Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Shozo Miyazaki"'
Autor:
Michiya Kobayashi, Shozo Miyazaki, Tetsuya Shimoyama, Antony D'Emanuele, Kunihiko Itoh, David Attwood
Publikováno v:
Drug Development and Industrial Pharmacy. 38:952-960
Elderly patients with swallowing dysfunction may benefit from the oral administration of liquid dosage forms with in situ gelling properties.We have designed in situ gelling liquid dosage formulations composed of mixtures of methylcellulose, which ha
Autor:
Ryozo Mikami, Masatake Dairaku, Akie Takahashi, Kunihiko Itoh, David Attwood, Mariko Ishitani, Shozo Miyazaki, Mitsuo Togashi
Publikováno v:
Drug Development and Industrial Pharmacy. 35:780-787
Oral sustained release gel formulations may provide a means of administering drugs to dysphagic and geriatric patients who have difficulties with handling and taking oral dosage forms.We have designed gel formulations for the oral administration of p
Autor:
Ryozo Mikami, Akie Takahashi, Masatake Dairaku, Kunihiko Itoh, Shozo Miyazaki, Reina Tsuruya, Mitsuo Togashi, Masayuki Yahaba, David Attwood
Publikováno v:
International Journal of Pharmaceutics. 356:95-101
This study has examined the gelation and release characteristics of mixtures of xyloglucan, which has thermally reversible gelation characteristics, and pectin, the gelation of which is ion responsive, with the aim of formulating an in situ gelling v
Autor:
Shozo Miyazaki, Kunihiko Itoh, David Attwood, Mitsuo Togashi, Masatake Dairaku, Ryozo Mikami, Akie Takahashi, Wataru Kubo, Tomohiro Hirayama
Publikováno v:
International Journal of Pharmaceutics. 335:90-96
The aim of the study was to compare the gelation and drug release characteristics of formulations of pectin with high (31%) and low (9%) degrees of methoxylation over a wide pH range (pH 1.2-5.0). Dilute solutions of pectin (1.5%, w/v) containing com
Autor:
David Attwood, Masatake Dairaku, Kunihiko Itoh, Shozo Miyazaki, Ryozo Mikami, Yasuhiro Konno, Mitsuo Togashi, Wataru Kubo, Mariko Fujiwara
Publikováno v:
International Journal of Pharmaceutics. 297:38-49
The aim of this study was to examine the influence of polyhydric alcohols (taste masking agents) on the rheological properties of in situ gelling pectin formulations and on the in vitro and in vivo release of paracetamol and ambroxol from these formu
Publikováno v:
Drug Development and Industrial Pharmacy. 31:819-825
The aim of this study was to evaluate the potential of an in situ gelling pectin formulation as a vehicle for the oral sustained delivery of theophylline and cimetidine. In vitro studies demonstrated diffusion-controlled release of theophylline from
Publikováno v:
International Journal of Pharmaceutics. 271:233-240
Gels formed in situ following oral administration of dilute aqueous solutions of pectin (1.0 and 1.5%, w/v) to rats were evaluated as vehicles for the sustained release of the expectorant drug ambroxol hydrochloride. The solutions contained calcium i
Publikováno v:
Drug Development and Industrial Pharmacy. 30:593-599
The purpose of this study was to evaluate the potential of a pectin formulation with in situ gelling properties for the oral sustained delivery of paracetamol (acetaminophen). The formulations consisted of dilute aqueous solutions (1% to 2% w/v) of l
Publikováno v:
International Journal of Pharmaceutics. 258:55-64
The purpose of this study was to evaluate the potential for the oral sustained delivery of paracetamol of two formulations with in situ gelling properties. Oral administration of aqueous solutions of either gellan gum (1.0%, w/v) or sodium alginate (
Publikováno v:
Drug Development and Industrial Pharmacy. 29:113-119
The purpose of this study was to evaluate the potential of a xyloglucan formulation with in situ gelling properties for the oral sustained delivery of paracetamol. Gelation of dilute aqueous solutions of the polysaccharide xyloglucan occurred in rabb