Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Shraddha V. Bhadada"'
Publikováno v:
Therapeutic Advances in Endocrinology and Metabolism, Vol 2 (2011)
Pharmacological and molecular approaches have shown that an atypical β-adrenoceptor (AR), called β 3 -AR, that is distinct from β 1 -ARs and β 2 -ARs, exists in some tissues in heterogeneous populations such as β 3a -ARs and β 3b -ARs. β 3 -AR
Externí odkaz:
https://doaj.org/article/30cb3695484b4a7dba1d02059afcebf9
Autor:
Piyush Trivedi, Chandan Sahi, Chandrabose Karthikeyan, Neelesh Maheshwari, Amit Kumar Verma, N. S. Hari Narayana Moorthy, Shraddha V. Bhadada
Publikováno v:
Letters in Drug Design & Discovery. 18:121-130
Background : The discovery of novel antidiabetics for the treatment of type 2 diabetes mellitus (T2DM) is an important task nowadays because the current treatment approaches have certain limitations. The reported studies showed that the protein tyros
Publikováno v:
European Journal of Neuroscience. 53:2541-2552
Chronic hyperglycemia induces activation of the polyol-sorbitol pathway, which is a major contributor to microvascular complications like stroke. The current study was designed to elucidate the therapeutic role of α-glucose inhibitor in chronic hype
Publikováno v:
Current Gene Therapy. 20:223-235
Background: Postprandial hyperglycemia considered to be a major risk factor for cerebrovascular complications. Objective: The current study was designed to elucidate the beneficial role of voglibose via in-silico in vitro to in-vivo studies in improv
Autor:
Amit Kumar Verma, N. S. Hari Narayana Moorthy, Neelesh Maheshwari, Piyush Trivedi, Chandan Sahi, C. Karthikeyan, Shraddha V. Bhadada
Publikováno v:
Bioorganic chemistry. 92
A series of ten N-(3-(1H-tetrazole-5-yl)phenyl)acetamide derivatives (NM-07 to NM-16) designed from a lead molecule identified previously in our laboratory were synthesized and evaluated for protein tyrosine phosphatase 1B (PTP1B) inhibitory activity
Publikováno v:
Biomedicine & Pharmacotherapy. 83:221-228
Purpose Tephrosia purpurea (T. purpurea) has been reported to prevent cataract formation in senile cataract model as well as proven effective in STZ induced type 1 diabetes. Aldose reductase (AR) is a key enzyme in the intracellular polyol pathway re
Autor:
Shraddha V. Bhadada, Amit Kumar Verma, Neelesh Maheshwari, Piyush Trivedi, Chandan Sahi, N. S. Hari Narayana Moorthy, Chandrabose Karthikeyan
Publikováno v:
Bioorganic chemistry. 80
Described herein is the synthesis and biological evaluation of a series of non-carboxylic inhibitors of Protein Tyrosine Phosphatase 1B designed using bioisosteric replacement strategy. Six N-(3-(1H-tetrazol-5-yl)phenyl)acetamide derivatives designed
Autor:
Shraddha V, Bhadada, Ramesh K, GoyaL
Publikováno v:
Indian journal of experimental biology. 54(7)
Globally, diabetes is a serious health issue affecting one in 11 adults and consumes 12% of global health expenditure. Prevalence of dyslipidemia in diabetes is not uncommon since decades. Further, patients with type II diabetes have 2-4 folds more r
Publikováno v:
Current Eye Research. 41:222-231
Recent investigations have shown that phytochemical antioxidants can scavenge free radicals and prevent various diseases like cataract. The objective of the present study was to assess the efficacy of the Tephrosia purpurea in preventing these change