Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner

Autor: Chella Krishnan, Karthickeyan, Floyd, Raquel R., Sabir, Simon, Jayasekera, Dulshan W., Leon-Mimila, Paola V., Jones, Anthony E., Cortez, Angel A., Shravah, Varun, Péterfy, Miklós, Stiles, Linsey, Canizales-Quinteros, Samuel, Divakaruni, Ajit S., Huertas-Vazquez, Adriana, Lusis, Aldons J.

Publikováno v: In Cellular and Molecular Gastroenterology and Hepatology 2021 11(2):389-406

Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy

Autor: Chella Krishnan, Karthickeyan, El Hachem, Elie-Julien, Keller, Mark P, Patel, Sanjeet G, Carroll, Luke, Vegas, Alexis Diaz, Gerdes Gyuricza, Isabela, Light, Christine, Cao, Yang, Pan, Calvin, Kaczor-Urbanowicz, Karolina Elżbieta, Shravah, Varun, Anum, Diana, Pellegrini, Matteo, Lee, Chi Fung, Seldin, Marcus M, Rosenthal, Nadia A, Churchill, Gary A, Attie, Alan D, Parker, Benjamin, James, David E, Lusis, Aldons J

Mitochondria play an important role in both normal heart function and disease etiology. We report analysis of common genetic variations contributing to mitochondrial and heart functions using an integrative proteomics approach in a panel of inbred mo

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Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy.

Autor: Chella Krishnan K; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, United States., El Hachem EJ; Department of Integrative Biology and Physiology, Field Systems Biology, Sciences Sorbonne Université, Paris, France., Keller MP; Biochemistry Department, University of Wisconsin-Madison, Madison, United States., Patel SG; Department of Surgery/Division of Cardiac Surgery, University of Southern California Keck School of Medicine, Los Angeles, United States., Carroll L; Metabolic Systems Biology Laboratory, Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, Australia., Vegas AD; Metabolic Systems Biology Laboratory, Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, Australia., Gerdes Gyuricza I; Jackson Laboratory, Bar Harbor, United States., Light C; Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, United States., Cao Y; Department of Medicine/Division of Cardiology, University of California, Los Angeles, Los Angeles, United States., Pan C; Department of Medicine/Division of Cardiology, University of California, Los Angeles, Los Angeles, United States., Kaczor-Urbanowicz KE; Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, United States.; UCLA Institute for Quantitative and Computational Biosciences, Los Angeles, United States., Shravah V; Department of Chemistry, University of California, Los Angeles, United States., Anum D; Department of Integrative Biology and Physiology, University of California, Los Angeles, United States., Pellegrini M; UCLA Institute for Quantitative and Computational Biosciences, Los Angeles, United States., Lee CF; Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, United States.; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, United States., Seldin MM; Center for Epigenetics and Metabolism, Irvine, United States.; Department of Biological Chemistry, University of California, Irvine, United States., Rosenthal NA; Jackson Laboratory, Bar Harbor, United States., Churchill GA; Jackson Laboratory, Bar Harbor, United States., Attie AD; Biochemistry Department, University of Wisconsin-Madison, Madison, United States., Parker B; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Australia., James DE; Metabolic Systems Biology Laboratory, Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, Australia., Lusis AJ; Department of Medicine/Division of Cardiology, University of California, Los Angeles, Los Angeles, United States.; Department of Human Genetics, University of California, Los Angeles, United States.; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, United States.

Publikováno v: ELife [Elife] 2023 Jun 05; Vol. 12. Date of Electronic Publication: 2023 Jun 05.