Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Shoulai Gu"'
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e100144 (2014)
Seed storage oil, in the form of triacylglycerol (TAG), is degraded to provide carbon and energy during germination and early seedling growth by the fatty acid β-oxidation in the peroxisome. Although the pathways for lipid degradation have been unco
Externí odkaz:
https://doaj.org/article/74bd6b71f53a48018c722c40e76443e9
Publikováno v:
BMC Plant Biology, Vol 20, Iss 1, Pp 1-14 (2020)
BMC Plant Biology
BMC Plant Biology
Background Triacylglycerols (TAGs) are the main composition of plant seed oil. Long-chain acyl-coenzyme A synthetases (LACSs) catalyze the synthesis of long-chain acyl-coenzyme A, which is one of the primary substrates for TAG synthesis. In Arabidops
Autor:
Saijie Zhu, Douglas D. Fang, Qiang Li, Dongmei Yang, Shoulai Gu, Shaomeng Wang, Dajun Yang, Yifan Zhai
Publikováno v:
Cancer Research. 82:3939-3939
Three core components constitute the polycomb repressive complex 2 (PRC2), a multiprotein complex that catalyzes methylation of histone H3 at lysine 27 (H3K27): (1) enhancer of zeste homolog 2 (EZH2), (2) EED, and (3) suppressor of zeste 12 protein h
Publikováno v:
European Journal of Medicinal Chemistry. 132:157-172
The inhibition of CYP17 to block androgen biosynthesis is a well validated strategy for the treatment of prostate cancer. Herein we reported the design, synthesis and structure–activity relationship (SAR) study for a series of novel 1,2,3,4- tetrah
Autor:
Yunlong Zhou, Shaomeng Wang, Shoulai Gu, Jiao Lingling, Dajun Yang, Guangfeng Wang, Leilei Zhao, Li Dongbo, Chengzhe Wu, Yifan Zhai, Chen Jianyong, Guozhi Tang, Jing Deng, Douglas D. Fang
Publikováno v:
Cancer Research. 80:73-73
Background MCL-1 is an important anti-death BCL-2 family protein and plays a key role in blocking apoptosis in cancer cells. MCL-1 gene is located in one of the most frequently amplified locus in various hematologic malignancies and solid tumors, inc
Publikováno v:
Cancer Research. 80:6216-6216
APG-1387 is a small molecule antagonist of the inhibitor of apoptosis proteins (IAPs) which blocks the activity of IAPs family proteins (XIAP, cIAP-1, cIAP-2, and ML-IAP) and consequently induces apoptosis. It is currently in phase I clinical develop
Autor:
Jingjing Xie, Xiaojia Si, Shoulai Gu, Mingliang Wang, Jian Shen, Haoyan Li, Dan Li, Yanjia Fang, Cong Liu, Jidong Zhu
Publikováno v:
Journal of medicinal chemistry. 60(24)
SHP2, a cytoplasmic protein-tyrosine phosphatase encoded by the PTPN11 gene, is involved in multiple cell signaling processes including Ras/MAPK and Hippo/YAP pathways. SHP2 has been shown to contribute to the progression of a number of cancer types
Publikováno v:
Molecular Plant Pathology. 15:677-689
Summary Sclerotinia sclerotiorum causes a devastating disease in oilseed rape (Brassica napus) resulting in a tremendous yield loss worldwide. Studies on various host–pathogen interactions have shown that plant WRKY transcription factors are essent
Autor:
Guangfeng Wang, Ping Min, Ran Tao, Qixin Wang, Jiaxing Gu, Guoqin Zhai, Dingxiong Chen, Dongmei Yang, Yinfeng Li, Qiuqiong Tang, Shoulai Gu, Yifan Zhai, Jiajun Li, Douglas D. Fang, Dajun Yang
Publikováno v:
Cancer Research. 79:2058-2058
Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are among the most prevalent B-lymphocyte neoplasms with Bruton’s tyrosine kinase (BTK) often found abnormally activated in these patients. BTK inhibitor ibrutinib has showed proven
Autor:
Dingxiong Chen, Ran Tao, Fei Zhang, Rongcheng Xu, Guangfeng Wang, Jiajun Li, Li Rui, Shoulai Gu, Feifei Zhang, Miaoyi Wu, Yifan Zhai, Ping Min, Douglas D. Fang, Dajun Yang, Yingfeng Li, Kejie Lian, Lvcheng Wang, Chunyang Tang, Jingwen Wang
Publikováno v:
Cancer Research. 79:2204-2204
Focal adhesion kinase (FAK) plays an important role in cell migration, growth factor signaling, cell cycle progression and cellular survival. It had been shown that FAK and SRC family kinases were able to sustain downstream AKT and MAPK signaling und