Výsledky vyhledávání

The Total Synthesis of a Glycosidase Inhibitor, Nagstatin

Autor: Kuniaki Tatsuta, Hiroki Gunji, Shozo Miura

Publikováno v: Bulletin of the Chemical Society of Japan. 70:427-436

A glycosidase inhibitor, nagstatin, has been synthesized from protected L-ribofuranose through the inter- and intra-molecular nucleophilic reactions of the imidazole moieties and the regioselective introduction of a carboxymethyl group.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74d5ed2d3756028bf74972ef11d3f627
https://doi.org/10.1246/bcsj.70.427

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Total synthesis of nagstatin, an N-acetyl-β-D-glucosaminidase inhibitor

Autor: Kuniaki Tatsuta, Shozo Miura

Publikováno v: Tetrahedron Letters. 36:6721-6724

The first enantiospecific total synthesis of nagstatin has been accomplished through the regioselective introduction of an allyl group on the imidazole ring of the de-branched nagstatin precursor followed by conversion into the carboxymethyl group, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75ba2528699477c6e11d6b38982a1c96
https://doi.org/10.1016/00404-0399(50)1361-k

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Total syntheses of de-branched nagstatin and its analogs having glycosidase inhibiting activities

Autor: Shozo Miura, Shigeru Ohta, Hiroki Gunji, Kuniaki Tatsuta

Publikováno v: Tetrahedron Letters. 36:1085-1088

De-branched nagstatin and its analogs have been synthesized from protected L-ribo- and xylofuranoses through the inter- and intra-molecular nucleophilic reactions with the imidazole moieties.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cd1cea191874f3f50b8ce79a1a35d75
https://doi.org/10.1016/0040-4039(94)02460-s

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Practical Preparation of (Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetic Acid: A Side-Chain of the Fourth Generation of Cephem Antibiotics

Autor: Yasuyuki Kurita, Takashi Inagaki, Tetsuro Tamai, Hiroki Gunji, Ryonosuke Yoshida, Kuniaki Tatsuta, Shozo Miura

Publikováno v: Bulletin of the Chemical Society of Japan. 67:1701-1707

A Z-isomer (4) of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid, which is the common acyl moiety of clinically useful cephem antibiotics, has been prepared from the aminoisoxazoles through the skeletal rearrangement in several routes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02d96011cd7f9917f1816323abfb8fd6
https://doi.org/10.1246/bcsj.67.1701

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A practical preparation of (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid

Autor: Tetsuro Tamai, Shozo Miura, Ryonosuke Yoshida, Takashi Inagaki, Kuniaki Tatsuta, Hiroki Gunji

Publikováno v: Tetrahedron Letters. 34:6423-6426

A Z -isomer of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid, which is the common acyl moiety of clinically useful cephalosporins, has been prepared from the aminoisoxazols through the thiadiazol-acetate in two pathways.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22afb7b74c6e8f955e59410fb0ccfbf8
https://doi.org/10.1016/0040-4039(93)85061-z

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ChemInform Abstract: A Synthesis and Structural Confirmation of 3,5-Bis(2-alkylimidazol-4- yl)-1,2,4-trithiolanes

Autor: Shozo Miura, Shigeo Fujita, Kano Naoki, Kuniaki Tatsuta

Publikováno v: ChemInform. 25

The structures of the 4-formylimidazole equivalents which were prepared by heating 2-alkyl-4-dithiocarboxylimidazoles with 47% HBr or conc. H 2 SO 4 have been revised to be 3,5-bis(2-alkylimidazol-4-yl)- 1,2,4-trithiolanes by X-ray crystallographic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31244681e7c5eab76a68de1283e81beb
https://doi.org/10.1002/chin.199425133

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