Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Shoujin Hao"'
Publikováno v:
Hypertension. 80:426-439
Background: Previous studies showed that miR-195a-5p was among the most abundant microRNAs (miRNAs) expressed in the kidney. Methods: Lentivirus silencing of tumor necrosis factor-α (TNF) was performed in vivo and in vitro. Luciferase reporter assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450641929946a017d6872f8138a84554
https://doi.org/10.1161/hypertensionaha.122.19794
https://doi.org/10.1161/hypertensionaha.122.19794
Publikováno v:
Hypertension. 79:2656-2670
TNF-α (tumor necrosis factor-alpha) is the best known as a proinflammatory cytokine; yet, this cytokine also has important immunomodulatory and regulatory functions. As the effects of TNF-α on immune system function were being revealed, the spectru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecaec47741f41afcbe33d7215f9406e
https://doi.org/10.1161/hypertensionaha.122.19464
https://doi.org/10.1161/hypertensionaha.122.19464
Publikováno v:
American Journal of Physiology: Renal Physiology; Jan2024, Vol. 326 Issue 1, pF152-F164, 13p
Publikováno v:
Physiology. 38
We previously showed that production of tumor necrosis factor-alpha (TNF) by the kidney, under normotensive, non-inflammatory conditions, inhibits expression of angiotensinogen in the proximal tubule and NKCC2 isoform A in the thick ascending limb of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d23ded4f1ba073e56407cc661457f490
https://doi.org/10.1152/physiol.2023.38.s1.5731150
https://doi.org/10.1152/physiol.2023.38.s1.5731150
Publikováno v:
Am J Physiol Renal Physiol
Although administration of hypertonic saline (HSS) in combination with diuretics has yielded improved weight loss, preservation of renal function, and reduction in hospitalization time in the clinical setting of patients with acute decompensated hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c6420cfd78e76cef5f57c51a0d14ad
https://doi.org/10.1152/ajprenal.00686.2020
https://doi.org/10.1152/ajprenal.00686.2020
Autor:
Elizabeth D. Drugge, Khalid Farhan, Hong Zhao, Rozalia Abramov, Lesley A. Graham, Nancy Stambler, Shoujin Hao, Nicholas R. Ferreri
Publikováno v:
Journal of Human Hypertension.
Previous work in mouse models shows that urinary TNF-α levels become elevated when dietary salt (NaCl) intake increases. To examine if this relationship exists in humans, we conducted a secondary analysis of the Dietary Approaches to Stop Hypertensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1a892b7fbce2560a8f725d686ccc9e
https://doi.org/10.1038/s41371-022-00748-z
https://doi.org/10.1038/s41371-022-00748-z
Publikováno v:
Hypertension
We showed that intrarenal suppression of TNF (tumor necrosis factor) production under low salt (LS) conditions increases renal cortical AGT (angiotensinogen) mRNA and protein expression. Intrarenal injection of murine recombinant TNF attenuated incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98d0e8f9ef5ae0723335b1b7eb47581
https://doi.org/10.1161/hypertensionaha.120.15435
https://doi.org/10.1161/hypertensionaha.120.15435
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea7a2c3fcf9477dafca0b656d672d47d
https://doi.org/10.1096/fasebj.2022.36.s1.r4186
https://doi.org/10.1096/fasebj.2022.36.s1.r4186
Publikováno v:
Journal of Biological Chemistry. 295:11068-11081
The human cytochrome P450 family 11 subfamily B member 2 (hCYP11B2) gene encodes aldosterone synthase, the rate-limiting enzyme in the biosynthesis of aldosterone. In some humans, hCYP11B2 undergoes a unique intron conversion whose function is largel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8791c7f1d29c2f40c8cdbe697c380493
https://doi.org/10.1074/jbc.ra120.013047
https://doi.org/10.1074/jbc.ra120.013047
Autor:
Nicholas R. Ferreri, Khalid A Farhan, Lesley Graham, Hong Zhou, Shoujin Hao, Elizabeth D Drugge
Publikováno v:
Hypertension. 76
Hypertension (HTN) is a leading global noncommunicable cause of mortality and dietary salt is the most common modifiable risk factor for HTN. Evidence suggests that tumor necrosis factor alpha (TNF-α) modulates mechanisms that may contribute to salt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::436d4ed225bcdc21ce9ad8546b23d2f2
https://doi.org/10.1161/hyp.76.suppl_1.p023
https://doi.org/10.1161/hyp.76.suppl_1.p023