Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Showchien Hsieh"'
Autor:
Steve Mangum, Phillip A. DeSimone, Michael Doukas, Aimee K. Bence, Andrew G. Stead, Kevin M. Koch, Carolyn J. Bowen, Eric B. Anderson, George A. Davis, Deborah A. Smith, Maqbool A. Halepota, Val R. Adams, Showchien Hsieh, Neil L. Spector
Publikováno v:
Investigational New Drugs. 23:39-49
GW572016 is a dual EGFR-ErbB2 inhibitor that has promise as an anticancer agent. Two phase I studies were conducted to determine the safety, tolerability and pharmacokinetics of single and multiple doses given to healthy subjects. The single dose stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66fbca5d0b34fd0d5f06ba0a9f889db
https://doi.org/10.1023/b:drug.0000047104.45929.ea
https://doi.org/10.1023/b:drug.0000047104.45929.ea
Autor:
Showchien Hsieh, Krzysztof Selinger
Publikováno v:
Journal of Chromatography B. 772:347-356
A liquid chromatographic-mass spectrometric (LC-MS) method with rapid automated sample preparation was developed and validated for determination of glybenclamide in human serum. Glybenclamide and its deuterated labelled internal standard were extract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efdd8142768b947c9c6912c7a784bebd
https://doi.org/10.1016/s1570-0232(02)00133-2
https://doi.org/10.1016/s1570-0232(02)00133-2
Publikováno v:
Biochemistry. 37:1046-1052
Corelease of histamine and 5-hydroxytryptamine from individual mast cells has been measured with fast-scan cyclic voltammetry using a carbon-fiber electrode placed next to a single cell. Release events, induced by exposure of the cells to the calcium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f66c87f9e3ab28b049e67b25cf801ed
https://doi.org/10.1021/bi9714868
https://doi.org/10.1021/bi9714868
Autor:
Connie R. Jimenez, James W. Jorgenson, F. Hillenkamp, Ka Wan Li, J. Stahl-Zeng, K. Dreisewerd, R. C. Van Der Schors, Showchien Hsieh, Wijnand P. M. Geraerts
Publikováno v:
Hsieh, S, Dreisewerd, K, van der Schors, R C, Jimenez, C R, Stahl-Zeng, J, Hillenkamp, F, Jorgenson, J W, Geraerts, W P M & Li, K W 1998, ' Separation and identification of peptides in single neurons by microcolumn liquid chromatography-matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and post-source decay analysis ', Analytical Chemistry, vol. 70, pp. 1847-1852 . https://doi.org/10.1021/ac9708295
Analytical Chemistry, 70, 1847-1852. American Chemical Society
Analytical Chemistry, 70, 1847-1852. American Chemical Society
Microcolumn liquid chromatography (LC) was interfaced with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) for separation and identification of peptides present in single neurons from the brain of the snail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96cd65616811ceb0d42d43d222433f24
https://research.vu.nl/en/publications/584cb8fa-60cc-44bc-b0d8-328c6b8cd8f9
https://research.vu.nl/en/publications/584cb8fa-60cc-44bc-b0d8-328c6b8cd8f9
Autor:
James W. Jorgenson, Showchien Hsieh
Publikováno v:
Analytical Chemistry. 69:3907-3914
A microcolumn liquid chromatography method for determining norepinephrine (NE), epinephrine (E), and phenylethanolamine N-methyltransferase (PNMT) enzyme activity in single bovine adrenal medullary cells is presented. Single cells were isolated and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46e64ae04e5b3d4a06f31a5fec8f7b5
https://doi.org/10.1021/ac970221w
https://doi.org/10.1021/ac970221w
Publikováno v:
Analytical Chemistry. 67:4514-4521
The electrochemical oxidation of histamine has been investigated as an analytical tool. In a physiological buffer, histamine is oxidized at carbon fiber microelectrodes at potentials close to the background in a chemically irreversible process. Cylin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd2a8e34a9ac41dca7a590cae51f0b5
https://doi.org/10.1021/ac00120a014
https://doi.org/10.1021/ac00120a014
Autor:
Showchien Hsieh, H. David Husic
Publikováno v:
Phytochemistry. 32:805-810
The characteristics of the fluorescent complex between carbonic anhydrase from the unicellular green alga, Chlamydomonas reinhardtii, and the fluor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60a3723fb9a7700d7d3134453671e5c1
https://doi.org/10.1016/0031-9422(93)85209-a
https://doi.org/10.1016/0031-9422(93)85209-a
Publikováno v:
Rapid communications in mass spectrometry : RCM. 18(3)
An approach is described with turbulent flow on-line extraction liquid chromatography/electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) for GLP quantitative bioanalysis of a drug candidate. Two systems were built in-house with standard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3c1709f4e6ba609cebc84b9deb1bef
https://pubmed.ncbi.nlm.nih.gov/14755613
https://pubmed.ncbi.nlm.nih.gov/14755613
Autor:
Showchien Hsieh, James W. Jorgenson
Publikováno v:
Analytical chemistry. 68(7)
Fused silica capillary liquid chromatography columns with inner diameters between 12 and 33 microns were slurry packed with 5 microns octadecylsilane-modified silica particles. Column efficiencies and van Deemter coefficients were compared. A linear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cd172a5466426fa0538f1aee0ed46c
https://pubmed.ncbi.nlm.nih.gov/8651494
https://pubmed.ncbi.nlm.nih.gov/8651494
Publikováno v:
Biochimica et biophysica acta. 1078(1)
Extracellular carbonic anhydrase from the unicellular green alga Chlamydomonas reinhardtii is an oligomeric protein containing subunits of 36 and 4 kDa which are joined by disulfide bonds to form higher molecular mass oligomers. In this study, the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4edd32cc05ba906a0d1cfb2cc792473
https://pubmed.ncbi.nlm.nih.gov/1904772
https://pubmed.ncbi.nlm.nih.gov/1904772