Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Shrabasti, Roychoudhury"'
Autor:
Susan Kilgas, Aleem Syed, Patrick Toolan-Kerr, Michelle L. Swift, Shrabasti Roychoudhury, Aniruddha Sarkar, Sarah Wilkins, Mikayla Quigley, Anna R. Poetsch, Maria Victoria Botuyan, Gaofeng Cui, Georges Mer, Jernej Ule, Pascal Drané, Dipanjan Chowdhury
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Tudor Interacting Repair Regulator (TIRR) is an RNA-binding protein (RBP) that interacts directly with 53BP1, restricting its access to DNA double-strand breaks (DSBs) and its association with p53. We utilized iCLIP to identify RNAs that dir
Externí odkaz:
https://doaj.org/article/a3262ed44e984be894b2ab228e2c52d3
Autor:
Utsarga Adhikary, Joao A. Paulo, Marina Godes, Shrabasti Roychoudhury, Michelle S. Prew, Yael Ben-Nun, Ellen W. Yu, Amit Budhraja, Joseph T. Opferman, Dipanjan Chowdhury, Steven P. Gygi, Loren D. Walensky
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113176- (2023)
Summary: MCL-1 is a high-priority target due to its dominant role in the pathogenesis and chemoresistance of cancer, yet clinical trials of MCL-1 inhibitors are revealing toxic side effects. MCL-1 biology is complex, extending beyond apoptotic regula
Externí odkaz:
https://doaj.org/article/8e604e1e9c314f39806640bf06f448b9
Autor:
Yuewen Zhang, Lei Wu, Zhao Wang, Jinpeng Wang, Shrabasti Roychoudhury, Bartlomiej Tomasik, Gang Wu, Geng Wang, Xinrui Rao, Rui Zhou
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
DNA replication is a process fundamental in all living organisms in which deregulation, known as replication stress, often leads to genomic instability, a hallmark of cancer. Most malignant tumors sustain persistent proliferation and tolerate replica
Externí odkaz:
https://doaj.org/article/cf1e63961a2b4edbb51e831c2c6c0864
Autor:
Adam Cornish, Shrabasti Roychoudhury, Krishna Sarma, Suravi Pramanik, Kishor Bhakat, Andrew Dudley, Nitish K. Mishra, Chittibabu Guda
Publikováno v:
BMC Genomics, Vol 21, Iss S11, Pp 1-14 (2020)
Abstract Background Single-cell sequencing enables us to better understand genetic diseases, such as cancer or autoimmune disorders, which are often affected by changes in rare cells. Currently, no existing software is aimed at identifying single nuc
Externí odkaz:
https://doaj.org/article/4524e5dbc4c04ac48b4c46a03907c250
Autor:
Neetha Nanoth Vellichirammal, Abrar Albahrani, Jasjit K. Banwait, Nitish K. Mishra, You Li, Shrabasti Roychoudhury, Mathew J. Kling, Sameer Mirza, Kishor K. Bhakat, Vimla Band, Shantaram S. Joshi, Chittibabu Guda
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 19, Iss , Pp 1379-1398 (2020)
Gene fusions that contribute to oncogenicity can be explored for identifying cancer biomarkers and potential drug targets. To investigate the nature and distribution of fusion transcripts in cancer, we examined the transcriptome data of about 9,000 p
Externí odkaz:
https://doaj.org/article/bbf94d1bc73341c7bfe8c0ac41d268bd
Autor:
Kishor K. Bhakat, Geoffrey Talmon, Vimla Band, Jing Wang, Kayvon Dowlatshahi, Sutapa Ray, Bhopal Mohapatra, Pranjal Biswas, Shrabasti Roychoudhury, Jiping Zeng, Heyu Song
Fluorouracil (5-FU) remains a first-line chemotherapeutic agent for colorectal cancer. However, a subset of colorectal cancer patients who have defective mismatch-repair (dMMR) pathway show resistance to 5-FU. Here, we demonstrate that the efficacy o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1843bf67d130859e00938e1ddd3021
https://doi.org/10.1158/1535-7163.c.6542323
https://doi.org/10.1158/1535-7163.c.6542323
Autor:
Kishor K. Bhakat, Geoffrey Talmon, Vimla Band, Jing Wang, Kayvon Dowlatshahi, Sutapa Ray, Bhopal Mohapatra, Pranjal Biswas, Shrabasti Roychoudhury, Jiping Zeng, Heyu Song
Figure S1. IC50 decreased after APE1 knockdown. Figure S2. MMS increased colocalization of APE1 and FACT complex. Figure S3. FACT knockdown did not affect total APE1 level but decreased the occupancy of APE1 to p21 and DTL promoters. Figure S4. CBL01
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd119a27cebb62635e8405ddebb4e70
https://doi.org/10.1158/1535-7163.22519156
https://doi.org/10.1158/1535-7163.22519156
Publikováno v:
Molecular Cell. 82:2538-2540
Zhao et al. (2022) demonstrate that HIV Tat-specific factor 1, an RPA PARylation reader, recruits Topoisomerase IIβ-binding protein 1 to double-strand break sites specifically in the S phase of the cell cycle to promote homologous recombination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6dd60bed270aa52ab7d4e368cb9f63
https://doi.org/10.1016/j.molcel.2022.06.038
https://doi.org/10.1016/j.molcel.2022.06.038
Autor:
Suravi Pramanik, Jiping Zeng, Yingling Chen, Kishor K. Bhakat, Salma S. Elhag, Shaoyan Xi, Anum Akbar, Hannah L. Harris, Heyu Song, Shrabasti Roychoudhury, Sutapa Ray, Don W. Coulter
Publikováno v:
Cancer Lett
Medulloblastoma (MB) is a malignant pediatric brain tumor with a poor prognosis. Post-surgical radiation and cisplatin-based chemotherapy have been a mainstay of treatment, which often leads to substantial neurocognitive impairments and morbidity, hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8af37190b995a1af9c0230665b6284
https://doi.org/10.1016/j.canlet.2021.07.020
https://doi.org/10.1016/j.canlet.2021.07.020
Autor:
Shantaram S. Joshi, Jasjit K. Banwait, Kishor K. Bhakat, Chittibabu Guda, Neetha Nanoth Vellichirammal, Mathew J. Kling, Shrabasti Roychoudhury, Sameer Mirza, Abrar Albahrani, Vimla Band, Nitish K. Mishra, You Li
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 19, Iss, Pp 1379-1398 (2020)
Molecular Therapy: Nucleic Acids, Vol 19, Iss, Pp 1379-1398 (2020)
Gene fusions that contribute to oncogenicity can be explored for identifying cancer biomarkers and potential drug targets. To investigate the nature and distribution of fusion transcripts in cancer, we examined the transcriptome data of about 9,000 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f540ad1cef84e4d97af0212f28b25e42
http://europepmc.org/articles/PMC7044684
http://europepmc.org/articles/PMC7044684