Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shozo NAKAMOTO"'
Autor:
Takashi ONO, Katsutoshi YAMADA, Yukiko CHIKAZAWA, Masahiko UENO, Shozo NAKAMOTO, Takayuki OKUNO, Kaoru SENO
Publikováno v:
Biochemical Journal. 363:727-735
Cytosolic phospholipase A2α (cPLA2α), one of the three subtypes of cPLA2 (α, β and γ), is thought to be a rate-limiting enzyme in eicosanoid biosynthesis. We developed a novel and potent cPLA2α inhibitor with an optically active pyrrolidine, te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67d4ec071b2a7070621e26542d645954
https://doi.org/10.1042/bj3630727
https://doi.org/10.1042/bj3630727
Autor:
Yasushi Murakami, Katsutoshi Yamada, Shozo Nakamoto, Takayuki Okuno, Takashi Ono, Koichi Nishi, Kaoru Seno
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:587-590
We synthesized a potent and crystallized human cytosolic phospholipase A 2 α inhibitor, pyrrophenone ( 6 ) which inhibits the isolated enzyme with an IC 50 value of 4.2 nM. Pyrrophenone shows potent inhibition of arachidonic acid release, prostaglan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a243f366da431c00413aa257cfb3ff27
https://doi.org/10.1016/s0960-894x(01)00003-8
https://doi.org/10.1016/s0960-894x(01)00003-8
Autor:
Nobuo Uotani, Yoshimi Kawamura, Shigeru Matsutani, Kazushige Tanaka, Tadashi Yoshida, Tatsuo Tanimoto, Hiroshi Hinoo, Shozo Nakamoto, Koichi Matsumoto, Ryuji Sakazaki
Publikováno v:
The Journal of Antibiotics. 48:106-112
Thielocins A2 alpha, A2 beta, A3, B1, B2 and B3 were isolated as a novel family of phospholipase A2 inhibitors from the fermentation broth of Thielavia terricola RF-143 together with thielavins and thielocins A1 alpha and A1 beta. The most potent inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110647014cde3c1d81118241861d53fa
https://doi.org/10.7164/antibiotics.48.106
https://doi.org/10.7164/antibiotics.48.106
Autor:
Yasushi Murakami, Koichi Nishi, Takashi Ono, Takayuki Okuno, Kaoru Seno, Katsutoshi Yamada, Shozo Nakamoto
Publikováno v:
ChemInform. 32
We synthesized a potent and crystallized human cytosolic phospholipase A 2 α inhibitor, pyrrophenone ( 6 ) which inhibits the isolated enzyme with an IC 50 value of 4.2 nM. Pyrrophenone shows potent inhibition of arachidonic acid release, prostaglan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::197662ce796f3e6589e904ef15735ef6
https://doi.org/10.1002/chin.200126103
https://doi.org/10.1002/chin.200126103
Autor:
Tadashi Yoshida, Ichiro Kudo, Yoshihiro Terui, Tomohiro Sato, Shigeru Matsutani, Ryuzi Sakazaki, Koichi Matsumoto, Hitoshi Arita, Shozo Nakamoto, Keizo Inoue
Publikováno v:
The Journal of Antibiotics. 44:1467-1470
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797839298dd2bc66bf30d9a51c85c4c0
https://doi.org/10.7164/antibiotics.44.1467
https://doi.org/10.7164/antibiotics.44.1467
Autor:
Takashi, Ono, Katsutoshi, Yamada, Yukiko, Chikazawa, Masahiko, Ueno, Shozo, Nakamoto, Takayuki, Okuno, Kaoru, Seno
Publikováno v:
The Biochemical journal. 363(Pt 3)
Cytosolic phospholipase A(2)alpha (cPLA(2)alpha), one of the three subtypes of cPLA(2) (alpha, beta and gamma), is thought to be a rate-limiting enzyme in eicosanoid biosynthesis. We developed a novel and potent cPLA(2)alpha inhibitor with an optical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fc1fa159ace4a7688f8c580daa3a680
https://pubmed.ncbi.nlm.nih.gov/11964173
https://pubmed.ncbi.nlm.nih.gov/11964173
Autor:
Katsutoshi Yamada, Takaharu Matsuura, Sanji Hagishita, Shin-ichiro Hara, Isao Teshirogi, Koichi Nishi, Masahiko Ueno, Takashi Ono, Masaaki Yamada, Kaoru Seno, Tetsuo Okada, Yukiko Chikazawa, Makoto Kii, Takayuki Okuno, Mitsuaki Ohtani, Tomoyuki Ogawa, Yasuhiko Fujii, Fumihiko Watanabe, Shozo Nakamoto, Yasushi Murakami, Hiroshi Hashizume, Masaaki Wada
Publikováno v:
Journal of medicinal chemistry. 43(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7dec5b6dee013e74594fec77f9a2846
https://pubmed.ncbi.nlm.nih.gov/10737736
https://pubmed.ncbi.nlm.nih.gov/10737736