Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shouwu Miao"'
Autor:
Melissa Kirkland, M A Powles, Francisco Velazquez, Eric R. Ashley, Nengxue Wang, Shah Unmesh G, Feroze Ujjainwalla, Taro E. Akiyama, Eric J. Gilbert, Charles Lee Jayne, Michele Pachanski, Dan Zhou, Scott D. Edmondson, Jerry Di Salvo, Andreas Verras, Maria Madeira, Takao Suzuki, Srikanth Venkatraman, Quang Truong, Wu Yin, Gregory L. Adams, Shouwu Miao
Publikováno v:
ACS Medicinal Chemistry Letters. 8:96-101
GPR120 (FFAR4) is a fatty acid sensing G protein coupled receptor (GPCR) that has been identified as a target for possible treatment of type 2 diabetes. A selective activator of GPR120 containing a chromane scaffold has been designed, synthesized, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5c4bd187bc901f79299111d7c132c57
https://doi.org/10.1021/acsmedchemlett.6b00394
https://doi.org/10.1021/acsmedchemlett.6b00394
Autor:
Marzabadi, Mohammad R., Xingfang Hong, Nagarathnam, Dhanapalan, ShouWu Miao, Chiu, George, Wong, Wai C., Wetzel, John M., Fang, James, Forray, Carlos, Chen, Tsing B., O'Malley, Stacey S., Chang, Raymond S.L., Gluchowski, Charles
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1999 9(19):2843-2848
Autor:
Gregory L, Adams, Francisco, Velazquez, Charles, Jayne, Unmesh, Shah, Shouwu, Miao, Eric R, Ashley, Maria, Madeira, Taro E, Akiyama, Jerry, Di Salvo, Takao, Suzuki, Nengxue, Wang, Quang, Truong, Eric, Gilbert, Dan, Zhou, Andreas, Verras, Melissa, Kirkland, Michele, Pachanski, Maryann, Powles, Wu, Yin, Feroze, Ujjainwalla, Srikanth, Venkatraman, Scott D, Edmondson
Publikováno v:
ACS medicinal chemistry letters. 8(1)
GPR120 (FFAR4) is a fatty acid sensing G protein coupled receptor (GPCR) that has been identified as a target for possible treatment of type 2 diabetes. A selective activator of GPR120 containing a chromane scaffold has been designed, synthesized, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b516664a4a45395b9f909635d7176636
https://pubmed.ncbi.nlm.nih.gov/28105282
https://pubmed.ncbi.nlm.nih.gov/28105282
Autor:
Charles Lee Jayne, Francisco Velazquez, Zhuyan Guo, Donald M. Sperbeck, Murali Rajagopalan, Duane Burnette, Karen Marcantonio, Shouwu Miao, Sathesh Bhat, Santhosh Neelamkavil, Linda Brockunier, Stacia Kargman, Yan Xia, Rebecca T. Ruck, Vincent J. Colandrea, John A. Howe, Nicole Buist, Andrew Nolting, Yongxin Han, Pinto Patrick A, Thomas Bara, Mark Cartwright, Robert Chase, Martin C. Clasby, Srikanth Venkatraman, Randy R. Miller, Keith Eagen, Samuel Chackalamannil, Josien Hubert B, Chad Bennett, Mariappan V. Chelliah, Ian W. Davies, Austin Chen, Shah Unmesh G, Sony Agrawal, Dipshikha Biswas, Jin Wu, Aileen Soriano
Publikováno v:
ACS medicinal chemistry letters. 7(1)
We have been focused on identifying a structurally different next generation inhibitor to MK-5172 (our Ns3/4a protease inhibitor currently under regulatory review), which would achieve superior pangenotypic activity with acceptable safety and pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e00f3c3f4a58b31fcc5937b720a0e8
https://pubmed.ncbi.nlm.nih.gov/26819676
https://pubmed.ncbi.nlm.nih.gov/26819676
Autor:
John E. Stelmach, Jianming Bao, Julianne A. Hunt, Ruixiu Wang, James B. Doherty, Cornelis E. C. A. Hop, Stephen J. O'Keefe, Chris M. Thompson, Sanjeev Kumar, Wen Xiao Zhang, Kathleen M. Rupprecht, Rowena D. Ruzek, Wesley L. Shoop, James E. Thompson, Dennis M. Zaller, James V. Pivnichny, Shouwu Miao, Luping Liu, Rose M. Cubbon, Edward A. O'Neill, Peter J. Sinclair
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:64-68
Quinolinones and naphthyridinones with C7 N-t-butyl piperidine substituents were found to be potent p38 MAP kinase inhibitors. These compounds significantly suppress TNF-alpha release in both cellular and LPS-stimulated whole blood assays. They also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3117335dbafb76e1d0cc5a07e0ddfa21
https://doi.org/10.1016/j.bmcl.2005.09.065
https://doi.org/10.1016/j.bmcl.2005.09.065
Autor:
Gloria C. Koo, Laurie A. Castonguay, Mary Jo Staruch, Randal M. Bugianesi, John P. Felix, George A. Doss, Robert S. Slaughter, Marty S. Springer, Andrew Kotliar, Sookhee Ha, Kathleen M. Rupprecht, William H. Parsons, Gregory J. Kaczorowski, Kashmira Shah, Shouwu Miao, Jianming Bao, Maria L. Garcia, Frank Kayser, Robert K. Baker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:447-451
Kv1.3, the voltage-gated potassium channel in human T cells, represents a new target for treating immunosuppression and autoimmune diseases. Correolide (1), a pentacyclic natural product, is a potent and selective Kv1.3 channel blocker. Simplificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b217212f1114b7e5c9d40397d6232c7
https://doi.org/10.1016/j.bmcl.2004.10.058
https://doi.org/10.1016/j.bmcl.2004.10.058
Autor:
Maria L. Garcia, Frank Kayser, Peter J. Sinclair, Mary Jo Staruch, Andrew Kotliar, Nancy N. Tsou, William H. Parsons, Marty S. Springer, Gloria C. Koo, Kathleen M. Rupprecht, William A. Schmalhofer, Gregory J. Kaczorowski, Robert S. Slaughter, Joung L. Goulet, Kashmira Shah, Jianming Bao, Xingfang J. Hong, Frederick Wong, Shouwu Miao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1161-1164
The voltage-gated potassium channel, Kv1.3, is present in human T-lymphocytes. Blockade of Kv1.3 results in T-cell depolarization, inhibition of T-cell activation, and attenuation of immune responses in vivo. A class of benzamide Kv1.3 channel inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd33db6982167b726fc36794cabfa008
https://doi.org/10.1016/s0960-894x(03)00014-3
https://doi.org/10.1016/s0960-894x(03)00014-3
Autor:
Owen B. McManus, Gloria C. Koo, Mary Jo Staruch, Mary Matyskiela, Randal M. Bugianesi, Markus Hanner, John P. Felix, William A. Schmalhofer, Denise Wunderler, B G Green, Robert S. Slaughter, Ana-Rosa Linde-Arias, Cristiano G. Ponte, Gregory J. Kaczorowski, Lucia Velasco, Kathleen M. Rupprecht, William H. Parsons, Shouwu Miao, Maria L. Garcia, Jianming Bao
Publikováno v:
Biochemistry. 41:7781-7794
The voltage-gated potassium channel, K(v)1.3, is a novel target for development of immunosuppressants. Using a functional (86)Rb(+) efflux assay, a new class of high-affinity K(v)1.3 inhibitors has been identified. The initial active in this series,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12018acfcca94b56fc83951d2d375b4
https://doi.org/10.1021/bi025722c
https://doi.org/10.1021/bi025722c
Autor:
Richard Hajdu, Joan M. Pierce, Russell B. Lingham, Carol Ann Keohane, Vincent J. Colandrea, Lisa M. Sonatore, Dietrich Steinhuebel, James A. Milligan, Jeffrey J. Hale, Can D Akyuz, Fred J. Fleitz, Julie A. DeMartino, Suzanne M. Mandala, Michael Wolff, Dhirendra K Jena, John Athanasopoulos, Juncai Meng, Edward C. Sherer, Petr Vachal, Kevin T. Chapman, Jeffrey W. Lusen, Gerard R. Kieczykowski, Scott P. Salowe, Gregory C. Adam, Xinchun Tong, Benjamin D. Stein, Shouwu Miao, Anantha Gollapudi, Lei Xia, Deodial Guiadeen, Matthew J. Wyvratt
Publikováno v:
Journal of medicinal chemistry. 55(7)
The discovery of 1,3,8-triazaspiro[4.5]decane-2,4-diones (spirohydantoins) as a structural class of pan-inhibitors of the prolyl hydroxylase (PHD) family of enzymes for the treatment of anemia is described. The initial hit class, spirooxindoles, was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfa041b8e71a1b6ca8c48a2bfea0fad
https://pubmed.ncbi.nlm.nih.gov/22409479
https://pubmed.ncbi.nlm.nih.gov/22409479
Autor:
Frank Kayser, Jianming Bao, William H. Parsons, Andrew Kotliar, Shouwu Miao, George A. Doss, Robert K. Baker, Kathleen M. Rupprecht
Publikováno v:
Organic Letters. 4:1871-1873
[reaction: see text] Pentacyclic triterpenoid natural product correolide (1) was converted to ketone 2 via ozonolysis. An unusual fragmentation reaction of ketone 2 with LiCl was discovered. This reaction is general among several similar substrates e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607d92d986d46735f3a34cdffdda07ba
https://doi.org/10.1021/ol020053g
https://doi.org/10.1021/ol020053g