Zobrazeno 1 - 10
of 328
pro vyhledávání: '"Shoukat, Dedhar"'
Autor:
Hassan A. Ali, Joanna M. Karasinska, James T. Topham, Danisha Johal, Steve Kalloger, Andrew Metcalfe, Cassia S. Warren, Anthony Miyagi, Lan V. Tao, Maya Kevorkova, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Seth J. Parker, Daniel J. Renouf, David F. Schaeffer
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-based prognostic PDAC tu
Externí odkaz:
https://doaj.org/article/a2c84c9d9241460d889b4c891a5bea32
Autor:
Paul C. McDonald, Shoukat Dedhar
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The tumour-associated carbonic anhydrases (CA) IX and XII are upregulated by cancer cells to combat cellular and metabolic stress imparted by hypoxia and acidosis in solid tumours. Owing to its tumour-specific expression and function, CAIX is an attr
Externí odkaz:
https://doaj.org/article/1950cb00a5734fb9a07bdd93529ee6ef
Autor:
Alexandre Ghazi, Delphine Le Corre, Camilla Pilati, Julien Taieb, Thomas Aparicio, Audrey Didelot, Shoukat Dedhar, Claire Mulot, Karine Le Malicot, Fatima Djouadi, Aurélien de Reynies, Jean-Marie Launay, Pierre Laurent-Puig, Sophie Mouillet-Richard
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
The CMS4 mesenchymal subtype of colorectal cancer (CRC) is associated with poor prognosis and resistance to treatment. The cellular prion protein PrPC is overexpressed in CMS4 tumors and controls the expression of a panel of CMS4-specific genes in CR
Externí odkaz:
https://doaj.org/article/86b39e402fcf4815994a65717845a5aa
Autor:
Anne E.G. Lenferink, Paul C. McDonald, Christiane Cantin, Suzanne Grothé, Mylene Gosselin, Jason Baardsnes, Myriam Banville, Paul Lachance, Alma Robert, Yuneivy Cepero-Donates, Stevo Radinovic, Patrick Salois, Marie Parat, Hafida Oamari, Annie Dulude, Mehul Patel, Martin Lafrance, Andrea Acel, Nathalie Bousquet-Gagnon, Denis L’Abbé, Alex Pelletier, Félix Malenfant, Maria Jaramillo, Maureen O’Connor-Mccourt, Cunle Wu, Yves Durocher, Mélanie Duchesne, Christine Gadoury, Anne Marcil, Yves Fortin, Beatrice Paul-Roc, Maurizio Acchione, Shawn C. Chafe, Oksana Nemirovsky, Joseph Lau, Francois Bénard, Shoukat Dedhar
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The architectural complexity and heterogeneity of the tumor microenvironment (TME) remains a substantial obstacle in the successful treatment of cancer. Hypoxia, caused by insufficient oxygen supply, and acidosis, resulting from the expulsion of acid
Externí odkaz:
https://doaj.org/article/a78bd5c3c72d4143937f4cd8eec87eef
Autor:
Joey G. Sheff, John F. Kelly, Anna Robotham, Traian Sulea, Félix Malenfant, Denis L’Abbé, Mélanie Duchesne, Alex Pelletier, Jean Lefebvre, Andrea Acel, Marie Parat, Mylene Gosselin, Cunle Wu, Yves Fortin, Jason Baardsnes, Henk Van Faassen, Shannon Awrey, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Anne E.G. Lenferink
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Human carbonic anhydrase (hCAIX), an extracellular enzyme that catalyzes the reversible hydration of CO2, is often overexpressed in solid tumors. This enzyme is instrumental in maintaining the survival of cancer cells in a hypoxic and acidic tumor mi
Externí odkaz:
https://doaj.org/article/05ceb9ddaa0e4ba48f2d8c3227f954cc
Autor:
Geetha Venkateswaran, Shoukat Dedhar
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Solid tumors are challenged with a hypoxic and nutrient-deprived microenvironment. Hence, hypoxic tumor cells coordinatively increase the expression of nutrient transporters and pH regulators to adapt and meet their bioenergetic and biosynthetic dema
Externí odkaz:
https://doaj.org/article/4678fe0b10314a17af7d32888f2d02a4
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3605-3615.e5 (2020)
Summary: Multiple cancer-related genes both promote and paradoxically suppress growth initiation, depending on the cell context. We discover an explanation for how this occurs for one such protein, Stat3, based on asymmetric cell division. Here, we s
Externí odkaz:
https://doaj.org/article/b87d2e772b4446b38ee6cb017486ce29
Autor:
Edward J. Morris, Eiko Kawamura, Jordan A. Gillespie, Aruna Balgi, Nagarajan Kannan, William J. Muller, Michel Roberge, Shoukat Dedhar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Cancer cells have amplified centrosomes and deal with this abnormality by clustering them together so that they can be segregated in daughter cells. Here the authors perform a screening looking for inhibitors of this clustering process and find that
Externí odkaz:
https://doaj.org/article/58af0d7ff4e94bbd92f3feae3e7e8595
Autor:
Jacqueline Tan, Murat Digicaylioglu, Stacy X.J. Wang, Jonathan Dresselhuis, Shoukat Dedhar, Julia Mills
Publikováno v:
Heliyon, Vol 5, Iss 8, Pp e02294- (2019)
Insulin promotes neuronal survival by activating a phosphatidylinositol 3-kinase (PI 3-kinase)/AKT-dependent signaling pathway and reducing caspase activation. We investigated a role for integrin-linked kinase (ILK) in insulin-mediated cell survival
Externí odkaz:
https://doaj.org/article/08af1055d9534e7782679515ad680f53
Autor:
Shoukat Dedhar, Sohrab P. Shah, Youwen Zhou, Andrew I. Minchinton, Ali Bashashati, Jordan A. Gillespie, Jennifer H.E. Baker, Alastair H. Kyle, Alberto Delaidelli, Dongxia Gao, Samantha Burugu, Geetha Venkateswaran, Oksana Nemirovsky, Saeed Saberi, Paul C. McDonald, Shawn C. Chafe
Supplementary Figures S1-S6 and Tables S1-S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62703df9bd4941f7372f5184567b32ca
https://doi.org/10.1158/2326-6066.22542499.v1
https://doi.org/10.1158/2326-6066.22542499.v1
