination of olaratumab (O
Externí odkaz:
https://doaj.org/article/6487ece1c28149e49aa1642a550c0e78
Autor:
Takashi Higuchi, Hiromichi Oshiro, Zhiying Zhang, Kentaro Miyake, Norihiko Sugisawa, Yuki Katsuya, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, Ming Zhao, Michael Bouvet, Shree Ram Singh, Hiroyuki Tsuchiya, Robert M Hoffman
Publikováno v:
Translational Oncology, Vol 12, Iss 4, Pp 640-645 (2019)
The goal of the present study was to determine the efficacy of osimertinib (AZD9291), a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor for the treatment of aggressive EGFR-mutant non-small cell lung cancer (NSCLC),
Externí odkaz:
https://doaj.org/article/2752c71a9e05436fb25ab8088b3e6cfc
Autor:
Takashi Higuchi, Kei Kawaguchi, Kentaro Miyake, Hiromichi Oshiro, Zhiying Zhang, Sahar Razmjooei, Sintawat Wangsiricharoen, Kentaro Igarashi, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Scott D. Nelson, Sarah M. Dry, Yunfeng Li, Sant P. Chawla, Frederick C. Eilber, Shree Ram Singh, Hiroyuki Tsuchiya, Robert M. Hoffman
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 111, Iss , Pp 835-840 (2019)
Undifferentiated/unclassified soft-tissue sarcomas (USTS) is recalcitrant neoplasms that is usually treated with doxorubicin (DOX)-containing regimens as first-line therapy. Nanoparticle albumin-bound paclitaxel (nab-PTX) is a nanotechnology-based dr
Externí odkaz:
https://doaj.org/article/9349c389daaa466ebd861566e18c2a63
Autor:
Takashi Higuchi, Norihiko Sugisawa, Jun Ho Park, Yu Sun, Guangwei Zhu, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, Michael Bouvet, Shree Ram Singh, Hiroyuki Tsuchiya, Robert M. Hoffman
Publikováno v:
Translational Oncology, Vol 13, Iss 10, Pp 100826- (2020)
Bone is one of the most frequent metastatic sites in non-small cell lung cancer (NSCLC). Osimertinib, with and without bevacizumab (BV), has been investigated on advanced NSCLC patients. However, the efficacy of those drugs on bone metastasis of NSCL
Externí odkaz:
https://doaj.org/article/d5adad807dbf421e8fc396bc61ab1117
Autor:
Guangwei Zhu, Ming Zhao, Qinghong Han, Yuying Tan, Yu Sun, Michael Bouvet, Bryan Clary, Shree Ram Singh, Jianxin Ye, Robert M. Hoffman
Publikováno v:
Translational Oncology, Vol 13, Iss 3, Pp - (2020)
Purpose: The goal of the present study was to determine the efficacy of temozolomide (TEM) and pazopanib (PAZ) combined with FOLFOX (oxaliplatin, leucovorin and 5-fluorouracil) on a colorectal cancer patient-derived orthotopic xenograft (PDOX) mouse
Externí odkaz:
https://doaj.org/article/31fc435467ca4c34ba1461a117d16831
Autor:
Tasuku Kiyuna, Yasunori Tome, Takashi Murakami, Kei Kawaguchi, Kentaro Igarashi, Kentaro Miyake, Masuyo Miyake, Yunfeng Li, Scott D. Nelson, Sarah M. Dry, Arun S. Singh, Tara A. Russell, Irmina Elliott, Shree Ram Singh, Fuminori Kanaya, Fritz C. Eilber, Robert M. Hoffman
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-8 (2018)
Abstract Background Pleomorphic liposarcoma (PLPS) is a rare, heterogeneous and an aggressive variant of liposarcoma. Therefore, individualized therapy is urgently needed. Our recent reports suggest that trabectedin (TRAB) is effective against severa
Externí odkaz:
https://doaj.org/article/526a9ea2f0b74fe1a95ab0b88aaa5969
Autor:
Takashi Higuchi, Norihiko Sugisawa, Kentaro Miyake, Hiromichi Oshiro, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, Zoey Kline, Michael Bouvet, Shree Ram Singh, Hiroyuki Tsuchiya, Robert M. Hoffman
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 118, Iss , Pp - (2019)
Multidrug resistance (MDR) which results in chemoresistance is a major problem in osteosarcoma. P-glycoprotein (P-gp) plays a critical role in MDR by pumping out chemotherapy agents. Peroxisome proliferator activated receptor gamma (PPARγ) is a nucl
Externí odkaz:
https://doaj.org/article/416585b6ecd84ef88c16785e05f004b2
Autor:
Kentaro Miyake, Takashi Higuchi, Hiromichi Oshiro, Zhiying Zhang, Norihiko Sugisawa, Jun Ho Park, Sahar Razmjooei, Yuki Katsuya, Maryam Barangi, Yunfeng Li, Scott D. Nelson, Takashi Murakami, Yuki Homma, Yukihiko Hiroshima, Ryusei Matsuyama, Michael Bouvet, Sant P. Chawla, Shree Ram Singh, Itaru Endo, Robert M. Hoffman
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 117, Iss , Pp - (2019)
Liposarcoma (LS) is a chemotherapy-resistant disease. The aim of the present study was to find precise therapy for a recurrent dedifferentiated liposarcoma (DDLS) in a patient-derived orthotopic xenograft (PDOX) model. The DDLS PDOX models were estab
Externí odkaz:
https://doaj.org/article/71f048f7abf14fbfb7b32e8006cc37ea
Autor:
Ying Liu, Qinglan Ge, Brian Chan, Hanhan Liu, Shree Ram Singh, Jacob Manley, Jae Lee, Ann Marie Weideman, Gerald Hou, Steven X. Hou
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Both intrinsic and external signals regulate stem cell fate. Here, the authors perform a genome-wide RNAi screen to identify regulators of testis germline stem cells (GSC) in Drosophila, finding more than half of the genes were external regulators an
Externí odkaz:
https://doaj.org/article/4bacdc24e3e94f74b5fe7c8b9d8f0369