Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Show Ling Shyng"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract ATP-sensitive potassium (KATP) channels, composed of four pore-lining Kir6.2 subunits and four regulatory sulfonylurea receptor 1 (SUR1) subunits, control insulin secretion in pancreatic β-cells. KATP channel opening is stimulated by PIP2 a
Externí odkaz:
https://doaj.org/article/51943945f40e4fbd84e1af7be3d9f24b
Publikováno v:
Channels, Vol 18, Iss 1 (2024)
ABSTRACTKATP channels are ligand-gated potassium channels that couple cellular energetics with membrane potential to regulate cell activity. Each channel is an eight subunit complex comprising four central pore-forming Kir6 inward rectifier potassium
Externí odkaz:
https://doaj.org/article/ae5b90c7be9645178e9ac3531c0fa733
Autor:
Assmaa ElSheikh, Show-Ling Shyng
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy/childhood and is a serious condition associated with severe recurrent attacks of hypoglycemia due to dysregulated insulin secretion. Timely diagnosis and
Externí odkaz:
https://doaj.org/article/bcfafffee5fa466bad972e67f318d309
Autor:
Kara E Boodhansingh, Zhongying Yang, Changhong Li, Pan Chen, Katherine Lord, Susan A Becker, Lisa J States, N Scott Adzick, Tricia Bhatti, Show-Ling Shyng, Arupa Ganguly, Charles A Stanley, Diva D De Leon
Publikováno v:
European Journal of Endocrinology. 187:301-313
Objective Congenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in children. In addition to typical focal or diffuse HI, some cases with diazoxide-unresponsive congenital HI have atypical pancreatic histology termed Loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7033f1f22538ed7c7ccb84c7c0be3b42
https://doi.org/10.1530/eje-21-1095
https://doi.org/10.1530/eje-21-1095
Autor:
Gregory M Martin, Min Woo Sung, Zhongying Yang, Laura M Innes, Balamurugan Kandasamy, Larry L David, Craig Yoshioka, Show-Ling Shyng
Publikováno v:
eLife, Vol 8 (2019)
ATP-sensitive potassium (KATP) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic β-cells to maintain glucose homeostasis. Mutations t
Externí odkaz:
https://doaj.org/article/68417f8fa18d401f85e4752b23508b29
Autor:
Camden M. Driggers, Show-Ling Shyng
Publikováno v:
The Journal of general physiology. 155(1)
Gated by intracellular ATP and ADP, ATP-sensitive potassium (KATP) channels couple cell energetics with membrane excitability in many cell types, enabling them to control a wide range of physiological processes based on metabolic demands. The KATP ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a9c560411f2baf7d290ac004306c8d
https://pubmed.ncbi.nlm.nih.gov/36441147
https://pubmed.ncbi.nlm.nih.gov/36441147
Publikováno v:
eLife, Vol 6 (2017)
Sulfonylureas are anti-diabetic medications that act by inhibiting pancreatic KATP channels composed of SUR1 and Kir6.2. The mechanism by which these drugs interact with and inhibit the channel has been extensively investigated, yet it remains unclea
Externí odkaz:
https://doaj.org/article/45ffb1774f404afaa6059c2f3b6c01ff
Autor:
Gregory M Martin, Craig Yoshioka, Emily A Rex, Jonathan F Fay, Qing Xie, Matthew R Whorton, James Z Chen, Show-Ling Shyng
Publikováno v:
eLife, Vol 6 (2017)
KATP channels are metabolic sensors that couple cell energetics to membrane excitability. In pancreatic β-cells, channels formed by SUR1 and Kir6.2 regulate insulin secretion and are the targets of antidiabetic sulfonylureas. Here, we used cryo-EM t
Externí odkaz:
https://doaj.org/article/8633a32722c246dba5825e715bef27dd
Autor:
Veronica Cochrane, Show-Ling Shyng
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2660 (2019)
The adipocyte hormone leptin was first recognized for its actions in the central nervous system to regulate energy homeostasis but has since been shown to have direct actions on peripheral tissues. In pancreatic β-cells leptin suppresses insulin sec
Externí odkaz:
https://doaj.org/article/aa307ae31f554f15a78be2542eabdaef
Publikováno v:
Current Opinion in Structural Biology. 79:102541
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48714c32dd07e0a534b04e90a16f5033
https://doi.org/10.1016/j.sbi.2023.102541
https://doi.org/10.1016/j.sbi.2023.102541