Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Shozo Sakuma"'
Publikováno v:
Toxicology Letters. 185:32-37
Indomethacin (IND) suppresses the T-dependent antibody response (TDAR) in juvenile males when it is administered to pregnant rats during late gestation. In this study, the effect of IND on cytokine production in juvenile rats was examined to investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ff3a0f40fae763c67d8dee85a01928
https://doi.org/10.1016/j.toxlet.2008.11.013
https://doi.org/10.1016/j.toxlet.2008.11.013
Publikováno v:
Toxicology. 243:23-30
The effect of tacrolimus on epididymal biochemical markers was investigated following single daily subcutaneous doses of 1, 2 and 3 mg kg(-1) day(-1) for 2 weeks to male adult rats. The tacrolimus 2 and 3 mg kg(-1) day(-1) groups showed a significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f82cba34f41ab6cd9246aeb78a6385
https://doi.org/10.1016/j.tox.2007.09.017
https://doi.org/10.1016/j.tox.2007.09.017
Autor:
Shozo, Sakuma
Publikováno v:
Folia Pharmacologica Japonica. 130:216-219
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162021f8b216384e0364cef284765713
https://doi.org/10.1254/fpj.130.216
https://doi.org/10.1254/fpj.130.216
Autor:
Susumu Miyata, Fusako Nishigaki, Shozo Sakuma, Toshitaka Ohkubo, Toshikazu Ogawa, Toshio Goto
Publikováno v:
European Journal of Pharmacology. 437:123-128
FK506 (Tacrolimus) and cyclosporin A exert their immunosuppressive effects via a common mechanism, calcineurin inhibition, after binding to intracellular proteins termed immunophilins: FK506-binding protein (FKBP) and cyclophilin. In this study, FK50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc685a83800d1f088f7090b077bfac13
https://doi.org/10.1016/s0014-2999(02)01269-4
https://doi.org/10.1016/s0014-2999(02)01269-4
Autor:
Shozo Sakuma, Toshio Goto, Yasuyuki Higashi, Tatsuya Sasakawa, Natuki Sato, Tadahiro Amaya, Yoshitaka Ohkubo, Takanori Sengoku
Publikováno v:
International Immunopharmacology. 1:1219-1226
Tacrolimus (FK506) ointment showed remarkable efficacy against atopic dermatitis in animal models and clinical trials. The suppressive effect of tacrolimus on the production of the cytokines involved in atopic dermatitis (IL-2, IL-3, IL-4, IL-5, IFN-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0998562a8b8f4dd5659f07f44262ae
https://doi.org/10.1016/s1567-5769(01)00059-5
https://doi.org/10.1016/s1567-5769(01)00059-5
Autor:
Takehiko Kamijo, Yozo Yasui, Tatsuya Kinoshita, Kouichi Takeuchi, Shozo Sakuma, Yozo Nakazawa, Koji Shinozaki, Shuichi Ishida, Kazuo Sakashita, Susumu Ito, Masaaki Shiohara, Yoshifumi Kawano, Atsushi Komiyama, Akira Ishiguro, Hadija Hemed Mwamtemi, Takashi Kato, Kenichi Koike, Yumi Kurokawa, Hiroshi Miyazaki, Kiyoshi Kitano
Publikováno v:
Scopus-Elsevier
We compared a potential to generate mast cells among various sources of CD34+ peripheral blood (PB) cells in the presence of stem cell factor (SCF) with or without thrombopoietin (TPO), using a serum-deprived liquid culture system. From the time cour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2075200b68b2a470cb96a7f7919bcaa
https://doi.org/10.4049/jimmunol.166.7.4672
https://doi.org/10.4049/jimmunol.166.7.4672
Autor:
Toshio Goto, Yasuko Kato, Yoshitaka Ohkubo, Katsue Magari, Fusako Nishigaki, Tatsuya Sasakawa, Shozo Sakuma, Susumu Miyata
Publikováno v:
British Journal of Pharmacology. 130:1655-1663
The aim of this study was to elucidate the in vitro inhibitory potency of FK506 on production of the inflammatory cytokines, tumour necrosis factor (TNF)-α and interleukin (IL)-1β, with a view to assessing this immunosuppressive agent as a potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c635a167eaf6951ed1734451ed1519c
https://doi.org/10.1038/sj.bjp.0703472
https://doi.org/10.1038/sj.bjp.0703472
Publikováno v:
European Journal of Pharmacology. 379:183-189
The effects of FK506 (tacrolimus hydrate) ointment on cutaneous allergic reactions in mice and rats were investigated. FK506 ointment showed significant suppressive effects on delayed allergic reactions in both species, and especially in rats, its in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7424396ae490d66f6ca6fc169ca376
https://doi.org/10.1016/s0014-2999(99)00500-2
https://doi.org/10.1016/s0014-2999(99)00500-2
Autor:
Shozo Sakuma, Masakazu Kobayashi, Toshikazu Ogawa, Yuka Akiyama, Kouichi Tamura, Takashi Fujitsu, Yasutomo Fujii, Hongsi Jiang
Publikováno v:
Transplant International. 12:92-99
Although tacrolimus has been studied in a wide variety of experimental animal models, we are the first group to systematically study the effect of tacrolimus on rat renal allograft survival, as primary therapy and as anti-rejection therapy, in compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c9080479f2542df3d2b90aeb3f442e
https://doi.org/10.1007/s001470050192
https://doi.org/10.1007/s001470050192
Publikováno v:
Doboku Gakkai Ronbunshu. 1992:9-18
著者らは, 応力測定の新しい方法であるダブルフラクチャリング法におけるボーリング孔軸に垂直な2次元面での応力測定理論等について報告した (土木学会論文集, 1989. 6). 本論文は, この
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7e078951ee37264ed15587f4ed77cd2
https://doi.org/10.2208/jscej.1992.448_9
https://doi.org/10.2208/jscej.1992.448_9