Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Shouqing Luo"'
Autor:
Rebecca Z. Fan, Carolina Sportelli, Yanhao Lai, Said S. Salehe, Jennifer R. Pinnell, Harry J. Brown, Jason R. Richardson, Shouqing Luo, Kim Tieu
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)
Abstract Background Dynamin-related protein 1 (Drp1) plays a critical role in mitochondrial dynamics. Partial inhibition of this protein is protective in experimental models of neurological disorders such as Parkinson’s disease and Alzheimer’s di
Externí odkaz:
https://doaj.org/article/be8b808d98e64037a9c09467460b47d3
Autor:
Elizabeth R. Barrow, Evelina Valionyte, Chris R. Baxter, Yi Yang, Sharon Herath, William A. O’Connell, Justyna Lopatecka, Alexander Strachan, Waldemar Woznica, Holly N. Stephenson, Gyorgy Fejer, Vikram Sharma, Boxun Lu, Shouqing Luo
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113935- (2024)
Summary: Autophagy and ribonucleoprotein granules, such as P-bodies (PBs) and stress granules, represent vital stress responses to maintain cellular homeostasis. SQSTM1/p62 phase-separated droplets are known to play critical roles in selective autoph
Externí odkaz:
https://doaj.org/article/4bf4d89b045d48d9a204003eaa8c9070
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract As the population ages, neurodegenerative diseases are becoming more prevalent, making it crucial to comprehend the underlying disease mechanisms and identify biomarkers to allow for early diagnosis and effective screening for clinical trial
Externí odkaz:
https://doaj.org/article/76833d3bf4db4d5cab305ecea4a758f0
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Targeting alpha-synuclein (α-syn) as a therapeutic strategy for Parkinson’s disease (PD) has been intensively pursued largely due to its well-recognized pathogenic role. Since its discovery as the first familial link to PD over two decade
Externí odkaz:
https://doaj.org/article/61773df139804d64b84db2f04e684cb8
Autor:
Yi Yang, Thea L. Willis, Robert W. Button, Conor J. Strang, Yuhua Fu, Xue Wen, Portia R. C. Grayson, Tracey Evans, Rebecca J. Sipthorpe, Sheridan L. Roberts, Bing Hu, Jianke Zhang, Boxun Lu, Shouqing Luo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
The autophagy protein p62 undergoes liquid-liquid phase separation but how this is regulated is unclear. Here, the authors report that the histone chaperone DAXX interacts with p62 in the cytoplasm to drive its phase separation.
Externí odkaz:
https://doaj.org/article/63468e0902e8452ea56c0ff4e2ec70b3
Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8905 (2010)
Huntington's disease (HD) is caused by polyglutamine expansion in huntingtin (htt) protein, but the exact mechanism of HD pathogenesis remains uncertain. Recent evidence suggests that htt proteins with expanded polyglutamine tracts induce endoplasmic
Externí odkaz:
https://doaj.org/article/dd35676a45b9478193cf4018dd1a6ab1
Publikováno v:
Autophagy
SQSTM1/p62, as a major autophagy receptor, forms droplets that are critical for cargo recognition, nucleation, and clearance. p62 droplets also function as liquid assembly platforms to allow the formation of autophagosomes at their surfaces. It is un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61b9362416d1c4555f0316f50453053
https://pubmed.ncbi.nlm.nih.gov/34862482
https://pubmed.ncbi.nlm.nih.gov/34862482
Autor:
Evelina Valionyte, Boxun Lu, Amelia T Bone, Shouqing Luo, Sophie A Griffiths, Elizabeth R Barrow, Vikram Sharma, Yi Yang
Publikováno v:
Cell Death & Differentiation. 29:1211-1227
SQSTM1/p62, as a major autophagy receptor, forms droplets that are critical for cargo recognition, nucleation, and clearance. p62 droplets also function as liquid assembly platforms to allow the formation of autophagosomes at their surfaces. It is un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::269b154237ba13ba29f75c51c82479d1
https://doi.org/10.1038/s41418-021-00912-x
https://doi.org/10.1038/s41418-021-00912-x
Publikováno v:
Cell Res
Cell Research
Cell Research
Degrading pathogenic proteins by degrader technologies such as PROTACs (proteolysis-targeting chimeras) provides promising therapeutic strategies, but selective degradation of non-protein pathogenic biomolecules has been challenging. Here, we demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0e72d2c7388cf505e84854373ccc8a
https://doi.org/10.1038/s41422-021-00532-7
https://doi.org/10.1038/s41422-021-00532-7
Publikováno v:
Acta Pharmacol Sin
The mechanism underlying the resistance of cancer cells to chemotherapeutic drug varies with different cancer cells. Recent evidence shows that lysosomal function is associated with drug resistance of cancer cells. Artesunate, a derivative of artemis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba043b241deb2730b271fe24ac4afb4
https://doi.org/10.1038/s41401-020-0445-z
https://doi.org/10.1038/s41401-020-0445-z